Category: 133046-46-5

133046-46-5, Name is Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate, molecular formula is C7H6F3NO2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 133046-46-5, Safety of Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate

Transition metal?catalyzed arene functionalization has been widely used for molecular synthesis over the past century. In this arena, copper catalysis has long been considered a privileged platform due to the propensity of high-valent copper to undergo reductive elimination with a wide variety of coupling fragments. However, the sluggish nature of oxidative addition has limited copper?s capacity to broadly facilitate haloarene coupling protocols. Here, we demonstrate that this copper oxidative addition problem can be overcome with an aryl radical?capture mechanism, wherein the aryl radical is generated through a silyl radical halogen abstraction. This strategy was applied to a general trifluoromethylation of aryl bromides through dual copper-photoredox catalysis. Mechanistic studies support the formation of an open-shell aryl species.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Safety of Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate. In my other articles, you can also check out more blogs about 133046-46-5

Reference：
Thiazole | C3H7887NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 133046-46-5, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 133046-46-5, Name is Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate, molecular formula is C7H6F3NO2S. In a Patent，once mentioned of 133046-46-5

Compounds of formula (I); which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 133046-46-5 is helpful to your research., Related Products of 133046-46-5

Reference：
Thiazole | C3H7901NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 133046-46-5, Name is Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate,molecular formula is C7H6F3NO2S, is a conventional compound. this article was the specific content is as follows.SDS of cas: 133046-46-5

Compounds of general formula (I), wherein R1, R11, Y, R2, n and A are as defined herein are useful as inhibitors or metallo-beta-lactamase (MBL) enzymes and can be used for reducing or removing antibiotic resistance in bacteria.

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Reference：
Thiazole | C3H7900NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 133046-46-5. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 133046-46-5, Name is Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate. In a document type is Patent, introducing its new discovery.

The present invention relates to pharmaceutical agents administered to a subject either in combination or in series for the treatment of a Respiratory Syncytial Virus (RSV) infection, wherein treatment comprises administering a compound effective to inhibit the function of the RSV and an additional compound or combinations of compounds having anti-RSV activity.

If you are interested in 133046-46-5, you can contact me at any time and look forward to more communication.Electric Literature of 133046-46-5

Reference：
Thiazole | C3H7889NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 133046-46-5. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 133046-46-5, Name is Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate. In a document type is Patent, introducing its new discovery.

The present invention relates to pharmaceutical agents administered to a subject either in combination or in series for the treatment of a Respiratory Syncytial Virus (RSV) infection, wherein treatment comprises administering a compound effective to inhibit the function of the RSV and an additional compound or combinations of compounds having anti-RSV activity.

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Reference：
Thiazole | C3H7889NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 133046-46-5, Name is Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate,molecular formula is C7H6F3NO2S, is a conventional compound. this article was the specific content is as follows.SDS of cas: 133046-46-5

Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.

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Reference：
Thiazole | C3H7897NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 133046-46-5, Name is Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate,molecular formula is C7H6F3NO2S, is a conventional compound. this article was the specific content is as follows.SDS of cas: 133046-46-5

The present invention provides PAR4 agonist peptides. These peptides are useful for developing robust PAR4 receptor assays.

The present invention provides PAR4 agonist peptides. These peptides are useful for developing robust PAR4 receptor assays.

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Reference£º
Thiazole | C3H7891NS – PubChem,
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133046-46-5,Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

Ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylate (80 mg) in ethanol (1 ml) was treated with 2N sodium hydroxide (0.706 ml) and the solution stirred at room temperature for 18 h. 2M Hydrochloric acid (0.54 ml) was added and the mixture blown down to dryness. The residue was dried under vacuum over phosphorous pentoxide and was then suspended in dry dichloromethane (1 ml) and treated at room temperature with oxalyl chloride (0.032 ml) and DMF (1 drop). The mixture was stirred at room temperature for 30 mins and then added dropwise to a solution of Intermediate 16 (98 mg) in acetonitrile (2 ml) and the mixture was stirred at room temperature for 22 h. The mixture was diluted with dichloromethane (15 ml), washed with brine (2¡Á15 ml) and blown down to dryness. The residue was purified by mass directed autoprep HPLC followed by SPE cartridge (5 g, aminopropyl) eluting with methanol. The eluent was blown down to dryness to give Example 339 as a brown gum (96 mg). LCMS showed MH+=483; TRET=2.57 min.

133046-46-5, The synthetic route of 133046-46-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Edlin, Christopher David; Holman, Stuart; Jones, Paul Spencer; Keeling, Suzanne Elaine; Lindvall, Mika Kristian; Mitchell, Charlotte Jane; Trivedi, Naimisha; US2009/131431; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica