Category: 1452-15-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1452-15-9,4-Cyanothiazole,as a common compound, the synthetic route is as follows.

General procedure: Trifluoroacetic acid (4 mL) was added to a mixture of nitrile(1.0 mmol) and thiosemicarbazide (1.1 mmol). The reaction mixturewas stirred and refluxed for 6 h. Then, it was cooled to roomtemperature and aqueous ammonia was added. The precipitatedsolidwas filtered,washed with hot water and air-dried. It should benoted that the compounds f1-f35 were directly used for the nextreaction without further purification., 1452-15-9

1452-15-9 4-Cyanothiazole 15069, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Chen, Ya; Kirchmair, Johannes; Li, Xueyao; Ma, Guixing; Wu, Song; Xia, Jie; Xue, Wenjie; Zhang, Hongmin; European Journal of Medicinal Chemistry; vol. 188; (2020);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1452-15-9, 4-Cyanothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 4-cyanothiazole (5.0 g, 45.0mmol) in o-dichlorobenzene (40.0 mL) was added the respective aniline (1) (49.0 mmol). The reaction mixture was heated at 135 C with purging excess dry HCl for 3 h. Then, cooled the reaction mixture to 40 C and the resulting solids were filtered, washed with more o-dichlorobenzene (10.0 mL). The solids were dried at 90 C under vacuum to give amidine hydrochlorides with yields in the 70-90% range., 1452-15-9

1452-15-9 4-Cyanothiazole 15069, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Patil, Vikrant; Barragan, Enrique; Patil, Shivaputra A.; Patil, Siddappa A.; Bugarin, Alejandro; Tetrahedron Letters; vol. 58; 35; (2017); p. 3474 – 3477;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1452-15-9, 4-Cyanothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1452-15-9, Preparation of Products; To a mixture of nitrile (60 mg) and substituted aniline (leq) was added AlCl3 (leq). The mixture was heated up to 2000C and stirred for 20 min under N2. The mixture was cooled and the product purified by preparative HPLC.

As the paragraph descriping shows that 1452-15-9 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME LIMITED; WO2007/138343; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica