Zhu, Yu-Shen; Shi, Linlin; Fu, Lianrong; Chen, Xiran; Zhu, Xinju; Hao, Xin-Qi; Song, Mao-Ping published the artcile< Iodine-catalyzed amination of benzothiazoles with KSeCN in water to access primary 2-aminobenzothiazoles>, SDS of cas: 1160791-13-8, the main research area is primary aminobenzothiazole preparation green chem; benzothiazole selenocyanate potassium amination iodine catalyst.
A facile and sustainable approach for the amination of benzothiazoles I (X = H, N; R = H, 4-Cl, 5-OMe, 6-NO2, 7-C(O)OMe; R1 = H) with KSeCN using iodine as the catalyst in water has been disclosed under transition-metal free conditions. The reaction proceeded smoothly to afford various primary 2-amino benzothiazoles I (R1 = NH2) in up to 96% yield. A series of control experiments were performed, suggesting that a ring-opening mechanism was involved via a radical process. This protocol provides efficient synthesis of primary 2-aminobenzothiazole I (R1 = NH2).
Chinese Chemical Letters published new progress about Amination. 1160791-13-8 belongs to class thiazole, and the molecular formula is C6H4BrN3S, SDS of cas: 1160791-13-8.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica