Category: 1094070-77-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1094070-77-5,tert-Butyl (2-bromothiazol-5-yl)carbamate,as a common compound, the synthetic route is as follows.

[00299] 1 , 1 -Dimethylethyl (2-bromo- 1 ,3-thiazol-5 -y l)((2S)-2-(((( 1,1- dimethylethyl)oxy)carbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propyl)-carbamate: To a 250 mL round-bottomed flask was added tert-butyl 2-bromothiazol-5-ylcarbamate (0.75 g, 2.69 mmol), DMF (26.9 mL, 2.69 mmol), and cesium carbonate (1.75 g, 5.37 mmol). The mixture was warmed to 500C and 1,1-dimethylethyl 4-((4-(trifluoromethyl)phenyl)methyl)-l,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide (1.13 g, 2.96 mmol, Scheme 1) was added slowly in 10 mL DMF. After 1 hour, the mixture was cooled, diluted with ether (100 mL) and washed with brine (3×50 mL). The organic layer was dried over sodium sulfate, evaporated onto a plug of silica gel and purified by chromatography through a Redi-Sep pre-packed silica gel column (40 g), eluting with a gradient of 20 % to 100 % EtOAc in hexane, to provide the product (1.42 g, 91 % yield) as a white amorphous solid. LCMS (API-ES) m/z (%): 582 (100%, M+H).

1094070-77-5, The synthetic route of 1094070-77-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; AMGEN INC.; WO2009/11880; (2009); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1094070-77-5,tert-Butyl (2-bromothiazol-5-yl)carbamate,as a common compound, the synthetic route is as follows.

Example 42 Preparation of di(tert-butyl) 2-bromo-1,3-thiazol-5-ylimidodicarbonate To a tetrahydrofuran (THF) (200 mL) solution of (2-bromo-thiazol-5-yl)-carbamic acid tert-butyl ester (19.8 g, 70.9 mmol) at 0 C (ice bath) was added NaH (3.12 g, 78 mmol, 60% dispersion in mineral oil) in one portion. Gas evolution was observed. The reaction was stirred for 30 minutes. (Boc)2O (17.0 g, 78 mmol) was added in one portion. The reaction was stirred for 5 minutes. The reaction vessel was pulled from the cooling bath and the reaction allowed to stir for 30 more minutes. Water and ethyl acetate were added to the reaction mixture. The layers were separated and the aqueous layer was extracted ethyl acetate (2 X). The combined organic layers were dried over MgSO4, filtered, and concentrated. Silica gel column chromatography (20 to 50% ethyl acetate/hexanes) afforded the final product as a white solid (25.0 g, 93% yield): mp 87-89 C; 1H NMR (300 MHz, CDCl3) delta 7.24 (s, 1H), 1.48 (s, 18H); ESIMS m/z 379, 381 (M+1)., 1094070-77-5

As the paragraph descriping shows that 1094070-77-5 is playing an increasingly important role.

Reference：
Patent; Dow AgroSciences, LLC; Trullinger, Tony; Hunter, Ricky; Garizi, Negar; Yap, Maurice; Buysse, Ann; Pernich, Dan; Johnson, Timothy; Bryan, Kristy; Deamicis, Carl; Zhang, Yu; Niyaz, Noormohamed; McLeod, CaSandra; Ross, Ronald; Zhu, Yuanming; Johnson, Peter; Eckelbarger, Joseph; Parker, Marshall; EP2604268; (2015); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica