With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1235406-28-6,3-Cyano-4-fluoro-N-(thiazol-2-yl)benzenesulfonamide,as a common compound, the synthetic route is as follows.
General procedure: A 0.2M solution in DMSO of the compound of formula (IV) (500 muL, 100 mumol) was added to a 0.2M solution in DMSO of the compound of formula (II) (500 muL, 100 mumol) followed by anhydrous potassium phosphate (64 mg, 300 mumol). The reaction mixture was heated to 80 C. for 16 hours before concentrating in vacuo. The residue was dissolved in DMSO (1 mL) and purified using preparative HPLC as described below to afford the desired compound of formula (I). The compounds of the Examples in the table belowwere prepared from the appropriate sulphonamide and: (a)3-cyano-4-fluorophenol; (b) 3,4-difluorophenol or (c)3-chioro-4-cyanophenol; according to Library Protocol 3.1., 1235406-28-6
1235406-28-6 3-Cyano-4-fluoro-N-(thiazol-2-yl)benzenesulfonamide 58042268, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; PFIZER LIMITED; Owen, Robert McKenzie; Storer, Robert Ian; US2014/315933; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica