Category: 1416134-49-0

COA of Formula: C13H19N3O2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxamide, is researched, Molecular C13H19N3O2, CAS is 1416134-49-0, about Development of a Manufacturing Route to Avibactam, a β-Lactamase Inhibitor.

Process development work to provide an efficient, robust, and cost-effective manufacturing route to avibactam, a β-lactamase inhibitor is presented herewith. Aspects of this optimization work include the counterintuitive introduction of a protecting group to effect a difficult urea formation and the use of controlled feed hydrogenation conditions to facilitate an elegant one pot debenzylation and sulfation reaction. Overall, the com. process delivers avibactam in much improved yield with significant reduction in the environmental footprint.

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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ball, Matthew; Boyd, Alistair; Ensor, Gareth J.; Evans, Matthew; Golden, Michael; Linke, Simon R.; Milne, David; Murphy, Rebecca; Telford, Alex; Kalyan, Yuriy; Lawton, Graham R.; Racha, Saibaba; Ronsheim, Melanie; Zhou, Shao Hong published the article 《Development of a Manufacturing Route to Avibactam, a β-Lactamase Inhibitor》. Keywords: avibactam preparation.They researched the compound: (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxamide( cas:1416134-49-0 ).HPLC of Formula: 1416134-49-0. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1416134-49-0) here.

Process development work to provide an efficient, robust, and cost-effective manufacturing route to avibactam, a β-lactamase inhibitor is presented herewith. Aspects of this optimization work include the counterintuitive introduction of a protecting group to effect a difficult urea formation and the use of controlled feed hydrogenation conditions to facilitate an elegant one pot debenzylation and sulfation reaction. Overall, the com. process delivers avibactam in much improved yield with significant reduction in the environmental footprint.

After consulting a lot of data, we found that this compound(1416134-49-0)HPLC of Formula: 1416134-49-0 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wang, Tao; Du, Liang-Dong; Wan, Ding-jian; Li, Xiang; Chen, Xin-Zhi; Wu, Guo-Feng published an article about the compound: (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxamide( cas:1416134-49-0,SMILESS:O=C([C@H]1NC[C@H](NOCC2=CC=CC=C2)CC1)N ).Recommanded Product: (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxamide. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1416134-49-0) through the article.

An efficient synthesis of avibactam starting from com. available ethyl-5-hydroxypicolinate was completed in ten steps and 23.9% overall yield. The synthesis features a novel lipase-catalyzed resolution, in the preparation of (2S,5S)-5-hydroxypiperidine-2-carboxylate acid, which are valuable precursors of the key intermediate Et (2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxylate. An optimized one-pot debenzylation / sulfation reaction, followed by cation exchange, gave the avibactam sodium salt on a 400.0 g scale.

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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1416134-49-0, is researched, Molecular C13H19N3O2, about Use of Lipase Catalytic Resolution in the Preparation of Ethyl (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxylate, a Key Intermediate of the β-Lactamase Inhibitor Avibactam, the main research direction is lipase ethyl benzyloxyaminopiperidinecarboxylate intermediate lactamase inhibitor avibactam.Electric Literature of C13H19N3O2.

Here we describe an efficient and cost-effective chemoenzymic synthesis of the β-lactamase inhibitor avibactam starting from com. available Et 5-hydroxypicolinate hydrochloride. Avibactam was synthesized in 10 steps with an overall yield of 23.9%. The synthetic route features a novel lipase-catalyzed resolution step during the preparation of (2S,5S)-Et 5-hydroxypiperidine-2-carboxylate, a valuable precursor of the key intermediate Et (2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxylate. Our synthetic route was used to produce 400 g of avibactam sodium salt.

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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1416134-49-0, is researched, Molecular C13H19N3O2, about Use of Lipase Catalytic Resolution in the Preparation of Ethyl (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxylate, a Key Intermediate of the β-Lactamase Inhibitor Avibactam, the main research direction is lipase ethyl benzyloxyaminopiperidinecarboxylate intermediate lactamase inhibitor avibactam.SDS of cas: 1416134-49-0.

Here we describe an efficient and cost-effective chemoenzymic synthesis of the β-lactamase inhibitor avibactam starting from com. available Et 5-hydroxypicolinate hydrochloride. Avibactam was synthesized in 10 steps with an overall yield of 23.9%. The synthetic route features a novel lipase-catalyzed resolution step during the preparation of (2S,5S)-Et 5-hydroxypiperidine-2-carboxylate, a valuable precursor of the key intermediate Et (2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxylate. Our synthetic route was used to produce 400 g of avibactam sodium salt.

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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wang, Tao; Du, Liang-Dong; Wan, Ding-jian; Li, Xiang; Chen, Xin-Zhi; Wu, Guo-Feng researched the compound: (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxamide( cas:1416134-49-0 ).SDS of cas: 1416134-49-0.They published the article 《A New Synthetic Route to Avibactam: Lipase Catalytic Resolution and the Simultaneous Debenzylation/Sulfation》 about this compound( cas:1416134-49-0 ) in Organic Process Research & Development. Keywords: Avibactam sodium improved scalable synthesis Lipase catalytic resolution; Lipase catalytic resolution simultaneous debenzylation sulfation scalable Avibactam preparation. We’ll tell you more about this compound (cas:1416134-49-0).

An efficient synthesis of avibactam starting from com. available ethyl-5-hydroxypicolinate was completed in ten steps and 23.9% overall yield. The synthesis features a novel lipase-catalyzed resolution, in the preparation of (2S,5S)-5-hydroxypiperidine-2-carboxylate acid, which are valuable precursors of the key intermediate Et (2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxylate. An optimized one-pot debenzylation / sulfation reaction, followed by cation exchange, gave the avibactam sodium salt on a 400.0 g scale.

There are many compounds similar to this compound(1416134-49-0)SDS of cas: 1416134-49-0. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Recommanded Product: 1416134-49-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxamide, is researched, Molecular C13H19N3O2, CAS is 1416134-49-0, about A New Synthetic Route to Avibactam: Lipase Catalytic Resolution and the Simultaneous Debenzylation/Sulfation. Author is Wang, Tao; Du, Liang-Dong; Wan, Ding-jian; Li, Xiang; Chen, Xin-Zhi; Wu, Guo-Feng.

An efficient synthesis of avibactam starting from com. available ethyl-5-hydroxypicolinate was completed in ten steps and 23.9% overall yield. The synthesis features a novel lipase-catalyzed resolution, in the preparation of (2S,5S)-5-hydroxypiperidine-2-carboxylate acid, which are valuable precursors of the key intermediate Et (2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxylate. An optimized one-pot debenzylation / sulfation reaction, followed by cation exchange, gave the avibactam sodium salt on a 400.0 g scale.

There is still a lot of research devoted to this compound(SMILES：O=C([C@H]1NC[C@H](NOCC2=CC=CC=C2)CC1)N)Recommanded Product: 1416134-49-0, and with the development of science, more effects of this compound(1416134-49-0) can be discovered.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

SDS of cas: 1416134-49-0. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxamide, is researched, Molecular C13H19N3O2, CAS is 1416134-49-0, about Development of a Manufacturing Route to Avibactam, a β-Lactamase Inhibitor. Author is Ball, Matthew; Boyd, Alistair; Ensor, Gareth J.; Evans, Matthew; Golden, Michael; Linke, Simon R.; Milne, David; Murphy, Rebecca; Telford, Alex; Kalyan, Yuriy; Lawton, Graham R.; Racha, Saibaba; Ronsheim, Melanie; Zhou, Shao Hong.

Process development work to provide an efficient, robust, and cost-effective manufacturing route to avibactam, a β-lactamase inhibitor is presented herewith. Aspects of this optimization work include the counterintuitive introduction of a protecting group to effect a difficult urea formation and the use of controlled feed hydrogenation conditions to facilitate an elegant one pot debenzylation and sulfation reaction. Overall, the com. process delivers avibactam in much improved yield with significant reduction in the environmental footprint.

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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 1416134-49-0. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxamide, is researched, Molecular C13H19N3O2, CAS is 1416134-49-0, about Use of Lipase Catalytic Resolution in the Preparation of Ethyl (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxylate, a Key Intermediate of the β-Lactamase Inhibitor Avibactam. Author is Wang, Tao; Du, Liang-Dong; Wan, Ding-jian; Li, Xiang; Chen, Xin-Zhi; Wu, Guo-Feng.

Here we describe an efficient and cost-effective chemoenzymic synthesis of the β-lactamase inhibitor avibactam starting from com. available Et 5-hydroxypicolinate hydrochloride. Avibactam was synthesized in 10 steps with an overall yield of 23.9%. The synthetic route features a novel lipase-catalyzed resolution step during the preparation of (2S,5S)-Et 5-hydroxypiperidine-2-carboxylate, a valuable precursor of the key intermediate Et (2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxylate. Our synthetic route was used to produce 400 g of avibactam sodium salt.

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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Safety of (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxamide. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxamide, is researched, Molecular C13H19N3O2, CAS is 1416134-49-0, about Use of Lipase Catalytic Resolution in the Preparation of Ethyl (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxylate, a Key Intermediate of the β-Lactamase Inhibitor Avibactam. Author is Wang, Tao; Du, Liang-Dong; Wan, Ding-jian; Li, Xiang; Chen, Xin-Zhi; Wu, Guo-Feng.

Here we describe an efficient and cost-effective chemoenzymic synthesis of the β-lactamase inhibitor avibactam starting from com. available Et 5-hydroxypicolinate hydrochloride. Avibactam was synthesized in 10 steps with an overall yield of 23.9%. The synthetic route features a novel lipase-catalyzed resolution step during the preparation of (2S,5S)-Et 5-hydroxypiperidine-2-carboxylate, a valuable precursor of the key intermediate Et (2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxylate. Our synthetic route was used to produce 400 g of avibactam sodium salt.

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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica