Category: 160844-75-7

Downstream synthetic route of 160844-75-7

The synthetic route of 160844-75-7 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.160844-75-7,Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate,as a common compound, the synthetic route is as follows.

Preparation of febuxostat without isolation of intermediate ethyl-2-(3-cyano-4- isobutoxyphenyl)-4-methyl thiazole-5-carboxylate 3-cyano-4-isobutoxyphenyl boronic acid (5.0 gms/0.02283 moles), ethyl-2-bromo-4-methylthiazole-5-carboxylate (5.70 gms/0.02289 moles) and 50 ml of 2M aqueous sodium carbonate solution were charged in 75 ml toluene, followed by tetrakis (triphenyl phosphine) palladium (1.5 gms). The resultant mixture was stirred at 70- 75¡ãC for 1 hour. The reaction mass was cooled to 25¡ãC and extracted in ethyl acetate (30ml). The organic layer was washed with brine, dried over anhydrous sodium sulphate and the clear filtrate was distilled off completely.The residue was stirred in 40 ml THF under inert atmosphere. To the reaction mass, 2N NaOH (11 ml) was slowly added at 25-30¡ãC and stirred further at reflux for 5 hours. The reaction mass was cooled to 25¡ãC and filtered through celite. The reaction mass was acidified with diluted concentrated HCI. The reaction mass was further stirred for 30 minutes. The resulting solid was isolated by filtration, washed with water until a neutral pH and dried under vacuum to yield 3.3 gms of the titled compound. Efficiency: 72percent, 160844-75-7

The synthetic route of 160844-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CIPLA LIMITED; BIRARI, Dilip, Ramdas; RAO, Dharmaraj, Ramachandra; KANKAN, Rajendra, Narayanrao; CURTIS, Philip, Anthony; WO2011/73617; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Analyzing the synthesis route of 160844-75-7

160844-75-7 Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 9884549, athiazole compound, is more and more widely used in various.

160844-75-7, Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 5:Preparation of febuxostat2-(3-Cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester (100 gm) was dissolved in ethanol (500 ml) at room temperature and then added a solution of sodium hydroxide (13 gm) in water. (250 ml) slowly for 30 minutes. The contents were heated to 65C and maintained for 1 hour. The reaction mass was then cooled to 50C and pH of the reaction mass was adjusted to 2.0 with hydrochloric acid solution (15%). The reaction mass was stirred for 15 minutes at 50C and then cooled to room temperature. The contents were maintained for 3 hours at room temperature and filtered. The solid thus obtained was dissolved in ethanol (500 ml) and then heated to 60C. The reaction mass was treated with carbon at 60C and filtered. The filtrate obtained was then cooled to room temperature and stirred for 2 hours. The reaction mass was further cooled to 10C and maintained for 1 hour. The solid obtained was collected by filtration and washed with chilled ethanol to obtain a wet solid. To the wet solid was added a mixture of ethanol and water (9: 1 ; 500 ml) at room temperature and then heated to 60C to obtain a solution. The solution was stirred for 30 minutes at 60C and then cooled to 25C. The reaction mass was maintained for 1 hour at 25C and the mass was further cooled to 10C. The solid obtained was collected by filtration and dried with vacuum sucking for 15 minutes to obtain 65 gm of febuxostat., 160844-75-7

160844-75-7 Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 9884549, athiazole compound, is more and more widely used in various.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; RAMAKRISHNA REDDY, Matta; VAMSI KRISHNA, Bandi; WO2012/168948; (2012); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Brief introduction of 160844-75-7

160844-75-7 Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 9884549, athiazole compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.160844-75-7,Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate,as a common compound, the synthetic route is as follows.

Example-4 Preparation of Febuxostat Potassium (IA-b) 3.7 N potassium hydroxide solution was added to a reaction mass of (50.0 g) 2-(4-isobutoxy-3-cyanophenyl)-4-methylthiazole-5-ethyl carboxylate in (250.0 ml) isopropyl alcohol. The reaction mixture was stirred and heated to get complete potassium salt of febuxostat. The febuxostat potassium was isolated by filtration. The moisture content of the said compound is 6.03percent. HPLC purity: >99percent The XRPD of potassium salt of febuxostat is attached as .

160844-75-7 Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 9884549, athiazole compound, is more and more widely used in various.

Reference£º
Patent; CADILA HEALTHCARE LIMITED; Dwivedi, Shriprakash Dhar; Prasad, Ashok; Roy, Rushikesh Udaykumar; Patel, Mayur Ramnikbhai; US2013/190366; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica