Category: 1123-51-9

1123-51-9, Benzo[d]thiazol-4-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of BSCA (0.5 g, 2mmol) and thionyl chloride(20mL) was stirred at reflux for 2 h. The reaction was monitoredby IR spectroscopy. Formation of the acyl chloride was confirmedfollowing the wavenumber position in infrared spectroscopypeaks: carbonyl group showed up around: 1682 cm-1 and thesimple bond of OH group was detected around 3448 cm-1 in thestarting acid whereas the carbonyl in the acyl chloride arosearound 1750 cm-1. The resulting acyl chloride was isolated byrotatory evaporation of the thionyl chloride under vacuum andthe excess of thionyl chloride was removed with 3 fractions oftoluene (40mL). The resulting acyl chloride was used withoutfurther purification. A solution of the corresponding amine(2mmol) in dry chloroform (15mL) was added to a mixture ofacyl chloride (0.5 g, 2mmol) and triethylamine (0.28mL, 2mmol)in dry chloroform (40mL). The mixture was stirred at roomtemperature for 12-48 h. The product was isolated by filtrationor by rotatory evaporation of the solvent under vacuum andwashed with water (3 50 mL). Final product was purified bywashing, recrystallization, or column chromatography., 1123-51-9

The synthetic route of 1123-51-9 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Ruberte, Ana Carolina; Plano, Daniel; Encio, Ignacio; Aydillo, Carlos; Sharma, Arun K.; Sanmartin, Carmen; European Journal of Medicinal Chemistry; vol. 157; (2018); p. 14 – 27;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1123-51-9,Benzo[d]thiazol-4-amine,as a common compound, the synthetic route is as follows.

General procedure: 6-Bromo-4-chloroquinoline (1.0 equiv.) and 3,4,5-trimethoxyaniline (1.1 equiv.) were suspended in ethanol (10 mL) and refluxed for 18 h. The crude mixture was purified by flash chromatography using EtOAc:hexane followed by 1-5% methanol in EtOAc, solvent was removed under reduced pressure to afford the desired product (1, 8-11, 13-31, and 33-43).

1123-51-9, 1123-51-9 Benzo[d]thiazol-4-amine 298490, athiazole compound, is more and more widely used in various fields.

Reference：
Article; Asquith, Christopher R.M.; Bennett, James M.; Su, Lianyong; Laitinen, Tuomo; Elkins, Jonathan M.; Pickett, Julie E.; Wells, Carrow I.; Li, Zengbiao; Willson, Timothy M.; Zuercher, William J.; Molecules; vol. 24; 22; (2019);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica