Category: 14527-43-6

14527-43-6, Ethyl thiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 13 (108.25?g, 0.689?mol) in THF (344?mL) was added dropwise to a suspension of LiAlH4 (26.3?g, 0.692?mmol) in THF (344?mL) at 0?C. The reaction mixture was stirred for 30?min?at 0?C (at this point TLC indicated consumption of the SM). It was then quenched by successive addition of EtOAc (50?mL), water (26?mL), 10% NaOH (26?mL) solution, and water (78?mL) (the temperature should not exceed 0?C). The precipitate was filtered and washed several times with THF. The filtrate was evaporated to give 8, which was used without purification. M?=?43.25?g. Yield?=?54%., 14527-43-6

The synthetic route of 14527-43-6 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Curreli, Francesca; Belov, Dmitry S.; Kwon, Young Do; Ramesh, Ranjith; Furimsky, Anna M.; O’Loughlin, Kathleen; Byrge, Patricia C.; Iyer, Lalitha V.; Mirsalis, Jon C.; Kurkin, Alexander V.; Altieri, Andrea; Debnath, Asim K.; European Journal of Medicinal Chemistry; vol. 154; (2018); p. 367 – 391;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14527-43-6,Ethyl thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

Methyl Iodide (140?mL, 2.25?mol, 5.0 equiv) was dissolved in Et2O (450?mL) and added dropwise to Mg turnings (54.3?g, 2.25?mol, 5.0 equiv) under a constant flow of nitrogen. When all magnesium dissolves ester 13 (70.24?g, 447?mmol) in Et2O (450?mL) was added dropwise. The reaction mixture was left overnight and resulted suspension was carefully (very exothermic + gas evolution.) was poured into saturated aqueous NH4Cl (~2?L). The resulted solution was extracted with Et2O (3?*?200?mL). The combined organic layers were dried over Na2SO4 and evaporated to give the pure compound. M?=?48.26?g. Yield?=?75%. 1H NMR: (CDCl3, 400?MHz) delta?=?1.61 (s, 6?H), 3.27 (br. s, 1?H), 7.17 (d, J?=?2.0?Hz, 1?H), 8.73 (d, J?=?1.8?Hz, 1?H). 13C NMR: (CDCl3, 100?MHz) delta?=?30.2 (2C), 71.2, 77.2, 111.6, 152.9, 165.0., 14527-43-6

The synthetic route of 14527-43-6 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Curreli, Francesca; Belov, Dmitry S.; Kwon, Young Do; Ramesh, Ranjith; Furimsky, Anna M.; O’Loughlin, Kathleen; Byrge, Patricia C.; Iyer, Lalitha V.; Mirsalis, Jon C.; Kurkin, Alexander V.; Altieri, Andrea; Debnath, Asim K.; European Journal of Medicinal Chemistry; vol. 154; (2018); p. 367 – 391;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14527-43-6,Ethyl thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

The thiazole-4-methanol used as a starting material was prepared as follows:- Lithium aluminium hydride (1M solution THF, 1.5 mL) was added slowly to a stirred solution of ethyl thiazole-4-carboxylate (224 mg) in THF (4 mL) cooled to 0C. The reaction mixture was stirred and allowed to wann to room temperature over 1 hour. Ethyl acetate (20 mL) was added to the reaction mixture followed by water (1 mL), 2M NaOH solution (2 mL) then water (3 mL). A precipitate formed which was filtered off through Celite (iT). The filtrate was concentrated to give the title compound (150 mg, 92%); NMR Spectrum : (DMSOd6) 4.12 (s, 2H), 7.47 (s, 1H), 9. 03 (s, 1H)., 14527-43-6

As the paragraph descriping shows that 14527-43-6 is playing an increasingly important role.

Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/61465; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica