Category: 126623-65-2

Related Products of 126623-65-2, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 126623-65-2, C7H10BrNO3S. A document type is Article, introducing its new discovery.

A number of isothiazolo[4,5-b]carbazole derivatives were prepared via a Diels-Alder approach involving thermally induced indole-2,3-quinodimethane intermediates. Preliminary biological tests revealed a GSK-3beta kinase inhibitor (29) and some free NH group containing compounds (17d, 19c, 29) displayed selective human carbonic anhydrase I inhibitory activities.

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Reference：
Thiazole | C3H5115NS – PubChem,
Thiazole | chemical compound | Britannica

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 126623-65-2, Name is 4-Bromo-2-(tert-butyl)isothiazol-3(2H)-one 1,1-dioxide, name: 4-Bromo-2-(tert-butyl)isothiazol-3(2H)-one 1,1-dioxide.

A series of benzo[d]isothiazole-1,1-dioxides were designed and evaluated as inhibitors of HCV polymerase NS5B. Structure-based design led to the incorporation of a high affinity methyl sulfonamide group. Structure-activity relationship (SAR) studies of this series revealed analogues with submicromolar potencies in the HCV replicon assay and moderate pharmacokinetic properties. SAR studies combined with structure based drug design focused on the sulfonamide region led to a novel and potent cyclic analogue.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.name: 4-Bromo-2-(tert-butyl)isothiazol-3(2H)-one 1,1-dioxide. In my other articles, you can also check out more blogs about 126623-65-2

Reference：
Thiazole | C3H5114NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.126623-65-2, Name is 4-Bromo-2-(tert-butyl)isothiazol-3(2H)-one 1,1-dioxide, molecular formula is C7H10BrNO3S. In a Article，once mentioned of 126623-65-2, COA of Formula: C7H10BrNO3S

The structure-based design and discovery of the isothiazolidinone (IZD) heterocycle as a mimic of phosphotyrosine (pTyr) has led to the identification of novel IZD-containing inhibitors of protein tyrosine phosphatase 1B (PTP1B). The structure-activity relationships (SARs) of peptidic IZD-containing inhibitors of PTP1B are described along with a novel synthesis of the aryl-IZD fragments via a Suzuki coupling. The SAR revealed the saturated IZD heterocycle (42) is the most potent heterocyclic pTyr mimetic compared to the unsaturated IZD (25), the thiadiazolidinone (TDZ) (38), and the regioisomeric unsaturated IZD (31). The X-ray crystal structures of 11c and 25 complexed with PTP1B were solved and revealed nearly identical binding interactions in the active site. Ab initio calculations effectively explain the strong binding of the (S)-IZD due to the preorganized binding of the IZD in its low energy conformation.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 126623-65-2 is helpful to your research., COA of Formula: C7H10BrNO3S

Reference：
Thiazole | C3H5113NS – PubChem,
Thiazole | chemical compound | Britannica