Category: 161798-03-4

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 161798-03-4, Name is Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate, Application In Synthesis of Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate.

The invention relates to a method for synthesizing non- buxostat and an intermediate thereof 2 – (3 – in particular to) – 4 – a method for synthesizing formyl – 4, 4-phenyl: 2 – (3 – methyl-thiazole) – 4 – 5 5- thiazolidone (a) in-DMF isobutoxyphenyl, methyl-thiazole – 5 5-phenyl methyl-thiazole-5-carboxylic acid ethyl, ester in step, and, ethyl acetate extraction DMF 2 – (3 -and method for preparing) – 4 – non-buxostat by, using 2 – (3 – weight crystal) – 4 – The 2 – (3 – product obtained in step is) – 4 – obtained by adding water and ethyl acetate through ethyl acetate extraction of ethyl acetate in a reaction in the presence of potassium carbonate and ethyl bromo-isobutane. in a process of Step No.No. STR7No.No.No. STR7. No.No.. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate. In my other articles, you can also check out more blogs about 161798-03-4

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Thiazole | C3H7764NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 161798-03-4, Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.161798-03-4, Name is Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate, molecular formula is C18H21NO4S. In a patent, introducing its new discovery.

A febuxostat which purity is not less than 99.0%, method for preparation thereof, and pharmaceutical composition thereof. The method for preparation includes recrystallizing febuxostat in a mixed solvent. The said pharmaceutical composition can be used in manufacture of medicaments for treating diseases associated with hyperuricemia.

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Thiazole | C3H7775NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 161798-03-4, Name is Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate, molecular formula is C18H21NO4S. In a Article，once mentioned of 161798-03-4, Computed Properties of C18H21NO4S

A novel approach to convert aldehydes into nitriles using NH3·H2O/FeCl2/NaI/Na2S2O8 has been developed. Both alkyl and aryl nitriles were obtained in good to excellent yields. Electron-withdrawing and electron-donating groups, such as fluoro, chloro, bromo, nitro, ester, cyano, trifluoromethyl and alkoxy were tolerated. Notably, febuxostat and its intermediate, ethyl 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylate, were obtained in excellent yields.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Computed Properties of C18H21NO4S, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 161798-03-4, in my other articles.

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Thiazole | C3H7774NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.161798-03-4, Name is Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate, molecular formula is C18H21NO4S. In a Patent，once mentioned of 161798-03-4, Quality Control of: Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

2 – (3 – aldehyde – 4 – isobuoxy phenyl) – 4 – methyl thiazole – 5 – carboxylic acid ethyl ester (by machine translation)

The present invention provides a high-purity 2 – (3 – aldehyde – 4 – isobuoxy phenyl) – 4 – methyl thiazole – 5 – carboxylic acid ethyl ester, cyano phenol, sulfur on behalf of the acetamide as the starting material, merabilite acylation reaction 4 – hydroxy benzamide (II), the reaction product does not separation directly saisai zuo reaction, is separated to obtain 2 – (4 – hydroxy-phenyl) – 4 – methyl – 5 – thiazole carboxylic acid ethyl ester (III); of formula (III) acetate acylation reaction to the compound 2 – (3 – a aldehyde group – 4 – hydroxy-phenyl) – 4 – methyl – 5 – thiazole carboxylic acid ethyl ester (IV), the reaction product does not separation directly isobutyl reaction, formula (I) of 2 – (3 – aldehyde – 4 – isobuoxy phenyl) – 4 – methyl thiazole – 5 – carboxylic acid ethyl ester product, purity ? 99%, content ? 99%. The present invention production process is optimized, thereby greatly improving the quality of the products, and the yield is high. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Quality Control of: Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate, you can also check out more blogs about161798-03-4

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Thiazole | C3H7760NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 161798-03-4, Name is Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate, molecular formula is C18H21NO4S. In a Article£¬once mentioned of 161798-03-4, Formula: C18H21NO4S

The title compound, 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid ethanol monosolvate, C16H16N2O3S¡¤C2H6O, (I), displays intermolecular O-H.. O and O-H.. N bonds in which the carboxyl group of the febuxostat molecule and the hydroxyl group of the ethanol molecule serve as hydrogen-bond donor sites. These interactions result in a helical hydrogen-bonded chain structure. The title structure is isostructural with a previously reported methanol analogue.

The title compound, 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid ethanol monosolvate, C16H16N2O3S¡¤C2H6O, (I), displays intermolecular O-H.. O and O-H.. N bonds in which the carboxyl group of the febuxostat molecule and the hydroxyl group of the ethanol molecule serve as hydrogen-bond donor sites. These interactions result in a helical hydrogen-bonded chain structure. The title structure is isostructural with a previously reported methanol analogue.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Formula: C18H21NO4S, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 161798-03-4, in my other articles.

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Thiazole | C3H7754NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 161798-03-4. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 161798-03-4, Name is Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of febuxostat intermediate I, a preparation method of the febuxostat intermediate II, application of the febuxostat intermediate II and a preparation method of the febuxostat intermediate II. The preparation method of the febuxostat product comprises the following steps: preparing febuxostat intermediate I and febuxostat intermediate II; directly adding water and organic alkali hydrolysis reaction in the non-febuxostat intermediate II solution 6.0 – 7.0. The non-febuxostat finished product is high in product purity, high in product purity, high in preparation method yield and low in cost; solid-liquid separation is easily realized; the residual solvent is easily removed in a finished product preparation step. (by machine translation)

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of febuxostat intermediate I, a preparation method of the febuxostat intermediate II, application of the febuxostat intermediate II and a preparation method of the febuxostat intermediate II. The preparation method of the febuxostat product comprises the following steps: preparing febuxostat intermediate I and febuxostat intermediate II; directly adding water and organic alkali hydrolysis reaction in the non-febuxostat intermediate II solution 6.0 – 7.0. The non-febuxostat finished product is high in product purity, high in product purity, high in preparation method yield and low in cost; solid-liquid separation is easily realized; the residual solvent is easily removed in a finished product preparation step. (by machine translation)

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Thiazole | C3H7769NS – PubChem,
Thiazole | chemical compound | Britannica

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 161798-03-4, Name is Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate, molecular formula is C18H21NO4S. In a Patent, authors is KOFTIS, Theocharis, V.£¬once mentioned of 161798-03-4, 161798-03-4

The present invention relates to a novel preparation method for 2-(3-cyano-4-isobutoxyphenyl)- 4-methyl-1,3-thiazole-5-carboxylic acid (Febuxostat) via novel and high yielded conversion of a formyl group in to a cyano group.

The present invention relates to a novel preparation method for 2-(3-cyano-4-isobutoxyphenyl)- 4-methyl-1,3-thiazole-5-carboxylic acid (Febuxostat) via novel and high yielded conversion of a formyl group in to a cyano group.

161798-03-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 161798-03-4

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Thiazole | C3H7758NS – PubChem,
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-03-4,Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

172.8 g of formic acid and16.0 g of ethyl 2-(3-formyl-4-isobutoxy-phenyl)-4-methyl-thiazole-5-carboxylate (FBT-1) prepared in Example 1 were added to a 500 ml round bottom flask, 4.2g hydroxylamine hydrochloride and 4.1g sodium formate were added, and stirred at 105 ~ 110 C for 2h. After completion of the reaction, cooled to 20 ~ 30 C, heat crystallization was carried out for 1h, filtered, filter cake was washed with 25.3g ethanol, filtered, dried and 14.2 g of ethyl 2-(3-cyano-4-isobutoxy-phenyl)-4-methyl-thiazole-5-carboxylate (FBT-2) was obtained in a yield of 89.5%., 161798-03-4

The synthetic route of 161798-03-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hunan Fangsheng Pharmaceutical Co., Ltd.; Zhang Qinghua; Chen Bo; Yan Zhiyong; (6 pag.)CN109912531; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-03-4,Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

161798-03-4, Example 3Preparation of 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazole carboxylic acid (FBZC)To a 500 ml three-necked bottle was added 28.0 g of ethyl 2-[3-formyl-4-(2-methyl propoxy)phenyl]-4-methyl-5-thiazolcarboxylate, 280 ml of 10% sodium hydroxide solution and 90 ml of ethanol, the reaction was performed under stirring at about 80 C. for about 4 h, then the reaction stopped, cooled, adjusted by adding dropwise slowly a concentrated hydrochloride to about pH 3. A white solid was precipitated and filtered. The filter cake was washed with water, and dried by vacuum sucking. The filter cake was recrystallized with ethyl acetate, filtered, then dried at 70-75 C. in a reduced pressure (-0.080 to -0.085 MPa) to obtain 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazole carboxylic acid (FBZC) (11.2 g) as a white crystalline. Purity (by HPLC): 99%. IR (KBr): 3432, 2966, 2871, 1679, 1652, 1605, 1513, 1447, 1427, 1371, 1179, 1111, 1014 cm-1. 1H-NMR (500 MHz, DMSO-d6) delta (ppm): 13.360 (1H, s), 10.397 (1H, s), 8.191-8.153 (2H, m), 7.337-7.319 (1H, d), 3.990-3.977 (2H, d), 2.659 (3H, s), 2.163-2.084 (1H, s), 1.045-1.031 (6H, d).

161798-03-4 Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 10904158, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO/. LTD.; US2011/282069; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-03-4,Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

To the solution of ethyl 2-[3-formyl-4-(2-methylpropoxy) phenyl]-4- methylthiazole-5-carboxylate compound of formula-12 (10 gms) in formic acid (40 ml) was added hydroxylamine hydrochloride (2.38 gms) and sodium formate (2.35 gms).Stirred the reaction mixture for 10 minutes. Heated the reaction mixture to 100C and stirred for four hours at same temperature. Cooled the reaction mixture to 25 C and quenched with water. Stirred the reaction mixture for 10 hours, filtered the precipitated solid and washed with water. Dried the material to get the title compound. Yield: 10 gms. Take the dry material, added 30 ml of ethyl acetate and heated to reflux temperature. Stirred the reaction mixture for 30 minutes at reflux temperature. Cooled the reaction mixture to 25C and filtered the precipitated solid. Dry the material to get the title compound as a pure material. Yield: 8.5 gms.

161798-03-4, As the paragraph descriping shows that 161798-03-4 is playing an increasingly important role.

Reference£º
Patent; MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; VENKATA PANAKALA RAO, Gogulapati; PRASAD, Gadamsetty; WO2011/141933; (2011); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica