139670-03-4归档 - Heterocyclic Building Blocks-Thiazole

Final Thoughts on Chemistry for 139670-03-4

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Formula: C3HBrClNS. In my other articles, you can also check out more blogs about 139670-03-4

139670-03-4, Name is 2-Bromo-4-chlorothiazole, molecular formula is C3HBrClNS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 139670-03-4, Formula: C3HBrClNS

Optimization of Novel 1-Methyl-1 H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber’s Pole Worm

A phenotypic screen of a diverse library of small molecules for inhibition of the development of larvae of the parasitic nematode Haemonchus contortus led to the identification of a 1-methyl-1H-pyrazole-5-carboxamide derivative with an IC50 of 0.29 muM. Medicinal chemistry optimization targeted modifications on the left-hand side (LHS), middle section, and right-hand side (RHS) of the scaffold in order to elucidate the structure-activity relationship (SAR). Strong SAR allowed for the iterative and directed assembly of a focus set of 64 analogues, from which compound 60 was identified as the most potent compound, inhibiting the development of the fourth larval (L4) stage with an IC50 of 0.01 muM. In contrast, only 18% inhibition of the mammary epithelial cell line MCF10A viability was observed, even at concentrations as high as 50 muM.

Reference：
Thiazole | C3H2426NS – PubChem,
Thiazole | chemical compound | Britannica

Final Thoughts on Chemistry for 139670-03-4

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 139670-03-4 is helpful to your research., Safety of 2-Bromo-4-chlorothiazole

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.139670-03-4, Name is 2-Bromo-4-chlorothiazole, molecular formula is C3HBrClNS. In a Patent，once mentioned of 139670-03-4, Safety of 2-Bromo-4-chlorothiazole

TRICYCLIC COMPOUNDS

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Reference：
Thiazole | C3H2424NS – PubChem,
Thiazole | chemical compound | Britannica

Simple exploration of 139670-03-4

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 139670-03-4, help many people in the next few years., Related Products of 139670-03-4

Related Products of 139670-03-4, An article , which mentions 139670-03-4, molecular formula is C3HBrClNS. The compound – 2-Bromo-4-chlorothiazole played an important role in people’s production and life.

The present disclosure a Syk compound inhibitors, including state cancer and inflammation and various disease States thereof in the treatment of relates to the use of. In one aspect a particular embodiment, . given by formula I which is marked as a chemical structure of compound. In formula said, X 1, X 2, X 3, R 2, R 3, R 4, R 5, and Y has described herein is. The present disclosure of a formula I compounds or a pharmaceutically acceptable salt of pharmaceutical compositions including, mediated by Syk and to treat conditions a employing these compounds and compositions further provides a method. (by machine translation)

Reference£º
Thiazole | C3H2425NS – PubChem,
Thiazole | chemical compound | Britannica

Some tips on 139670-03-4

139670-03-4, As the paragraph descriping shows that 139670-03-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139670-03-4,2-Bromo-4-chlorothiazole,as a common compound, the synthetic route is as follows.

Isopropylmagnesium chloride lithium chloride complex solution (4.58 mL, 5.95 mmol) was added slowly to a suspension of 3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-N-methoxy-N-methylpropanamide (784 mg, 1.983 mmol) and 2-bromo-4-chlorothiazole (Intermediate Q, step 2) (394 mg, 1.983 mmol) in THF (30 mL). The mixture was stirred at room temperature for 40 mins. The reaction mixture was quenched with saturated NH4Cl(aq) and extracted with EtOAc (2¡Á). The combined organic extracts were washed with brine, dried over sodium sulphate and evaporated under vacuum. Purification by chromatography on silica, eluting with 10-60% EtOAc/hexane afforded the title compound. [1181] 1H NMR (400 MHz, CDCl3) delta 7.79-7.59 (4H, mult), 7.51 (1H, s), 6.51 (1H, s), 4.41 (2H, t), 3.50 (2H, t), 3.41 (3H, s), 3.35 (3H, s) [1182] LC-MS Rt 1.20 mins [M+H]+ 454.0 (Method 2minLowpHv03)

139670-03-4, As the paragraph descriping shows that 139670-03-4 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; AHMED, Mahbub; ASHALL-KELLY, Alexander; GUERITZ, Louisa; MCKENNA, Jeffrey; MCKENNA, Joseph; MUTTON, Simon; PARMAR, Rakesh; SHEPHERD, Jon; WRIGHT, Paul; US2014/171417; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Brief introduction of 139670-03-4

139670-03-4 2-Bromo-4-chlorothiazole 15141964, athiazole compound, is more and more widely used in various fields.

139670-03-4, 2-Bromo-4-chlorothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,139670-03-4

Isopropylmagnesium chloride lithium chloride complex solution (1.3M, 2.93 mL, 3.81 mmol) was added dropwise to a solution of 3-(1,3-dimethyl-2,4-dioxo-5-phenyl-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-N-methoxy-N-methylpropanamide (470 mg, 1.269 mmol) and 2-bromo-4-chlorothiazole (Intermediate Q) (252 mg, 1.269 mmol) in THF (20 mL). The mixture was stirred at room temperature for 45 mins. The reaction was quenched with saturated NH4Cl(aq) and extracted with EtOAc (2¡Á). The combined organic extracts were washed with brine, dried over sodium sulfate and evaporated under vacuum. Purification by chromatography on silica, eluting with 20-70% EtOAc/hexane afforded the title compound. [1052] LC-MS Rt 1.29 mins; [M+H]+ 429.2 (Method 2minLowpHv03)

139670-03-4 2-Bromo-4-chlorothiazole 15141964, athiazole compound, is more and more widely used in various fields.