Category: 106092-09-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106092-09-5,(S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

General procedure: To a solution of carboxylic acid (1 mmol) in CH2Cl2 (10 ml) were added Et3N (2 mmol) and TBTU (1.1 mmol) and the mixture was stirred at room temperature for 15 min. Then amine 1 or 3 (1 mmol)and Et3N (2 mmol) were added and the reaction mixture was stirred at room temperature for 2.5 h. The reaction mixture was diluted with CH2Cl2 (15 ml) and washed with saturated aqueous NaHCO3 solution (2×15 ml). Combined water phases were extracted with CH2Cl2 (1 20 ml). Combined organic phases weredried over Na2SO4, filtered and the solvent removed under reduced pressure.

106092-09-5, The synthetic route of 106092-09-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hodnik, ?iga; Toma?i?, Tihomir; Ma?i?, Lucija Peterlin; Chan, Fiona; Kirby, Robert W.; Madge, David J.; Kikelj, Danijel; European Journal of Medicinal Chemistry; vol. 70; (2013); p. 154 – 164;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

106092-09-5, (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Starting compound (S)-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine(29)(4.00g;23.6mmol)was dissolved in tetrahydrofuran(THF) (30mL)and cooled in an icebath to 0C.Then di-tert-butyldicarbonate (5.42 g, 24.8 mmol) dissolved in THF (15 mL) was added dropwise. The reaction mixture was stirred for 60 h at room temperature. The solvent was removed under reduced pressure. Yield: 99.8% (6.35g),palebrownamorphoussolid.[alpha]D25 -56.8(c0.42,MeOH). 1HNMR(400MHz,DMSO-d6)delta1.39(s,9H,3¡ÁCH3),1.52-1.68(m, 1H, 5-CH2), 1.80-1.90 (m, 1H, 5-CH2), 2.30-2.48 (m, 3H, 4-CH2, 7CH2),2.69(dd,J7,7? =14.9Hz,J7,6 =5.3Hz,1H,7-CH2),3.57-3.70 (m,1H,6-CH),6.65(s,2H,NH2),6.95(d,J=7.7Hz,1H,CONH)ppm. 13C NMR (100 MHz, DMSO-d6) delta 24.9, 28.2, 28.9, 46.8, 77.6, 112.4, 144.1, 154.9, 166.1 ppm. MS (ESI + ): m/z = 292.4 ([M + Na]+), 214.2(100%).

106092-09-5, 106092-09-5 (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole 11521153, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Gjorgjieva, Marina; Kikelj, Danijel; Liekens, Sandra; Lillsunde, Katja-Emilia; Naesens, Lieve; Lamut, Andra?; Tammela, Paeivi; Toma?i?, Tihomir; Bioorganic Chemistry; vol. 98; (2020);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106092-09-5,(S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

Weigh 1.5g of 2-methyl-3-oxopentanoic acid, 1.9g of (S) -2,6-diamino-4,5,6,7-tetrahydrobenzothiazole and 2.3g of triethylamine In a 100 mL single-necked flask, 20 mL DMF was added and stirred well followed by 5.2 g HBTU. The reaction system was stirred at room temperature for 3h. The reaction mixture was diluted with 50 mL of water and extracted three times with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate. The resulting residue was purified by column chromatography to give 2.4 g of light yellow solid with a yield of 74.1%

106092-09-5, 106092-09-5 (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole 11521153, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Chengdu Beite Pharmaceutical Co., Ltd.; Liu Guanfeng; Huang Haoxi; Ren Junfeng; Wu Xiancai; Chen Tonghun; Li Yingfu; Su Zhonghai; (9 pag.)CN106749092; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica