Category: 1123-55-3

1123-55-3, Benzo[d]thiazol-7-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1123-55-3, A mixture of 1, 3-BENZOTHIAZOL-7-AMINE (Description 43,30 mg, 0.2 mmol) and [4- (trifluoromethyl) benzyl] isocyanate (Description 3,40 mg, 0.2 mmol) in DCM (2 ml) was stirred at room temperature for 18 h. TLC analysis showed minimal reaction therefore 1,2-dichloroethane (1 ml) was added and the mixture was heated at 80C for 4 h. N, N-DIMETHYLFOM-LAMIDE (0.25 ml) was then added and the mixture was heated at 80C for 18 h. The mixture was then cooled to room temperature and stirred at this temperature for 2 h. The mixture was filtered to give the title compound as a white solid (28 mg, 40%). 1H NMR (d6 DMSO, 400 MHz) 8 9.33 (1H, s), 8.74 (1H, s), 7.82 (1H, d, J7. 9), 7.73 (3H, m), 7.55 (2H, d, J 8. 0), 7.45 (1H, t, J 8. 0), 7.10 (1H, br. t, J 5.9), 4.44 (2H, br. d, J 5. 9). M/Z (ES+) 352 (M+H+).

As the paragraph descriping shows that 1123-55-3 is playing an increasingly important role.

Reference：
Patent; MERCK SHARP & DOHME LIMITED; WO2005/28445; (2005); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1123-55-3, Benzo[d]thiazol-7-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 6-Bromo-4-chloroquinoline (1.0 equiv.) and 3,4,5-trimethoxyaniline (1.1 equiv.) were suspended in ethanol (10 mL) and refluxed for 18 h. The crude mixture was purified by flash chromatography using EtOAc:hexane followed by 1-5% methanol in EtOAc, solvent was removed under reduced pressure to afford the desired product (1, 8-11, 13-31, and 33-43)., 1123-55-3

1123-55-3 Benzo[d]thiazol-7-amine 12479792, athiazole compound, is more and more widely used in various fields.

Reference：
Article; Asquith, Christopher R.M.; Bennett, James M.; Su, Lianyong; Laitinen, Tuomo; Elkins, Jonathan M.; Pickett, Julie E.; Wells, Carrow I.; Li, Zengbiao; Willson, Timothy M.; Zuercher, William J.; Molecules; vol. 24; 22; (2019);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1123-55-3,Benzo[d]thiazol-7-amine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of aniline 1a (0.45 g, 0.005 mol), triethyl orthoformate (30 mL) and 2 mol of diphenyl phosphite (1.91 g, 0.01 mol) was stirred at 130 C for 2.5 h with continuous removal of ethanol formed. The reaction was monitored by TLC on silica gel using petroleum ether and ethyl acetate (1:2 v/v). After cooling, the volatiles were removed in vacuo. The residue was chromatographed on silica gel using CHCl3-MeOH (9:1).

1123-55-3, The synthetic route of 1123-55-3 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Balakrishna; Narayana Reddy, M. Veera; Rao, P. Visweswara; Kumar, M. Anil; Kumar, B. Siva; Nayak; Reddy, C. Suresh; European Journal of Medicinal Chemistry; vol. 46; 5; (2011); p. 1798 – 1802;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica