The synthetic route of 1247119-36-3 has been constantly updated, and we look forward to future research findings.
1247119-36-3, (S)-Ethyl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate oxalate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 7: Preparation of cobicistat silicon dioxide Thiazole ethyl ester salt (formula 2) (150 g) in water (250 ml) was added to dichloromethane (800 ml), followed by a slow addition of aqueous potassium bicarbonate (220 g of potassium bicarbonate dissolved 1.250 1 of water). The resulting mixture was stirred for about 1 hour and the aqueous and organic layers were separated. The organic layer was washed with water and then concentrated under vacuum until the reaction mass volume reached about 350 ml. The reaction mass was cooled to about 5 C. An aqueous potassium hydroxide solution (about 23 g of KOH dissolved in 25 ml of water) was slowly added to the cooled reaction mass while maintaining a temperature not more than about 10 C. The mixture was then stirred for about 12 hours at the same temperature. Cobicistat intermediate of formula 3 (100 g) and dichloromethane (350 ml), were added to the mixture and the temperature was adjusted to about -20 C. Hydroxybenzotriazole hydrate (about 25 g) was then added to this mixture. A pre-cooled solution (about -20 C of N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (80 g) in dichloromethane (about 800 ml)) was added to the reaction mixture while the reaction mass temperature was maintained at not more than about -20 C. The reaction mixture was then stirred at about the same temperature for 24 hours. The reaction mass temperature was then adjusted to about 5 C and the reaction was quenched with an aqueous citric acid solution. The aqueous and organic layers were separated and the organic layer was washed once with aqueous potassium bicarbonate solution and water. The organic layer was concentrated under reduced pressure to give cobicistat (about 160 g) as a residue. The residue was dissolved in mixture of dichloromethane (160 ml) and n- hexane (160 ml) at room temperature. Silicon dioxide (150 g) was added to the mixture and stirred for 2-3 hours. The solution was concentrated, cooled, and filtered to give a cobicistat silicon dioxide product (300 g)., 1247119-36-3
The synthetic route of 1247119-36-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MYLAN LABORATORIES LTD.; VADALI, Lakshmana Rao; KONDA, Rameshbabu; DANDALA, Ramesh; WO2015/83066; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica