Category: 14542-13-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14542-13-3,2-Methoxythiazole,as a common compound, the synthetic route is as follows.

14542-13-3, Production Example 36 Synthesis of (2-methoxy-5-thiazolyl)ethyl bromide 2-Methoxythiazole (3.9 g) was treated as in the above Production Example 35 to give the title compound (1.4 g) as a brown oil (yield: 19%). 1H-NMR (400 MHz, CDCl3): delta(ppm) 3.20(2H, t, J=7Hz), 3.51(2H, t, J=7Hz), 4.03(3H, s), 6.89(1H, s).

The synthetic route of 14542-13-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Eisai Co., Ltd.; US2002/19531; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

14542-13-3, 2-Methoxythiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 2-methoxythiazole ( 5 g, 43.4 mmol) in tetrahydrofuran(THF) (50 mL) was added n-BuLi (35.3 mL, 56.4 mmol) and the contents stirred at -78 C.After 15 min, tributylchlorostannane (14.13 mL, 52.1 mmol) was added and the mixturestirred with warming to room temperature over a 3 h period. The reaction mixture wasquenched with water (20 mL) and the contents extracted with ether (25 mL ). The organic layer was separated and dried over anhydrous sodium sulphate, filtered, and the filtrateconcentrated in vacuo to afford the crude product (6 g). The crude product was purified bysilica gel column chromatography (eluent: 2% EtOAc/Hexane) to afford 2-methoxy-5-(tributylstannyl)thiazole (4 g, 22%) as yellow liquid. 1H NMR (400 MHz, CDCl3-d3) 8ppm 0.90-0.98 (m, 9H), 1.05-1.15 (m, 6H),1.30-1.40 (m, 6H), 1.50-1.65 (m, 6H), 4.04 (s, 3H), 7.03 (s, 1H). LCMS(ES) [M+Ht 405.99., 14542-13-3

14542-13-3 2-Methoxythiazole 575451, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; GLAXOSMITHKLINE LLC; BURGESS, Joelle, Lorraine; DUQUENNE, Celine; KNIGHT, Steven, David; MILLER, William, Henry; NEWLANDER, Kenneth, Allen; VERMA, Sharad, Kumar; WO2013/173441; (2013); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14542-13-3,2-Methoxythiazole,as a common compound, the synthetic route is as follows.,14542-13-3

To a stirred solution of compound 606-13a (20.0 g, 174 mmol) in anhydrous THF (700 mL) was added n-BuLi (2.5 M solution in hexanes, 70 mL, 175 mmol) dropwise over 20 min at -78 C (dry ice/acetone bath) under nitrogen. The resulting reaction mixture was stirred at -78 C under N2 for 2 h. After this time, I2 (44.2 g, 174 mmol) was added. The resulting mixture was slowly warmed to rt over 2 h and stirred at rt for 1 h. The reaction mixture was then cooled to 0 C and quenched by slow addition of saturated NH4Cl aqueous solution (300 mL). The resulting mixture was warmed to rt and extracted with EtOAc (500 mL). The extract was washed with 20% Na2S203 aqueous solution (300 mL) and brine (300 mL), dried over anhydrous Na2S04, filtered, and concentrated under reduced pressure (The product is volatile; evaporator bath temperature chromatography on silica gel eluting with 5% EtO Ac/hexanes (The product is volatile; evaporator bath temperature

As the paragraph descriping shows that 14542-13-3 is playing an increasingly important role.

Reference：
Patent; AGENEBIO, INC.; MEKONNEN, Belew; BUTERA, John, A.; HUANG, Jianxing; PATEL, Hemantbhai; JIANG, Qin; HERR, Robert, Jason; MAYHEW, Nicholas, James; FREEMAN, Emily, Elizabeth; (682 pag.)WO2019/246300; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica