Category: 121-66-4

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General Procedure: Dry sodium nitrite (1.04 g, 15 mmol) was slowly added with stirring to cold concentrated sulphuric acid (10 ml) and warmed to 50 C on water bath. The solution was then cooled to 0 C and a mixture of glacial acetic acid/propionic acid (30 ml, 5:1) was added dropwise with stirring so as to maintain the temperature below 15 C. The resulting solution was then cooled below 0 C and to this, 2-amino-5-nitrothiazole (2.17 g, 15 mmol) was added in small portions while stirring. The stirring was further continued at this temperature for 2 h. The resulting diazonium salt solution was slowly added to resorcinol (1.65 g, 15 mmol) dissolved in 50 ml of 10% sodium hydroxide solution with the reaction temperature was maintained below 0 C. The solution was stirred for 2 h and stood for 30 min to allow the precipitate to settle. The precipitate was filtered and washed several times with water until the filtrate was neutral. The product was finally purified by column chromatography over SiO2 with benzene and ethyl acetate (1:1) as an eluate to give 1.75 g (45% yield) of a., 121-66-4

As the paragraph descriping shows that 121-66-4 is playing an increasingly important role.

Reference£º
Article; Kariduraganavar; Tambe; Tasaganva; Kittur; Kulkarni; Inamdar; Journal of Molecular Structure; vol. 987; 1-3; (2011); p. 158 – 165;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Isatin (5 mmol) was dissolved in methanol (40 mL), and corresponding reactants(amine (R-NH2, 5 mmol) and glacial acetic acid (1 mL) in the given order) were added.Reaction mixture was refluxed at 70 C for 6 h under stirring at atmospheric pressure.ubsequently, the mixture was left overnight without stirring at room temperature. Theobtained crystals were filtered off, dried and recrystallized from methanol. On average, theyield was about 70-79 % (details are given in the Supplementary material)., 121-66-4

The synthetic route of 121-66-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; ?ekularac, Gavrilo M.; Nikoli?, Jasmina B.; Petrovi?, Predrag; Bugarski, Branko; Durovi?, Boban; Drmani?, Sa?a ?.; Journal of the Serbian Chemical Society; vol. 79; 11; (2014); p. 1347 – 1354;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 12 3-[(5-nitrothiazol-2-yl)mercapto]-5-phenyl-1,2,4-triazole (SU4390) (Compound 7) The key starting material 2-bromo-5-nitrothiazole was prepared by treating 2-amino-5-nitrothiazole (Aldrich) with sodium nitrite and hydrogen bromide (Fr. Demande 2,015,434, 1970)., 121-66-4

As the paragraph descriping shows that 121-66-4 is playing an increasingly important role.

Reference£º
Patent; Sugen, Inc.; US5883110; (1999); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

121-66-4, 5-Nitro-2-aminothiazole (1 eq)And triethylamine (1.2 eq) were dissolved in CH 2 Cl 2,Chloroacetyl chloride (1.2 eq) was added dropwise at 0 C,After the addition was completed, the reaction was continued for 5h,The reaction was checked by TLC, leaving no residue of the starting material and stopping the reaction.To the reaction mixture were added 100 ml of distilled water, the aqueous phase was extracted three times with CH 2 Cl 2 (3 ¡Á 100 ml), the organic phase was washed twice with saturated NaCl (2 ¡Á 100 ml), dried over anhydrous magnesium sulfate and then concentrated by evaporation to obtain a crude product. The crude product was purified by column chromatography on silica gel (methylene chloride: methanol = 150: 1, v: v) to give pure yellow solid in 82% yield.

As the paragraph descriping shows that 121-66-4 is playing an increasingly important role.

Reference£º
Patent; Shandong University; Hu Wei; Li Xun; Wang Chuandong; Li Xing; Wang Yan; Wu Yibo; Lu Di; Wu Hao; Zhang Yunxi; (8 pag.)CN106588813; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-amino-5-nitro-1,3-thiazole (0.0015 mol) in dichloromethane, was added triethylamine (1.2 equiv). The reaction mixture was stirred at 5 C for 15 min. After that, a solution of ethyl chlorooxoacetate (0.0018 mol, 1.2 equiv) was added droopingly. The reaction mixture was stirred at room temperature for 6 h. After complete conversion as indicated by TLC, the solvent was removed in vacuo, the residue was neutralized with saturated NaHCO3 solution, and the aqueous layer was extracted with ethyl acetate (3 x 15 mL), washed with water (3 * 20 mL), and dried over anhydrous Na2SO4. The solvent was evaporated in vacuo and the precipitated solids were recrystallized from a mixture of acetonitrile/methanol. Yield: 90%, mp: 252-255 C. 1H NMR (400 MHz, DMSO-d6) delta: 8.67 (1H, s, H-4), 4.32 (2H, q, O-CH2) 1.31 (3H, t, CH3) ppm; 13C NMR (100 MHz, DMSO-d6) delta: 161.7 (C-2), 158.4 (CO-OR), 157.7 (RNH-CO), 143.3 (C-5), 142.7 (C-4), 63.4 (O-CH2), 14.1 (CH3) ppm; MS (FAB+) m/z 246 (M+H+). Anal. Calcd for C7H7N3O5S: C, 34.29; H, 2.88; N, 17.14. Found: C, 34.19; H, 2.83; N, 17.09.

121-66-4, The synthetic route of 121-66-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nava-Zuazo, Carlos; Chavez-Silva, Fabiola; Moo-Puc, Rosa; Chan-Bacab, Manuel Jesus; Ortega-Morales, Benjamin Otto; Moreno-Diaz, Hermenegilda; Diaz-Coutino, Daniel; Hernandez-Nunez, Emanuel; Navarrete-Vazquez, Gabriel; Bioorganic and Medicinal Chemistry; vol. 22; 5; (2014); p. 1626 – 1633;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica