With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109113-98-6,6-(Trifluoromethyl)imidazo[2,1-b]thiazole,as a common compound, the synthetic route is as follows.
At 00C POCl3 (17.1 mmol) is added dropwise to a solution of DMF (20.6 mmol) in chloroform (5.0 mL). A solution of 6-trifluoromethyl-imidazo[2,l-b]thiazole (3.17 mmol) in chloroform (15 mL) is added dropwise at 00C and the mixture is stirred for 3h at RT. After heating for 2.5d to reflux the mixture is poured into ice, extracted three times with DCM, dried over MgSO4 and concentrated under reduced pressure. DCM is added, the obtained precipitate is filtered off and the filtrate is concentrated in vacuo to give a crude product which is dissolved in tert.-butanol (19.5 mL). A solution of sodium chlorite (23.0 mmol) and sodium dihydrogen phosphate dihydrate (17.6 mmol) in water (19.5 mL) is added dropwise and the mixture is stirred for 90 min at RT. The solvents are partially removed in vacuo and the obtained precipitate is filtered off to give the desired product as a white solid. LC-MS: tR = 0.73 min; [M+H]+ = 237.2.
109113-98-6, 109113-98-6 6-(Trifluoromethyl)imidazo[2,1-b]thiazole 11084696, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/16560; (2009); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica