Category: 161797-99-5

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 161797-99-5, Name is Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, molecular formula is C13H13NO3S. In a Article，once mentioned of 161797-99-5, HPLC of Formula: C13H13NO3S

The peroxisome proliferator activated receptors PPARalpha, PPARgamma, and PPARdelta are ligand-activated transcription factors that play a key role in lipid homeostasis. The fibrates raise circulating levels of high-density lipoprotein cholesterol and lower levels of triglycerides in part through their activity as PPARalpha agonists; however, the low potency and restricted selectivity of the fibrates may limit their efficacy, and it would be desirable to develop more potent and selective PPARalpha agonists. Modification of the selective PPARdelta agonist 1 (GW501516) so as to incorporate the 2-aryl-2-methylpropionic acid group of the fibrates led to a marked shift in potency and selectivity toward PPARalpha agonism. Optimization of the series gave 25a, which shows EC50 = 4 nM on PPARalpha and at least 500-fold selectivity versus PPARgamma and PPARgamma. Compound 25a (GW590735) has been progressed to clinical trials for the treatment of diseases of lipid imbalance.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.HPLC of Formula: C13H13NO3S, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 161797-99-5, in my other articles.

Reference：
Thiazole | C3H7792NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 161797-99-5, An article , which mentions 161797-99-5, molecular formula is C13H13NO3S. The compound – Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate played an important role in people’s production and life.

During the present study, a number of substituted thiazole derivatives have been synthesized by the reaction of 4-hydroxybezene-1-carbothiomide and ethyl-2-chloro acetoacetate to give ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate. The latter reacts with PPA, HMTA and acetic acid to yield ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate. These compounds further react with di-bromo alkane and 4-hydroxy coumarin to give the final thiazole derivatives. These are characterized by elemental analysis, IR and 1H NMR spectra, and have been screened for their antimicrobial activity and found to have significant effect against the tested microorganisms. Some of the synthesized thiazole derivatives are found to exhibit promising activity.

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Reference：
Thiazole | C3H7802NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.161797-99-5, Name is Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, molecular formula is C13H13NO3S. In a Patent，once mentioned of 161797-99-5, Quality Control of: Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Substituted thiazoles

This invention is directed to processes for making substituted thiazoles. The substituted thiazole, ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate, also known as TEI-6720, is useful for treatment of gout and hyperuricemia. This compound belongs to a class of substituted thiazoles that inhibit xanthine oxidase and thus block uric acid production.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Quality Control of: Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, you can also check out more blogs about161797-99-5

Reference：
Thiazole | C3H7787NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 161797-99-5, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 161797-99-5, Name is Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, molecular formula is C13H13NO3S. In a Patent，once mentioned of 161797-99-5

IMPROVED PROCESS FOR THE PREPARATION OF FEBUXOSTAT

An improved and efficient process for the preparation of 2-[3-cyano-4-(2- methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid (febuxostat) that is substantially free from amide by-product is provided.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 161797-99-5 is helpful to your research., Electric Literature of 161797-99-5

Reference：
Thiazole | C3H7806NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 161797-99-5, Name is Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, molecular formula is C13H13NO3S. In a Patent，once mentioned of 161797-99-5, Quality Control of: Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Novel preparation method of febuxostat intermediate (by machine translation)

The invention relates to a preparation method. of non-buxostat intermediate, which comprises: using cheap 4 -hydroxybenzaldehyde as a starting material, to prepare aldoxime, by, rearrangement reaction to prepare the compound Beckmann hydroxyl thiobenzamide 4 – for preparing (152A1 – 00);formyl – 4 4-isobutyloxyphenyl, methyl – 5 5-thiazolidone 4 – in a series of reaction and then reacting, with, halogenated acetoacetate by 2 – (3 – a pot method 2 – in a series of reactions to prepare an intermediate 2 – (4 – of p.hydroxybenzenethibenzoylate) – 4 – in a more easily controlled manner and a different salt form (152A2x); of the starting material (152H1x) to prepare an aldoxymethyl) – 4 – benzenecarboxaldehyde as a starting (152A4 – 00). material. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate. In my other articles, you can also check out more blogs about 161797-99-5

Reference：
Thiazole | C3H7794NS – PubChem,
Thiazole | chemical compound | Britannica

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Biothiols such as cysteine (Cys) and homocysteine (Hcy) are essential biomolecules participating in molecular and physiological processes in an organism. However, their selective detection remains challenging. In this study, ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate (NL) was synthesized as a ratiometric fluorescent probe for the rapid and selective detection of Cys and Hcy over glutathione (GSH) and other amino acids. The fluorescence intensity of the probe in the presence of Cys/Hcy increased about 3-fold at a concentration of 20 equiv. of the probe, compared with that in the absence of these chemicals in aqueous media. The limits of detection of the fluorescent assay were 0.911 muM and 0.828 muM of Cys and Hcy, respectively. 1H-NMR and MS analyses indicated that an excited-state intramolecular proton transfer is the mechanism of fluorescence sensing. This ratiometric probe is structurally simple and highly selective. The results suggest that it has useful applications in analytical chemistry and diagnostics.

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Reference£º
Thiazole | C3H7804NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 161797-99-5, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 161797-99-5, C13H13NO3S. A document type is Patent, introducing its new discovery.

The invention discloses a method for synthesizing thioamide method, comprises the following steps: to fatty nitrile or aromatic as raw materials, with the alkali metal salt or ammonium salt and an amine salt or ammonium salt is vulcanized, for certain solvent in one-step synthesis of thioamide compound, synthesis method of the invention the safety is high, small pollution to the environment, and avoiding the use of expensive raw materials, economy and environmental protection. (by machine translation)

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Reference£º
Thiazole | C3H7797NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 161797-99-5, Name is Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, molecular formula is C13H13NO3S. In a Patent£¬once mentioned of 161797-99-5, Formula: C13H13NO3S

The present invention provides a high-purity 2 – (3 – aldehyde – 4 – isobuoxy phenyl) – 4 – methyl thiazole – 5 – carboxylic acid ethyl ester, cyano phenol, sulfur on behalf of the acetamide as the starting material, merabilite acylation reaction 4 – hydroxy benzamide (II), the reaction product does not separation directly saisai zuo reaction, is separated to obtain 2 – (4 – hydroxy-phenyl) – 4 – methyl – 5 – thiazole carboxylic acid ethyl ester (III); of formula (III) acetate acylation reaction to the compound 2 – (3 – a aldehyde group – 4 – hydroxy-phenyl) – 4 – methyl – 5 – thiazole carboxylic acid ethyl ester (IV), the reaction product does not separation directly isobutyl reaction, formula (I) of 2 – (3 – aldehyde – 4 – isobuoxy phenyl) – 4 – methyl thiazole – 5 – carboxylic acid ethyl ester product, purity ? 99%, content ? 99%. The present invention production process is optimized, thereby greatly improving the quality of the products, and the yield is high. (by machine translation)

The present invention provides a high-purity 2 – (3 – aldehyde – 4 – isobuoxy phenyl) – 4 – methyl thiazole – 5 – carboxylic acid ethyl ester, cyano phenol, sulfur on behalf of the acetamide as the starting material, merabilite acylation reaction 4 – hydroxy benzamide (II), the reaction product does not separation directly saisai zuo reaction, is separated to obtain 2 – (4 – hydroxy-phenyl) – 4 – methyl – 5 – thiazole carboxylic acid ethyl ester (III); of formula (III) acetate acylation reaction to the compound 2 – (3 – a aldehyde group – 4 – hydroxy-phenyl) – 4 – methyl – 5 – thiazole carboxylic acid ethyl ester (IV), the reaction product does not separation directly isobutyl reaction, formula (I) of 2 – (3 – aldehyde – 4 – isobuoxy phenyl) – 4 – methyl thiazole – 5 – carboxylic acid ethyl ester product, purity ? 99%, content ? 99%. The present invention production process is optimized, thereby greatly improving the quality of the products, and the yield is high. (by machine translation)

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Formula: C13H13NO3S, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 161797-99-5, in my other articles.

Reference£º
Thiazole | C3H7790NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 161797-99-5. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 161797-99-5, Name is Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate. In a document type is Patent, introducing its new discovery.

The invention discloses a 2 – (3 – thiophene – 4 – hydroxy-phenyl) – 4 – methyl thiazole – 5 – carboxylic acid ethyl ester. The synthetic method is BuLi as catalyst, 2 – (4 – hydroxy-phenyl) – 4 – methyl thiazole – 5 – carboxylic acid ethyl ester and N, N – dimethyl formamide execute, then reacting with glacial acetic acid to produce 2 – (3 – thiophene – 4 – hydroxy-phenyl) – 4 – methyl thiazole – 5 – carboxylic acid ethyl ester. Synthesis in the reaction process does not adopt the hexamine, during the production of the sensitization factors may, at the same time production method is simple, environmental protection, the product has high purity, high yield, the cost is reduced, and at the same time improving the work efficiency, and is suitable for industrial production. (by machine translation)

The invention discloses a 2 – (3 – thiophene – 4 – hydroxy-phenyl) – 4 – methyl thiazole – 5 – carboxylic acid ethyl ester. The synthetic method is BuLi as catalyst, 2 – (4 – hydroxy-phenyl) – 4 – methyl thiazole – 5 – carboxylic acid ethyl ester and N, N – dimethyl formamide execute, then reacting with glacial acetic acid to produce 2 – (3 – thiophene – 4 – hydroxy-phenyl) – 4 – methyl thiazole – 5 – carboxylic acid ethyl ester. Synthesis in the reaction process does not adopt the hexamine, during the production of the sensitization factors may, at the same time production method is simple, environmental protection, the product has high purity, high yield, the cost is reduced, and at the same time improving the work efficiency, and is suitable for industrial production. (by machine translation)

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Reference£º
Thiazole | C3H7798NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 161797-99-5. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 161797-99-5, Name is Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

A novel process for preparation of ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate is disclosed. The process involves reaction of ethyl 2-(4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate with metal nitrate in presence of acid chloride and N,N-Dimethylformamide to produce title compound with improved yield and economics than that reported in the prior art.

A novel process for preparation of ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate is disclosed. The process involves reaction of ethyl 2-(4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate with metal nitrate in presence of acid chloride and N,N-Dimethylformamide to produce title compound with improved yield and economics than that reported in the prior art.

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Reference£º
Thiazole | C3H7809NS – PubChem,
Thiazole | chemical compound | Britannica