03/9/2021 News Discovery of 5-(2-Hydroxyethyl)-3,4-dimethylthiazol-3-ium iodide

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(Chemical Equation Presented). A facile synthesis of highly functionalized 3-aminofuran derivatives by the multicomponent reactions of thiazolium salts, aldehydes, and DMAD is described.

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Reference:
Thiazole | C3H5961NS – PubChem,
Thiazole | chemical compound | Britannica

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A series of new lipid-like thiazole derivatives have been synthesized in good yields by O-alkylation of 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole, a thiamine metabolite, under phase transfer catalysis conditions followed by N-alkylation with the aim to obtain potential anticancer and antimicrobial agents. The synthesized cationic amphiphiles and their ether precursors were subjected to in vitro cytotoxic evaluation against monolayer human fibrosarcoma HT-1080 and mouse hepatoma MG-22A tumour cell lines and normal mouse NIH 3T3 fibroblasts and were screened for antimicrobial activity concerning gram-positive and gram-negative bacterial and fungal strains. The synthesized compounds possessed strong antimicrobial activity, significant selective cytotoxicity and high NO-induction ability. In vivo investigation of 3,4-dimethyl-5-(2-undecyloxyethyl)-1,3-thiazol-3-ium iodide confirmed anticancer action, reliably inhibiting mouse sarcoma S-180 tumour growth.

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Reference:
Thiazole | C3H5952NS – PubChem,
Thiazole | chemical compound | Britannica

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A detailed study of the fluorescence and phosphorescence characteristics of thiamine (Vitamin B1), thiamine pyrophosphate (cocarboxylase), and a number of related compounds has been undertaken.The attempt to enhance the phosphorescence of thiamine by several external heavy-atom species resulted in a new emission band, which has been assigned to a charge-transfer state.

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Thiazole | C3H5958NS – PubChem,
Thiazole | chemical compound | Britannica

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An efficient coupling reaction of allyl acetate with (O-azaaryl) carboxaldehyde by Pd-NHC dual catalysis has been developed. This reaction proceeds via direct coordination between the ortho nitrogen atom in the heterocycle and Pd(0). This dual catalysis is achieved under mild conditions to give 1,4-diones as products with up to 90% yield. This journal is the Partner Organisations 2014.

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Reference:
Thiazole | C3H5949NS – PubChem,
Thiazole | chemical compound | Britannica

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The invention relates to a method of removing 3-deoxyglucosone and other alpha-dicarbonyl sugars from skin. The invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin. The invention also relates to methods of treating 3-deoxyglucosone and other alpha-dicarbonyl sugars associated diseases and disorders of skin.

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Reference:
Thiazole | C3H5940NS – PubChem,
Thiazole | chemical compound | Britannica

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A novel thiazolium with a sulfonate charge tag was synthesized to test the feasibility of tracking the progress of a thiazolylidene-catalyzed benzoin condensation reaction using electrospray ionization-mass spectrometry (ESI?MS). Intermediates in the benzoin condensation were ?fished? out of a reaction mixture and detected using MS. Tandem MS and calculations were used to support structural assignments. The results are consistent with the Breslow mechanism. These data show the viability of synthesizing negatively charged compounds that will both catalyze and track reactions involving N-heterocyclic carbene organocatalysis, which are becoming increasingly prevalent in organic synthesis.

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Reference:
Thiazole | C3H5955NS – PubChem,
Thiazole | chemical compound | Britannica

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The present invention relates to compounds of the formula I, or an isomer, a pharmaceutically acceptable salt and solvates; the invention also relates to the general formula I compound or its isomer, pharmaceutically acceptable salt and solvates, and a pharmaceutically acceptable carrier, excipient or diluent composition; the invention also relates to the compounds of the formula I, or an isomer, a pharmaceutically acceptable salt and solvates, for with glutamate hypofunction of the disorders, neurodegenerative diseases, respiratory diseases or conditions of use of the; in particular for the AMPA receptor with symptoms of the disease or in use. (by machine translation)

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Reference:
Thiazole | C3H5933NS – PubChem,
Thiazole | chemical compound | Britannica

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The mild reaction conditions of the palladium-copper coupling-isomerization reaction open a highly convergent, chromogenic route to blue emissive pyrroles in the sense of a consecutive four-component reaction. By virtue of this strategy a phenol derivative can be readily accessed, which can be transformed in a level-2 transformation to a library of bichromophoric pyrrol-fluorophore conjugates by facile alkylation with fluorophore halides. The photophysics of the underlying blue emitter derivative and the conjugates is studied by absorption and emission spectroscopy, furnishing intramolecular energy transfer at short distances as well as competing fluorescence quenching. In some cases partial energy transfer results in the occurrence of dual emission, for instance seen as magenta-rose emission arising from blue and red orange luminescence. The experimental photophysical studies are rationalized by DFT and TD-DFT calculations.

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Reference£º
Thiazole | C3H5938NS – PubChem,
Thiazole | chemical compound | Britannica

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A study was made of the PMR spectra in CDCl3 of thiazolium iodides and chlorides that are not substituted in the 2 position of the thiazolium ring.Solvation of the thiazolium salts with methanol causes changes in the chemical shifts and from of the signals of the proton on C2.An upfield shift of the proton on C2 in 3-benzyl-4-methylthiazolium chloride is observed in presence of 0.5 equivalent or more of methanol relative to the molar concentration of the thiazolium salt.The chemical shifts of the C2 protons of 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride and 3-benzyl-4-methylthiazolium iodide change to a smaller degree.It is supposed that the mechanisms of the solvation of the thiazolium ion include donor-acceptor interaction between the unshared electron pair of the oxygen atom of the solvating agent and the sulfur atom of the thiazolium ring.A discussion is given of possible mechanisms of the solvation of the thiazolium ion in the enzymic transformations of thiamine diphosphate.

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Thiazole | C3H5951NS – PubChem,
Thiazole | chemical compound | Britannica

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The present invention relates to an improved process for the preparation of pyrroles derivatives having hypolipidemic and hypocholesteremic activities. In particular, the invention relates to an improved process for the preparation of 2- ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy) phenyl)propanoate and its pharmaceutically acceptable salts, hydrates, solvates, polymorphs or intermediates thereof. The invention also relates to an improved process for the preparation of mesylate compound (A1).

The present invention relates to an improved process for the preparation of pyrroles derivatives having hypolipidemic and hypocholesteremic activities. In particular, the invention relates to an improved process for the preparation of 2- ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy) phenyl)propanoate and its pharmaceutically acceptable salts, hydrates, solvates, polymorphs or intermediates thereof. The invention also relates to an improved process for the preparation of mesylate compound (A1).

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Thiazole | C3H5936NS – PubChem,
Thiazole | chemical compound | Britannica