Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 152300-59-9, C6H8N2O2S. A document type is Patent, introducing its new discovery., Application In Synthesis of Ethyl 4-aminothiazole-5-carboxylate
The invention belongs to the technical field of pharmaceutical intermediates, relates to a 4 – amino-thiazole – 5 – carboxylic acid ethyl ester synthesis method, steps which consists in: the 4 – amino – 2 – (methylthio) thiazole – 5 – carboxylic acid ethyl ester dissolved in ethanol, adding concentrated hydrochloric acid, adding zinc powder batches under stirring, reflux reaction for 4 hours, to obtain the neutralizing liquid; to the neutralizing liquid is filtered, the filter cake washing with ethanol for 2 – 3 times, the filtrate concentrated under reduced pressure, to obtain the concentrated solution; adding the concentrated in methylene chloride and water, stirring, separating the organic phase; the organic phase with saturated sodium chloride solution for washing, drying with anhydrous sodium sulfate, concentrated, isopropyl alcohol recrystallize to get 4 – amino thiazole – 5 – carboxylic acid ethyl ester. The invention also provides a method for removing from a thio group on the aromatic ring of the new method, the raw materials are low cost, high yield, and suitable for production. (by machine translation)
The invention belongs to the technical field of pharmaceutical intermediates, relates to a 4 – amino-thiazole – 5 – carboxylic acid ethyl ester synthesis method, steps which consists in: the 4 – amino – 2 – (methylthio) thiazole – 5 – carboxylic acid ethyl ester dissolved in ethanol, adding concentrated hydrochloric acid, adding zinc powder batches under stirring, reflux reaction for 4 hours, to obtain the neutralizing liquid; to the neutralizing liquid is filtered, the filter cake washing with ethanol for 2 – 3 times, the filtrate concentrated under reduced pressure, to obtain the concentrated solution; adding the concentrated in methylene chloride and water, stirring, separating the organic phase; the organic phase with saturated sodium chloride solution for washing, drying with anhydrous sodium sulfate, concentrated, isopropyl alcohol recrystallize to get 4 – amino thiazole – 5 – carboxylic acid ethyl ester. The invention also provides a method for removing from a thio group on the aromatic ring of the new method, the raw materials are low cost, high yield, and suitable for production. (by machine translation)
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Reference£º
Thiazole | C3H8246NS – PubChem,
Thiazole | chemical compound | Britannica