Category: 118452-02-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118452-02-1,2-Aminothiazole-4-carboxamide,as a common compound, the synthetic route is as follows.

4. g (28 mmol) 2-Aminothiazol-4-carboxamide was dissolved in 40 ml glacial acetic acid, to which added 2.8 ml (29.6 mmol) acetic anhydride, followed by reacting under reflux for 2 hr, and naturally cooling down to precipitate a large quantity of solids, which were filtered, washed and dried to obtain 4.7 g 2-acetylaminothiazol-4-carboxamide (yield 92%) with mp>250 C., 118452-02-1

118452-02-1 2-Aminothiazole-4-carboxamide 257149, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Li, Song; Zhao, Guoming; Xia, Guangqiang; Wang, Lili; Zheng, Zhibing; Xie, Yunde; Zhong, Wu; Xiao, Junhai; Li, Xingzhou; Cui, Hao; US2010/87448; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118452-02-1,2-Aminothiazole-4-carboxamide,as a common compound, the synthetic route is as follows.

To a solution of 2-chloro-6-(trifluoromethyl)benzo[d]oxazole (500 mg, 2.26mmol) in DMF (8.0 mL) were added 2-aminothiazole-4-carboxamide (323mg, 2.26mmol) and K2003 (937mg, 6.78mmol) . The resulting mixture was stirred at 100 00 for 3 h. TLC showed the reaction to be complete. The reaction mixture was poured in to ice water (5OmL). The solid precipitated was filtered and washed with water (5OmL) and dried by azeotropic distillation using toluene. Thus obtained solid was triturated with DCM (lOmL) followed by Et20 (lOmL) and dried under vacuum. The solid was further purified by prep HPLC to afford 2-((6-(trifluoromethyl)benzo[d]oxazol-2- yl)amino)thiazole-4-carboxamide as an off white solid. Yield: 30mg (4.0%); MS (ESl+) for CHNOS m/z 328.99 [M+H] LC purity 98.0 % (Ret. Time- 5.55 mm); 1H NMR (400 MHz, DMSO-d6): 13.02 (5, 1H), 7.96 (5, 1H), 7.88 (bs, 1H), 7.78 (5, 1H), 7.58-7.73 (m, 3H).

118452-02-1, The synthetic route of 118452-02-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; DISCUVA LTD.; MEO, Dr Paul; KHAN, Dr. Nawaz; (284 pag.)WO2018/37223; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

118452-02-1, 2-Aminothiazole-4-carboxamide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4. g (28 mmol) 2-Aminothiazol-4-carboxamide was dissolved in 40 ml glacial acetic acid, to which added 2.8 ml (29.6 mmol) acetic anhydride, followed by reacting under reflux for 2 hr, and naturally cooling down to precipitate a large quantity of solids, which were filtered, washed and dried to obtain 4.7 g 2-acetylaminothiazol-4-carboxamide (yield 92%) with mp >250C., 118452-02-1

The synthetic route of 118452-02-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Beijing Molecule Science and Technology Co., Ltd.; EP2039686; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

118452-02-1, 2-Aminothiazole-4-carboxamide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3: Synthesis of 3-[1-(4-Carbamoyl-thiazol-2-yl)-5-(4-methoxy-phenyl)-1H-pyrrol-2-yl]-propionic acid ethyl ester (1C, R1=4-carbamoyl-thiazol-2-yl, R2=4-methoxy-phenyl) (0161) To a solution of 7-(4-methoxy-phenyl)-4,7-dioxo-heptanoic acid ethyl ester (0.5 mmol), see scheme 1, in ethanol (2 mL) were added the amine (1.5 equivalents) and p-toluenesulfonic acid monohydrate (0.5 eq.). The reaction was run using the Biotage Microwave Initiator for 1 to 3 hours at 150 C. The solvent was removed in vacuo to obtain the crude mixture which was purified by prep silica gel plate to obtain the final product (70 mg, 38%).

118452-02-1, As the paragraph descriping shows that 118452-02-1 is playing an increasingly important role.

Reference：
Patent; Nivalis Therapeutics, Inc.; Wasley, Jan; Rosenthal, Gary J.; Sun, Xicheng; Strong, Sarah; Qiu, Jian; US9138427; (2015); B2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118452-02-1,2-Aminothiazole-4-carboxamide,as a common compound, the synthetic route is as follows.

To a solution of 2-(S)-(2-tert-butoxycarbonylamino-2-phenyl-acetylamino)-3-phenyl-propionic acid (239 mg, 0.6 mmol) and 2-amino-thiazole-4-carboxylic acid amide (71.5 mg, 0.5 mmol) in N,N-dimethylformamide (5 mL) was added diisopropylethylamine (174 muL, 9.99 mmol) and O-benzotriazol-1-yl-N,N,N’,N’-tetramethyluronium hexaflurorophosphate (455 mg, 1.2 mmol) and the mixture stirred at ambient temperature overnight. The reaction was quenched with saturated aqueous ammonium chloride solution (10 mL), the mixture poured into water (50 mL) and extracted with ethyl acetate (3×20 mL). The combined organic extracts were washed with water (3×10 mL), brine (20 mL), dried over sodium sulfate and concentrated in vacuo. The residue was purified by chromatography over silica gel eluted with ethyl acetate to give {[1-((S)-4-carbamoyl-thiazol-2-ylcarbamoyl)-2-phenyl-ethylcarbamoyl]-phenyl-methyl}-carbamic acid tert-butyl ester as a glassy solid (31 mg, 12%). LR-MS: Obs. Mass, 524.25. Calcd. Mass, 524.1967 (M+H)., 118452-02-1

As the paragraph descriping shows that 118452-02-1 is playing an increasingly important role.

Reference：
Patent; Goodnow,, Robert Alan; Huby, Nicholas J.S.; Kong, Norman; McDermott, Lee Apostle; Moliterni, John Anthony; Zhang, Zhuming; US2006/63814; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica