Category: 14527-44-7

14527-44-7, Methyl thiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-(5-(4-Methoxybenzyloxy) pyridin-2-yl)thiazole-5-carboxylate A mixture of 2-bromo-5-(4-methoxybenzyloxy)pyridine (1.10 g), methyl thiazole-5-carboxylate (644 mg), Pd(P(t-Bu)3)2 (153 mg), Cs2CO3 (1.20 g) and DMF (10 mL) was evacuated and refilled with nitrogen three times. The mixture was stirred at 150 C. under N2 atmosphere for 3 hours. Insoluble material was removed by filtration through Celite. The filtrate was diluted with H2O (100 mL). The solid obtained was collected by filtration and washed with MeOH to provide the subtitle compound. MS ESI+: m/z=357 [M+H]+., 14527-44-7

The synthetic route of 14527-44-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SANOFI; SCHWINK, Lothar; BOSSART, Martin; GLOMBIK, Heiner; GOSSEL, Matthias; KADEREIT, Dieter; KLABUNDE, Thomas; MAIER, Thomas; STENGELIN, Siegfried; US2014/99333; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14527-44-7,Methyl thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Part C Preparation of 5-thiazolemethanol To a solution of 11.73 g (82 mmol) of methyl 5-thiazolylcarboxylate in 105 mL of anhydrous tetrahydrofuran at 0 C. under nitrogen, was added 90 mL (90 mmol) of a 1.0M lithium aluminum hydride solution in diethyl ether over a 35 minute period. After stiiring at room temperature for 30 minutes, the solution was cooled to 0 C., and carefully quenched by the addition of 3 mL of water, 3 mL of 20% sodium hydroxide solution, and 6 mL of water, then 100 mL of tetrahydrofuran was added. After stirring for 1 hour, the mixture was filtered, the solid was washed with tetrahydrofuran, and the filtrate concentrated to afford 7.56 g of 5-thiazolylmethanol.

14527-44-7, The synthetic route of 14527-44-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; G. D. Searle & Co.; US5968942; (1999); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

14527-44-7, Methyl thiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

10231] Procedure:10232] Pd(OAc)2 (3.9 mg, 0.017 mmoles), [P(t-13u)3H] HF4 (10.0mg, 0.035 mmoles), 1-adamantanecarboxylic acid (18.4 mg, 0.10 mmoles), K2C03 (96.5 mg, 0.70 mmoles), methyl thiazole-5-carboxylate (50 mg, 0.35 mmoles), and methyl 6-bromonicotinate (113 mg, 0.52 mmoles) were added to a dried flask. The flask was fitted with a reflux condenser capped with a septum, evacuated, and purged with nitrogen (.-5 times). Dry toluene (1.7 mE) was added via syringe, and the reaction was stirred at 110 C. for 48 h. The reaction mixture was cooled and filtered through Celite, and the filtrate was concentrated under reduced pressure. The crude product was then purified by chromatography on silica (3% acetone in 1:1 DCMlhexanes) to afford the title compound (28 mg, 29%) as a white solid. ?H NMR (400 MHz, CDC13) 0 9.22 (s, 1H), 8.51 (s, 1H), 8.43 (dd, J=2.0, 8.0 Hz, 1H), 8.29 (d, J=8.0 Hz, 1H), 4.00 (s, 3H), 3.96 (s, 3H); ?3C NMR (100 MHz, CDC13) 0 172.7, 165.1,161.8, 153.6, 150.9, 149.7, 138.4, 131.7, 127.1, 119.6, 52.6, 52.6; HRMS (ESI) m/z 279.0439 [calc?d for C,2H,,N204S (M+H) 279.0435].10233] For experiments with mammalian cells, this compound was recrystallized from EtOAc to afford a whitecrystalline solid., 14527-44-7

As the paragraph descriping shows that 14527-44-7 is playing an increasingly important role.

Reference：
Patent; WISCONSIN ALUMNI RESEARCH FOUNDATION; RAINES, Ronald T.; Vasta, James; (50 pag.)US2016/280701; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14527-44-7,Methyl thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

A solution of FeSO4·7H2O (33.4 g, 120 mmol) in 80 ml H2O and 70% tert-butyl hydroperoxide (12 ml, 120 mmol) were added to a stirred and cooled (10-20 ) mixture of the methyl-thiazole-5-carboxylate 6 (2.86 g, 20 mmol), 4 M H2SO4 (10 ml), and the 40% aldehyde (13.22 g, 120 mmol) separately and simultaneously. The reaction mixture was stirred at room temperature (25 ) for 1 h, extracted with EtOAc and washed with saturated Na2S2O3 solution and brine. After drying over anhydrous Na2SO4 and removing the solvent, a crude material was obtained. The material was purified by column chromatography (PE:EtOAc, 50:1, v/v) to afford compound 7 (2.97 g, 80%) as pale yellow solid. MS (ESI) m/z 186.0 [M+H]+. 1H NMR (400 Hz, CDCl3) delta 8.50 (s, 1H), 3.95 (s, 3H), 2.73 (s, 3H) ., 14527-44-7

The synthetic route of 14527-44-7 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Chang, Shaohua; Zhang, Zhang; Zhuang, Xiaoxi; Luo, Jinfeng; Cao, Xianwen; Li, Honglin; Tu, Zhengchao; Lu, Xiaoyun; Ren, Xiaomei; Ding, Ke; Bioorganic and Medicinal Chemistry Letters; vol. 22; 2; (2012); p. 1208 – 1212;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14527-44-7,Methyl thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

A mixture of 2-bromo-5-(4-methoxybenzyloxy)pyridine (1 .10 g), methyl thiazole-5- carboxylate (644 mg), Pd(P(f-Bu)3)2 (153 mg), Cs2CO3 (1 .20 g) and DMF (10 mL) was evacuated and refilled with nitrogen three times. The mixture was stirred at 150C under N2 atmosphere for 3 hours. Insoluble material was removed by filtration through Celite. The filtrate was diluted with H2O (100 mL). The solid obtained was collected by filtration and washed with MeOH to provide the subtitle compound. MS ESI+: m/z = 357 [M+H]+.

14527-44-7, 14527-44-7 Methyl thiazole-5-carboxylate 331117, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; SANOFI; SCHWINK, Lothar; BOSSART, Martin; GLOMBIK, Heiner; GOSSEL, Matthias; KADEREIT, Dieter; KLABUNDE, Thomas; MAIER, Thomas; STENGELIN, Siegfried; WO2014/56938; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

14527-44-7, Methyl thiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Part C Preparation of 5-thiazolemethanol To a solution of 11.73 g (82 mmol) of methyl 5-thiazolylcarboxylate in 105 mL of anhydrous tetrahydrofuran at 0 C. under nitrogen, was added 90 mL (90 mmol) of a 1.0M lithium aluminum hydride solution in diethyl ether over a 35 minute period. After stirring at room temperature for 30 minutes, the solution was cooled to 0 C., and carefully quenched by the addition of 3 mL of water, 3 mL of 20% sodium hydroxide solution, and 6 mL of water, then 100 mL of tetrahydrofuran was added. After stirring for 1 hour, the mixture was filtered, the solid was washed with tetrahydrofuran, and the filtrate concentrated to afford 7.56 g of 5-thiazolylmethanol.

14527-44-7, The synthetic route of 14527-44-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; G.D. Searle & Co.; US6046190; (2000); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14527-44-7,Methyl thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Part C Preparation of 5-thiazolemethanol To a solution of 11.73 g (82 mmol) of methyl 5-thiazolylcarboxylate in 105 mL of anhydrous tetrahydrofuran at 0 C. under nitrogen, was added 90 mL (90 mmol) of a 1.0M lithium aluminum hydride solution in diethyl ether over a 35 minute period. After stiiring at room temperature for 30 minutes, the solution was cooled to 0 C., and carefully quenched by the addition of 3 mL of water, 3 mL of 20% sodium hydroxide solution, and 6 mL of water, then 100 mL of tetrahydrofuran was added. After stirring for 1 hour, the mixture was filtered, the solid was washed with tetrahydrofuran, and the filtrate concentrated to afford 7.56 g of 5-thiazolylmethanol., 14527-44-7

As the paragraph descriping shows that 14527-44-7 is playing an increasingly important role.

Reference：
Patent; G. D. Searle & Co.; US5968942; (1999); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

14527-44-7, Methyl thiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Part C Preparation of 5-thiazolemethanol To a solution of 11.73 g (82 mmol) of methyl 5-thiazolylcarboxylate in 105 mL of anhydrous tetrahydrofuran at 0 C. under nitrogen, was added 90 mL (90 mmol) of a 1.0M lithium aluminum hydride solution in diethyl ether over a 35 minute period. After stirring at room temperature for 30 minutes, the solution was cooled to 0 C., and carefully quenched by the addition of 3 mL of water, 3 mL of 20% sodium hydroxide solution, and 6 mL of water, then 100 mL of tetrahydrofuran was added. After stirring for 1 hour, the mixture was filtered, the solid was washed with tetrahydrofuran, and the filtrate concentrated to afford 7.56 g of 5-thiazolylmethanol., 14527-44-7

14527-44-7 Methyl thiazole-5-carboxylate 331117, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; G.D. Searle & Co.; US6046190; (2000); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

14527-44-7, Methyl thiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 0. 54 g of g-4 and 10ml tetrahydrofurane (THF) was stirred at 0C under a nitrogen atmosphere. The mixture of 0. 16g of lithium aluminium hydride and 5ml of ether was added drop wise. After lhour at 0C water and 20% sodium hydroxide were added, and stirred during 30 minutes. The mixture was filtered over decalite and the solvent was removed by azeotropique distillation with toluene yielding 0.3g (69%) of thiazol-5-yl-methanol (g-5).

14527-44-7, 14527-44-7 Methyl thiazole-5-carboxylate 331117, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; TIBOTEC PHARMACEUTICALS LTD; WO2003/97616; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14527-44-7,Methyl thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Step 1: Sodium 2-cyano-1-(1,3-thiazol-5-yl)ethenolate A solution of 1.5 g (10.5 mmol) of methyl 1,3-thiazole-5-carboxylate and 430 mg (10.8 mmol) of acetonitrile in 15 ml of THF was added dropwise to a suspension of 419 mg of sodium hydride (60% strength suspension in mineral oil) in 16 ml of THF which was heated under reflux. The reaction mixture was heated under reflux for 20 h. After cooling, 50 ml of methyl tert-butyl ether were added and the mixture was stirred for 30 minutes. The resulting precipitate was filtered off with suction through a frit and dried under oil pump vacuum. This gave 1.71 g (94% of theory) of the title compound which was combined with the product (3.48 g, 95% of theory) from a second batch starting with 3.0 g (21 mmol) of methyl 1,3-thiazole-5-carboxylate.

14527-44-7, As the paragraph descriping shows that 14527-44-7 is playing an increasingly important role.

Reference：
Patent; BAYER INTELLECTUAL PROPERTY GMBH; SUessMEIER, Frank; LOBELL, Mario; GRUeNEWALD, Sylvia; HAeRTER, Michael; BUCHMANN, Bernd; TELSER, Joachim; JOeRIssEN, Hannah; HEROULT, Melanie; KAHNERT, Antje; LUSTIG, Klemens; LINDNER, Niels; US2013/190290; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica