Category: 120-78-5

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 120-78-5, Name is 2,2-Dithiobis(benzothiazole), molecular formula is , belongs to thiazoles compound. In a document, author is Takimoto, Tatsuya, Product Details of 120-78-5.

Simple Synthesis of a Heterocyclophane Exhibiting Anti-c-Met Activity by Acting as a Hatch Blocking Access to the Active Site**

A simple approach to the synthesis of heterocyclophane consisting of two 4,4′-bithiazoles has been developed in mild conditions. The heterocyclophane with two short chains was conveniently prepared by Hantzsch thiazoles synthesis using the reaction of 3-tert-butoxycarbonyl-3-azapentanethiocarboxamide with 1,4-dibromobutane-2,3-dione in methanol under reflux for only 15 min. Amino groups at the linkers of this heterocyclophane can be functionalized to give acylated and carbamate derivatives. Their properties as protein kinase inhibitors were investigated, and one of the heterocyclophanes exhibited specific anti-activity for c-mesenchymal epithelial transition factor (IC50=603 nm), among seven types of protein kinases investigated. The computational site identification by ligand competitive saturation method was used to determine why the one heterocyclophane exhibited strong anti-activity for c-mesenchymal epithelial transition factor.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 120-78-5, in my other articles. Product Details of 120-78-5.

Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica

In an article, author is Duan, Ya-bin, once mentioned the application of 120-78-5, Recommanded Product: 120-78-5, Name is 2,2-Dithiobis(benzothiazole), molecular formula is C14H8N2S4, molecular weight is 332.4867, MDL number is MFCD00022874, category is thiazoles. Now introduce a scientific discovery about this category.

Regulation of High-Altitude Hypoxia on the Transcription of CYP450 and UGT1A1 Mediated by PXR and CAR

Little is known about what roles the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) play in drug metabolism in high-altitude hypoxia. Likewise, the potential interaction of nuclear receptors and drug metabolism enzymes during drug metabolism of high-altitude hypoxia is not fully understood. In this work, we investigated the effects of high-altitude hypoxia on transcriptional regulation of cytochrome P450 (CYP450) and UDP-glucuronosyltransferase 1A1 (UGT1A1) genes mediated by PXR and CAR proteins. The protein and mRNA expressions of CYP450, UGT1A1, PXR, and CAR were determined by enzyme-linked immunosorbent assay and qPCR in rats and HepG2 cell lines under hypoxia. Hypoxia potently inhibited the CYP450 isoforms, UGT1A1, PXR, and CAR protein and mRNA expression. To clarify whether PXR and CAR regulate various genes involved in drug metabolism of high-altitude hypoxia, we investigated the expression of CYP1A2, CYP2C9, CYP2E1, CYP3A4, and UGT1A1 using a dual-luciferase reporter assay after treatment with Ketoconazole (KCZ) and Retinoic acid (RA), or silenced PXR and CAR gene expression. In HepG2 cells, hypoxia, KCZ, and RA inhibited CYP450 isoforms and UGT1A1 expression. Activation of PXR and CAR in cells treated with 6-(4-chlorophenyl)-imidazo (2,1-b) thiazole-5-carbaldehyde (CITCO) and rifampicin (Rif) resulted in the enhancement of CYP450 isoforms, UGT1A1, PXR, and CAR. In contrast, this effect was not observed under hypoxia. Taken together, our results suggest that hypoxia inhibits CYP1A2, CYP2C9, CYP2E1, CYP3A4, and UGT1A1 expressionviathe PXR and CAR regulatory pathway.

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Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica

In an article, author is Mondal, Ashaparna, once mentioned the application of 120-78-5, Quality Control of 2,2-Dithiobis(benzothiazole), Name is 2,2-Dithiobis(benzothiazole), molecular formula is C14H8N2S4, molecular weight is 332.4867, MDL number is MFCD00022874, category is thiazoles. Now introduce a scientific discovery about this category.

DNA targeting half sandwich Ru(ii)-p-cymene-N boolean AND N complexes as cancer cell imaging and terminating agents: influence of regioisomers in cytotoxicity

For diagnosing and annihilating cancer in the human body, herein, we have adopted a one pot convenient synthetic protocol to synthesize a library of half sandwich Ru(ii)-p-cymene-N<^>N complexes under continuous sonication and isolated their regioisomers by preparative thin layer chromatography followed by justification of stability using DFT. The present work has resulted in a library of ruthenium arene complexes and their isolated regioisomers following environmentally benign green processes and their screening of anticancer activity in terms of cytotoxicity and selectivity against cancer cell lines where [(eta(6)-p-cymene)RuCl{2-(5,6-dichloro-1H-benzo[d]imidazole-2-yl)quinolone}] (11j) has been elicited to be significantly more potent as well as selective in Caco-2 and HeLa cell lines than the normal HEK-293 cell line compared to cisplatin and it has even shown marked cytotoxicity against the more aggressive HT-29 colorectal cancer cell line being capable of producing oxidative stress or arresting the cell cycle. Moreover, these types of Ru(ii)-arene complexes exhibited excellent binding efficacy with DNA and the compounds [(eta(6)-p-cymene)RuCl{5-chloro-2-(6-(4-chlorophenyl)pyridin-2-yl)benzo[d]thiazole}]PF6 (8l4), [(eta(6)-p-cymene)Ru-2-(6-(benzofuran-2-yl)pyridin-2-yl)-5-chlorobenzo[d]thiazole (8l9) and [(eta(6)-p-cymene)RuCl{2-(6-nitro-1H-benzo[d]imidazol-2-yl)quinolone}]Cl (11f ‘) and might be applied for cancer theranostic treatment due to their good fluorescence properties and remarkable potency.

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Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 120-78-5, Name is 2,2-Dithiobis(benzothiazole), formurla is C14H8N2S4. In a document, author is Diethelm-Varela, Benjamin, introducing its new discovery. Name: 2,2-Dithiobis(benzothiazole).

Stereoisomerization of human constitutive androstane receptor agonist CITCO

CITCO (6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl) oxime) is a widely used agonist of the human constitutive androstane receptor (hCAR), a key hepatic xenobiotic sensor protein with emerging therapeutic indications. To address the insufficient stability of CITCO, which limits its therapeutic potential, the E- and Z-isomers of CITCO were synthesized and characterized by X-ray crystallography, one- and two-dimensional NMR spectroscopy. The two isomers were found to undergo E/Z isomerizations in solution likely via a protonation-rotation mechanism, time- and concentration-dependently. Our molecular modeling studies suggests both stereoisomers can bind to hCAR. (C) 2020 Elsevier Ltd. All rights reserved.

If you are hungry for even more, make sure to check my other article about 120-78-5, Name: 2,2-Dithiobis(benzothiazole).

Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica

Application of 120-78-5, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 120-78-5, Name is 2,2-Dithiobis(benzothiazole), SMILES is C1(SSC2=NC3=CC=CC=C3S2)=NC4=CC=CC=C4S1, belongs to thiazoles compound. In a article, author is Bozkurt, Selahattin, introduce new discover of the category.

Synthesis, application and AIE properties of novel fluorescent tetraoxocalix[2]arene[2]triazine: The detection of a hazardous anion, cyanate

A highly effective, new heterocalixarene fluorescent receptor comprised of 2-(2-aminophenyl)benzothiazole and tetraoxacalix[2]arene[2]triazine was designed and synthesized by one-step reaction. The sensor candidate exhibiting aggregation induced emission (ALE) was tested for its photophysical behaviour towards detection of various anions. The results showed that our receptor undergo ALE in >40% H2O-DMSO along with large pseudo Stokes shift (Delta lambda = 219 nm) and exhibit selective and sensitive detection towards hazardous cyanide’s oxidation product, cyanate (CNO-) ion over other tested anions. The blue-shifted fluorescence emission (lambda(em) = 492 nm) enhancement with large Stokes shift (Delta lambda = 144 nm) was observed with the increase in cyanate concentration. The synthesized turn-on sensor towards cyanate detection could be applied in real sample analyses as an improvement to the method currently carried out by international standards and hereby a different approach has been made for the detection of cyanide through its oxidation form, cyanate. (C) 2020 Elsevier Ltd. All rights reserved.

Application of 120-78-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 120-78-5 is helpful to your research.

Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica

120-78-5, Name is 2,2-Dithiobis(benzothiazole), molecular formula is C14H8N2S4, belongs to thiazoles compound, is a common compound. In a patnet, author is Li, Jian, once mentioned the new application about 120-78-5, COA of Formula: C14H8N2S4.

Transition Metal-Free Synthesis of Substituted Isothiazoles via Three-Component Annulation of Alkynones, Xanthate and NH4I

A protocol was described to access diverse isothiazoles with functionalization potential via transition metal-free three-component annulation of alkynones, potassium ethylxanthate (EtOCS2K) and ammonium iodide (NH4I). A sequential regioselective hydroamination/thiocarbonylation/intramolecular cyclization cascade achieved the efficient formation of consecutive C-N, C-S and N-S bonds in a one-pot process.

If you¡¯re interested in learning more about 120-78-5. The above is the message from the blog manager. COA of Formula: C14H8N2S4.

Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica

Related Products of 120-78-5, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 120-78-5, Name is 2,2-Dithiobis(benzothiazole), SMILES is C1(SSC2=NC3=CC=CC=C3S2)=NC4=CC=CC=C4S1, belongs to thiazoles compound. In a article, author is Patel, Ajaykumar Manibhai, introduce new discover of the category.

Probing the mechanism of gelation and anion sensing capability of a thiazole based amide gelator: A case study

In priori design of Low Molecular weight Gelators (LMWGs) based on the molecular structure is a challenging task and requires the hierarchy knowledge from single molecule packing to a supramolecular assembly in gelator fibers. A simple strategy to select and probe the packing of a molecule from a crystalline state to a semi solid gel state was undertaken in a Thiazole based amide, undecaneamido thiazole (Thz-9). The novel approach to select the promising molecule with gelation property was made using Small Angle Neutron Scattering (SANS) and Small Angle X-ray Scattering (SAXS) analysis of solid samples. Based on the preliminary examination of SANS/SAXS studies Thz-9 molecule was selected and subjected to study the packing of molecule in crystalline to a gel state. The sol-gel transition and variation of the molecular diameter of the supramolecular assembly of Thz-9 molecules in the various states were established using temperature dependent SANS study. Efforts were also directed to establish the relationship between the packing of molecules in single crystal structure to packing in xerogel (dried gel) using Powder X-ray Diffraction (PXRD). A potential application of Thz-9 as a fluoride ion sensor with good selectivity and sensitivity was established.

Related Products of 120-78-5, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 120-78-5 is helpful to your research.

Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 120-78-5, Name is 2,2-Dithiobis(benzothiazole), formurla is C14H8N2S4. In a document, author is Ghotbi, Golaleh, introducing its new discovery. Category: thiazoles.

Design, synthesis, biological evaluation, and docking study of novel dualacting thiazole-pyridiniums inhibiting acetylcholinesterase and beta-amyloid aggregation for Alzheimer’s disease

New compounds containing thiazole and pyridinium moieties were designed and synthesized. The potency of the synthesized compounds as selective inhibitors of acetylcholinesterase (AChE), and beta-amyloid aggregation (A beta) was evaluated. Compounds 7d and 7j showed the best AChE inhibitory activities at the submicromolar concentration range (IC50 values of 0.40 and 0.69 mu M, respectively). Most of the novel compounds showed moderate to low inhibition of butyrylcholinesterase (BChE), which is indicative of their selective inhibitory effects towards AChE. Kinetic studies using the most potent compounds 7d and 7j confirmed a mixed-type of AChE inhibition mechanism in accordance with the docking results, which shows their interactions with both catalytic active (CAS) and peripheral anionic (PAS) sites. The specific binding of 7a, 7j, and 7m to PAS domain of AChE was also confirmed experimentally. In addition, 7d and 7j were able to show beta-amyloid self-aggregation inhibitory effects (20.38 and 42.66% respectively) stronger than donepezil (14.70%) assayed at 10 mu M concentration. Moreover, compounds 7j and 7m were shown to be effective neuroprotective agents in H2O2-induced oxidative stress on PC12 cells almost similar to those observed for donepezil. The ability of 7j to pass blood-brain barrier was demonstrated using the PAMPA method. The results presented in this work provide useful information about designing novel anti-Alzheimer agents.

If you are hungry for even more, make sure to check my other article about 120-78-5, Category: thiazoles.

Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica

In an article, author is Desai, Nisheeth C., once mentioned the application of 120-78-5, Formula: C14H8N2S4, Name is 2,2-Dithiobis(benzothiazole), molecular formula is C14H8N2S4, molecular weight is 332.4867, MDL number is MFCD00022874, category is thiazoles. Now introduce a scientific discovery about this category.

Synthesis, Antimicrobial Capability and Molecular Docking of Heterocyclic Scaffolds Clubbed by 2-Azetidinone, Thiazole and Quinoline Derivatives

A new set of molecules was designed and synthesized by compilation of pharmacologically potential segments thiazole and quinoline bridged by 2-azetidinone as a linker in a single molecular skeleton. Structural analysis of synthesized molecules (5a-p) was executed by IR, H-1 NMR, C-13 NMR, and mass spectroscopy techniques. Aforesaid compounds were analyzed for investigation of their antimicrobial capability against several bacterial and fungal strains. The synthesized compounds 5b, 5f, 5h, 5i, 5k, and 5l were active against bacterial strains while compounds 5j and 5k were active against fungal strains. Synthesized compounds were found to be potential inhibitors against gram-negative bacterial strains Escherichia coli and Pseudomonas aeruginosa, while the same were not effective against gram-positive strains of Staphylococcus aureus and Streptococcus pyogenes. Compounds with electron-releasing substituents were active molecules against all fungal strains used in screening. Also, the influence of substituents on the antimicrobial activity of target molecules (5a-p) was discussed. Molecular docking study against crucial microbial target beta-Ketoacyl-acyl carrier protein (ACP) synthase III (FabH) could provide valuable insights into their plausible mechanism of action.

If you are interested in 120-78-5, you can contact me at any time and look forward to more communication. Formula: C14H8N2S4.

Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica

Related Products of 120-78-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 120-78-5, Name is 2,2-Dithiobis(benzothiazole), SMILES is C1(SSC2=NC3=CC=CC=C3S2)=NC4=CC=CC=C4S1, belongs to thiazoles compound. In a article, author is Kumar, Gajendra, introduce new discover of the category.

Synthesis, anti-inflammatory and analgesic evaluation of thiazole/oxazole substituted benzothiazole derivatives

Non-Steroidal biologically active heterocyclic compounds 4 (2-(4-chlorophenyl) benzo [d] thiazol-3(2H)-yl)-N-((3-substituted-2-hydrobenzo ldlthiazol-2-yemethylene) thiazol-2-amine (3a-3d), 4-(2-(4-chlorophenyl)benzo [d]thiazol-3(2H)-yl)-N-((3-substituted-2-hydrobenzo [d]thiazol-2-yl)methylene)oxazol-2-amine (3a’-3d’), (Z)-N’-(4-(2-(4-chlorophenyebenzoldlthiazol-3(2H)-yethiaol-2-yl)-N-(4-substituted phenylimino)-3-substituted-2-hydrobenzo thiazole-2-carboxamidine (4a-4h) and (Z)-N’-(4-(2-(4-chlomphenyebenzo [d] thiazol-3(2H)-yl) oxazol-2-yl)-N-(4-substituted phenylimino)-3-substituted-2-hydrobenzo thiazole-2-carboxamidine (4a’-4h’) were synthesized starting from 2-chloro-1-(2-(4-chlomphenyebenzoldlthiazol-3(2H)-yl) ethanone (1). The structure configuration of newly synthesized compounds has been determined by elemental analysis and various spectroscopic (IR, (HNMR)-H-1 and GCMS) techniques. These compounds were tested for their anti-inflammation, analgesic, ulcerogenic, acute toxicity and free radical scavenging action and compared with reference drugs in albino rats. Compound 4-(2-(4-chlomphenyebenzoldlthiazol-3(2H)-yl)-N-((3-substituted-2-hydrobenzo [d] thiazol-2-yl)methylene)thiazol-2-amine (3c) was the most active compound than reference drug at a dose of 50 mg/kg p.o.

Related Products of 120-78-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 120-78-5 is helpful to your research.

Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica