Category: 131106-70-2

131106-70-2, 6-(Trifluoromethyl)benzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0.05 mole of 6-trifluoromethylbenzothiazole was added to 20 ml of ethyl ether at a temperature ranging -65 to -55 C. On the other hand, 0.05 mole of n-butyl lithium was added to 155 ml of ethyl ether. The former mixture was added to the latter one in a dropwise fashion for 15 minutes. In addition, 0.05 mole of triphenyl bromosilane was added to 20 ml of ethyl ether. This solution was added to the above mixed solution in a dropwise fashion at -45 C. for 5 minutes. It was heated up to -13 C. for 4 hours and maintained at a temperature of -13 to -10 C. for 4 hours. Then, an aqueous ammonium chloride solution and ice were added to the resulting solution to separate an ethyl ether layer. The separated ethyl ether layer was washed with water, dried with sodium sulfate, and treated under reduced pressure to remove a solution. Then, a semi-solid phase material was extracted with 300 ml of boiling petroleum and treated under reduced pressure to remove the solution. When the solution was removed, the extract was washed with 50 ml of ethanol and 15 ml of benzene and then, recrystaled with a mixture of 6 ml of benzene and 15 ml of ethanol to thereby produce a yellow solid at a yield of 23%.

131106-70-2, The synthetic route of 131106-70-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SAMSUNG ELECTRONICS CO., LTD.,; Industry-University Cooperation Foundation, Hanyang University; US2008/207905; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

131106-70-2, 6-(Trifluoromethyl)benzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

21n was dissolved under N2 in EtOH (72 mL). 85% hydrazinehydrate (13.2 g, 223.25 mmol) was added and the mixture wasrefluxed for 3 h. It was then cooled to 0 C and H2O (60 mL) wasadded. 50% acetic acid aqueous solution was added to pH 6e7 andthe mixturewas extracted with DCM. The organic layerwaswashedwith saturated aqueous NaCl and dried over Na2SO4. Then it wasconcentrated to get 5.6 g (Yield 98.2%) of 2-amino-5-(trifluoromethyl)benzenethiol (21m) as a yellow oil without furtherpurification. ES-LCMS m/z: 194.0 (MH).

131106-70-2, As the paragraph descriping shows that 131106-70-2 is playing an increasingly important role.

Reference：
Article; Cao, Hengyi; Zhu, Guangya; Sun, Lin; Chen, Ge; Ma, Xinxin; Luo, Xiao; Zhu, Jidong; European Journal of Medicinal Chemistry; vol. 183; (2019);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.131106-70-2,6-(Trifluoromethyl)benzo[d]thiazole,as a common compound, the synthetic route is as follows.

[00181] A solution of 6-(trifluoromethyl)benzo[d]thiazole (3) (830 mg, 4.08 mmol) and hydrazine monohydrate (1.52 g, 30.6 mmol) in ethanol (20 mL) was heated to reflux for 1.5 h. The mixture was added to a solution of acetic acid (3 mL) in water (100 mL) and extracted with DCM. The organic extract was dried over Na2S04and concentrated under reduced pressure. The crude material was purified by silica gel chromatography to afford 670 mg (84%) of the title compound as a yellow oil. NMR (400 MHz, CDCI3) delta 7.62 (d, J= 1.2 Hz, 1H), 7.39 (dd, J = 8.4, 2.0 Hz, 1H), 6.75 (d, J= 8.4 Hz, 1H), 4.49 (s, 2H), 2.95 (s, 1H).

131106-70-2, The synthetic route of 131106-70-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; NOGRA PHARMA LIMITED; VITI, Francesca; BELLINVIA, Salvatore; DEMARTIS, Salvatore; (104 pag.)WO2015/197861; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.131106-70-2,6-(Trifluoromethyl)benzo[d]thiazole,as a common compound, the synthetic route is as follows.

General procedure: In a two-necked flask equipped with a reflux condenser were placed RhH(PPh3)4 (4 mol%, 11.5 mg), 1,2-bis(diphenylphosphino)ethane (8 mol%, 8.0 mg), 1,3-benzothiazole 5 (0.25 mmol, 27.3 mL), and (alpha-phenylthio)isobutyrophenone 6 (0.25 mmol, 64.0 mg) in chlorobenzene (0.25 mL) under an argon atmosphere, and the solution was heated at reflux for 3 h. The mixture was purified by flash column chromatography on silica gel giving 7 (55.8 mg, 92%) and isobutyrophenone 8 (34.3 mg, 93%) with the recovery of 5 (3.5 mg, 10%) and 6 (0.8 mg, 1%).

131106-70-2, 131106-70-2 6-(Trifluoromethyl)benzo[d]thiazole 14810650, athiazole compound, is more and more widely used in various fields.

Reference：
Article; Arisawa, Mieko; Toriyama, Fumihiko; Yamaguchi, Masahiko; Tetrahedron Letters; vol. 52; 18; (2011); p. 2344 – 2347;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

131106-70-2, 6-(Trifluoromethyl)benzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,131106-70-2

General procedure: To an oven-dried 10 mL vial were added the heteroarene 1 (0.40 mmol, 1.0 equiv), 1-adamantanecarboxylic acid (2; 216 mg, 1.20 mmol, 3.0 equiv), K2HPO4 (209 mg, 1.20 mmol, 3.0 equiv), 9-mesityl-10-methylacridinium perchlorate (8.2 mg, 5.0 mol%), and [Co(dmgH)(dmgH2)Cl2] (11.6 mg, 8.0 mol%). After the vial was capped with a septum, it was evacuated and refilled with N2 for three times before DCE (1.5 mL) and H2O (0.5 mL) were added sequentially. If the heterocyclic substrate 1 was a liquid, it was added at this point. The mixture was degassed and stirred for 24 h under visible light irradiation (Kessil A360N, see Figure S-1 in the Supporting Information). After 24 h, the mixture was diluted with CH2Cl2 (10 mL) and H2O (10 mL), and the phases were separated. The aqueous layer was extracted with CH2Cl2 (2 × 10 mL), the combined organic phases were dried (Na2SO4), and the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (n-pentane or n-hexane/Et2O 20:1 to 2:1) affording the corresponding product 3.

131106-70-2 6-(Trifluoromethyl)benzo[d]thiazole 14810650, athiazole compound, is more and more widely used in various fields.

Reference：
Article; Koeller, Julian; Gandeepan, Parthasarathy; Ackermann, Lutz; Synthesis; vol. 51; 5; (2019); p. 1284 – 1292;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica