Category: 1452-16-0

Tang, Meizhu et al. published their research in Dyes and Pigments in 2019 | CAS: 1452-16-0

2-Cyanothiazole (cas: 1452-16-0) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Reference of 1452-16-0

Diketopyrrolopyrrole based small molecular semiconductors containing thiazole units for solution-processed n-channel thin-film transistors was written by Tang, Meizhu;Wu, Sicheng;Xing, Weilong;Shen, Hongguang;Xiang, Lanyi;Liang, Yingying;Xu, Wei;Zhu, Daoben. And the article was included in Dyes and Pigments in 2019.Reference of 1452-16-0 This article mentions the following:

In this work, three diketopyrrolopyrrole-based conjugated small mol. semiconductors characterized by the combination of a diketopyrrolopyrrole (DPP) central core, thiazole π-conjugated moiety, and dicyanovinyl end group with different alkyl side chain substituents, 2TzDPPA1-2DCV, 2TzDPPA2-2DCV, and 2TzDPPA3-2DCV were synthesized. These small mols. have a similar narrow band gap of about 1.50 eV and deep LUMO energy level at -4.30 eV. Under ambient conditions, electron mobilities of 0.28 cm2 V-1 s-1, 0.13 cm2 V-1 s-1, 0.25 cm2 V-1 s-1 for solution processed thin films of 2TzDPPA1-2DCV, 2TzDPPA2-2DCV, and 2TzDPPA3-2DCV were obtained, due to high crystallinity and well-organized mol. stacking. Compared with the other two materials, thin films of 2TzDPPA1-2DCV enable the best OFET performance with desirable Ion/Ioff rates exceeding of 107, attribute to the coefficient of smoother film morphol. and stronger crystallinity. These results reveal that introducing the thiazole unit into the DPP-based conjugated skeleton is conducive to enhance the crystallinity and tailor LUMO energy levels which ensure good performance and excellent stability of these mols. as active materials for n-channel electronic devices. In the experiment, the researchers used many compounds, for example, 2-Cyanothiazole (cas: 1452-16-0Reference of 1452-16-0).

2-Cyanothiazole (cas: 1452-16-0) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Reference of 1452-16-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Brief introduction of 1452-16-0

1452-16-0 2-Cyanothiazole 15111480, athiazole compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1452-16-0,2-Cyanothiazole,as a common compound, the synthetic route is as follows.

A mixture of 5 mg iron trichloride (FeCI3), 2 g of sodium and 40 ml of t-amylalcohol is heated to 110 0C for 20 minutes before a mixture of 3.9 g of the thiazole-2-nitrile of the formula 1 and 7.82 g of 8 is added portion-wise. The reaction mixture is stirred at 1 10 0C for 3 hours before it is poured onto 6.3 g acetic acid in a water-methanol mixture (100ml/100ml). Bchner filtration and exhaustive washing with methanol affords 4.5 g of the desired 1 ,4- diketopyrrolo[3,4-c]pyrrole (DPP) derivative of the formula A-42 as dark blue powder; ESI- MS m/z (% int.): 302.15 ([M+H]+, 100%)., 1452-16-0

1452-16-0 2-Cyanothiazole 15111480, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; BASF SE; HAYOZ, Pascal; AEBISCHER, Olivier Frederic; DUeGGELI, Mathias; TURBIEZ, Mathieu G. R.; FONRODONA TURON, Marta; CHEBOTAREVA, Natalia; WO2010/115767; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Some tips on 1452-16-0

As the paragraph descriping shows that 1452-16-0 is playing an increasingly important role.

1452-16-0, 2-Cyanothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 2.5 M solution of nBuLi (2.0 eq) in hexane was added under argon to a solution of 2,2-dimethoxyethanamine (2.0 eq) in THF at -78C. After stirring for 30 min, thiazole-2-carbonitrile (2-Im-2, 3.0 g, 1.0 eq) was added and the resulting solution was stirred at 0 C for 2h, then quenched with 20 mL of 5% MeOH in water. The volatiles were removed and 6N HC1 was added to adjust to pH=l. The acidic solution was refluxed overnight, cooled to rt then poured into a mixture of ice and aqueous a2C03. This was extracted with EtOAc and the organic layer was concentrated to give Imadazole 2. LCMS (0.01% Ammonia): 152.1 m/z (M+H)+; ?-NMR (DMSO-d6, 500MHz): delta: 13.19 (bs, 1H), 7.98 (d, 1H, J=3.0Hz), 7.82 (d, 1H, J=3.0Hz), 7.36 (s, 1H), 7.14 (s, 1H)., 1452-16-0

As the paragraph descriping shows that 1452-16-0 is playing an increasingly important role.

Reference£º
Patent; ELAN PHARMACEUTICALS, INC.; GALEMMO, Robert, A., Jr.; ARTIS, Dean, Richard; YE, Xiaocong, Michael; AUBELE, Danielle, L.; TRUONG, Anh, P.; BOWERS, Simeon; HOM, Roy, K.; ZHU, Yong-Liang; NEITZ, R., Jeffrey; SEALY, Jennifer; ADLER, Marc; BEROZA, Paul; ANDERSON, John, P.; WO2011/79114; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

New learning discoveries about 1452-16-0

1452-16-0, The synthetic route of 1452-16-0 has been constantly updated, and we look forward to future research findings.

1452-16-0, 2-Cyanothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of thiazole-2-carbonitrile (1.5 g, 14 mmol) in 5 mL of dry MeOH was added dropwise a solution of sodium methoxide (0.74 g, 14 mmol) in 10 mL of dry methanol. The reaction mixture was stirred at room temperature until the disappearance of starting material monitored by LC/MS. After that, ammonium chloride (1.5 g, 28 mmol) was added in one portion and the reaction mixture was stirred overnight. The undissolved material was removed by filtration and the filtrate was concentrated to afford thiazole-2-carboxamidine hydrochloride (Compound A) as a grey solid which was used directly in the next step without further purification. MS: calc’d 128 (MH+), measured 128 (MH+).

1452-16-0, The synthetic route of 1452-16-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HOFFMANN-LA ROCHE INC.; Guo, Lei; Hu, Taishan; Hu, Yimin; Kocer, Buelent; Kou, Buyu; Li, Gangqin; Lin, Xianfeng; Liu, Haixia; Shen, Hong; Shi, Houguang; Wu, Guolong; Zhang, Zhisen; Zhou, Mingwei; Zhu, Wei; US2014/343032; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica