Category: 15864-32-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.

2. A suspension of 6-bromobenzothiazol-2-ylamine (2. 29 g, 10 mmol) prepared above in sodium hydroxide (40 mL of a 6 M solution, 240 mmol) was refluxed under argon overnight. The reaction mixture was cooled in an ice bath and was acidified to between pH 3 and 5 with conc. HCI. The resulting precipitate was isolated by filtration, washed with water and dried under high vacuum to afford the crude product that was used in the following reaction without further purification., 15864-32-1

As the paragraph descriping shows that 15864-32-1 is playing an increasingly important role.

Reference：
Patent; KINETEK PHARMACEUTICALS, INC.; WO2004/11460; (2004); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Compound 1 (500 mg, 2.18 mmol, 1 eq) and B2Pin2 (665.06 mg, 2.62 mmol, 1.2 eq) in dioxane (8 mL) was added Pd(dppf)Cl2 (159.69 mg, 218.25 mumol, 0.1 eq) and KOAc (321.29 mg, 3.27 mmol, 1.5 eq). The mixture was stirred at 110 C. for 12 hr under N2. The reaction mixture was concentrated under reduced pressure to remove solvent. The residue was diluted with brine 50 mL and extracted with EA 20 mL (20 mL*3). The combined organic layers was filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (SiO2, Petroleum ether:Ethyl acetate=5:1 to 3:1). Compound 2 (907 mg, 1.55 mmol, 71% yield, 47% purity) was obtained as a light yellow solid. 1H NMR (400 MHz, CDCl3) 5=8.06 (s, 1H), 7.77-7.74 (m, 1H), 7.60 (d, J=7.2 Hz, 1H), 4.13 (q, J=7.2 Hz, 2H), 1.28 (s, 12H).

15864-32-1, 15864-32-1 2-Amino-6-bromobenzothiazole 85149, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; 1ST Biotherapeutics, Inc.; LEE, Jinhwa; KIM, Jae Eun; JO, Suyeon; LEE, Gwibin; LIM, Keonseung; PARK, A Yeong; KIM, Misoon; JUNG, Gyooseung; LIM, Seung Mook; LEE, Minwoo; YANG, Heekyoung; KIM, Hyonam; KIM, Hyeongjun; LI, Wanjun; FAN, Mingzhu; (82 pag.)US2019/100500; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 25 mL of 10 M potassium hydroxide solution was added 5 g of 2-amino-6-bromo-benzothiazole,After adding 5 mL of ethylene glycol, the mixture was stirred at 125 C. for 2 h to obtain 2-amino-5-bromobenzenethiol, 15864-32-1

The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; NEUBORON MEDTECH LTD.; LIU, YUAN HAO; CHEN, JUI FEN; HE, JING; (35 pag.)TW2017/22441; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.

Step 3) Formation of6-(4,4,5,delta-tetramethyl-1,3-dioxaborolan-2-yl)-1,3-henzoi.azol-2- amineTo a solution of 6-bromo~1 ,3-benzothiazoi-2~amine (10 g, 43.6 mmoi) in dioxane (50 mL) was added bispinacoiotodiboron (16.6 g, 65.4 mmol), potassium acetate (12.8 g, 130.8 mmol) and PdCI2dppf.DCM (3.55 g, 43.6 mmol) and the resulting mixture was stirred at 100&;C for 12 h. After cooiing to RT the reaction mixture was filtered through a plug of Celite which was further washed with EA. The combined filtrate was evaporated to dryness and the residue purified by column chromatography (PBEA1 85/15) to afford the title compound (5.1 g, 42%) as a white solid. 1H NMR (DMSO-dt, 400 MHz) delta 7.92 (s, 1 H)1 7.65 (bs, 2H)1 7.50 (d, J= 8.7 Hz1 1 H)1 7.29 (d, J = 8.2 Hz,1 H), 1.27 (s, 12H)., 15864-32-1

15864-32-1 2-Amino-6-bromobenzothiazole 85149, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; MERCK SERONO S.A.; SWINNEN, Dominique; JORAND-LEBRUN, Catherine; GRIPPI-VALLOTTON, Tania; GERBER, Patrick; GONZALEZ, Jerome; SHAW, Jeffrey; JEYAPRAKASHNARAYANAN, Seenisamy; WO2010/100144; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: Preparation of n-(6-Bromo-benzothiazol-2-yl)-acetamide A mixture of 6-bromo-benzothiazol-2-ylamine (3.0 g, 13 mmol), Ac2O (1.6 g, 16.5 mmol) and DMAP (2.4 g, 19.5 mmol) in CH2Cl2 (50 mL) was stirred at room temperature for 1 hr. Then the mixture was washed with HCl (2M), saturated Na2CO3, then brine and dried over Na2SO4. The CH2Cl2 phase was evaporated to give n-(6-Bromo-benzothiazol-2-yl)-acetamide (2.5 g, yield 71%) as a white solid., 15864-32-1

15864-32-1 2-Amino-6-bromobenzothiazole 85149, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Heald, Robert; Price, Stephen; Safina, Brian; Savy, Pascal Pierre Alexandre; Seward, Eileen Mary; Sutherlin, Daniel P.; Waszkowycz, Bohdan; US2012/202785; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A compound of Formula P-1 is treated with, for example, potassium thiocyanate and bromine in acetic acid to produce a compound of Formula P-2. The compound of Formula P-2 is treated with an acetylating reagent such as acetyl chloride to produce a compound of Formula P-3. The compound of P-3 is reacted with, for example, bis(pinacolato)diboron (compound P-4) in the presence of a catalyst such as palladium chloride to produce a compound of Formula P-5.

15864-32-1, The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; INTELLIKINE, LLC; LIU, Yi; REN, Pingda; JESSEN, Katayoun; GUO, Xin; ROMMEL, Christian; WILSON, Troy, Edward; WO2014/151147; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Iso-Pentyl nitrite (0.9 mL, 6.8 mmol) and copper (II) chloride (0.938 g, 5.5 mmol) were suspended in CH3CN (25 mL), and the mixture was stirred at 65 C. for 30 min. A solution of 6-bromobenzo[d]thiazol-2-amine (I-2) (1 g, 4.37 mmol) in THF (20 mL) was added dropwise, and the resulting mixture was stirred at 85 C. for 1 h. The mixture was allowed to cool to RT, poured into 20% HCl (200 mL), filtered, and the cake was washed with water (50 mL). The crude product was purified by flash column chromatography on silica gel (200-300 mesh) eluting with petroether/ethyl acetate (40/1) to give the desired product, 6-bromo-2-chlorobenzo[d]thiazole (701) (0.58 g, 53.7% yield) as a pale solid. ESI-MS (M+H)+m/z: 247.9., 15864-32-1

As the paragraph descriping shows that 15864-32-1 is playing an increasingly important role.

Reference：
Patent; Intellikine LLC; Ren, Pingda; Liu, Yi; Wilson, Troy Edward; Li, Liansheng; Chan, Katrina; US2015/225407; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.

Step 1: tert-Butyl 6-bromobenzo[d]thiazol-2-ylcarbamate A mixture of 6-bromobenzo[d]thiazol-2-amine (14.7 g, 64.2 mmol), di-tert-butyl dicarbonate (14.0 g, 64.1 mmol) and N, N-dimethylpyridin-4-amine (40.0 mg, 0.327 mmol) in DCM (200 mL) was stirred at room temperature for 24 h and then filtered. The filtrate was evaporated in vacuo. The resultant residue was purified via flash chromatography on silica gel (solvent gradient: 0-10% ethyl acetate in petroleum ether) to yield 7.26 g (34%) of the title compound as a yellow solid. LCMS (ESI): [M+H]+=329/331., 15864-32-1

15864-32-1 2-Amino-6-bromobenzothiazole 85149, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Genentech, Inc.; Braun, Marie-Gabrielle; Garland, Keira; Hanan, Emily; Purkey, Hans; Staben, Steven T.; Heald, Robert Andrew; Knight, Jamie; Macleod, Calum; Lu, Aijun; Wu, Guosheng; Yeap, Siew Kuen; (183 pag.)US2018/65983; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.

To a solution of commercially available 2-amino-6-bromobenzothiazole (3.0 g, 13.0 mmol) in THF (30 mL) was added acetic anhydride (4 mL, 42.3 mmol). The solution was stirred at room temperature for 2 days. THF was removedin vacuoand the residue was recrystallized from hot EtOAc to giveN-(6-bromobenzo[d]thiazol-2-yl)acetamide (2.5 g, 71%).

15864-32-1, As the paragraph descriping shows that 15864-32-1 is playing an increasingly important role.

Reference：
Article; Pecchi, Sabina; Ni, Zhi-Jie; Han, Wooseok; Smith, Aaron; Lan, Jiong; Burger, Matthew; Merritt, Hanne; Wiesmann, Marion; Chan, John; Kaufman, Susan; Knapp, Mark S.; Janssen, Johanna; Huh, Kay; Voliva, Charles F.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 16; (2013); p. 4652 – 4656;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.

6-bromo-2-aminobenzothiazole (2.50 g, 10.7 mmol)Dissolve DMAP (1.33 g, 12.8 mmol) in 20 mL of dichloromethane.Acetic anhydride (1.23 mL, 13.0 mmol) was added dropwise on an ice bath.After stirring overnight at room temperature, pour in 100 mL of 1N HCl.The resulting solid is suction filtered, the solid is rinsed with water and dried to constant weight.A white solid (2.30 g, 79%) was obtained., 15864-32-1

The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Aikenuo Bio-pharmaceutical Co., Ltd.; He Sudan; Zheng Jiyue; Ma Haikuo; Zhang Xiaohu; (13 pag.)CN107753483; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica