Category: 16629-15-5

16629-15-5, 2-Bromo-5-chlorothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-bromo-5-chlorothiazole (0.068 g, 0.34 mmol, 1.0 eq) in 1,4-dioxane (2.0 mL) was added compound 199.3 (0.10 g, 0.41mmol, 1.2eq) followed by addition of 1M aq. Na2C03 (0.68 mL, 0.68 mmol, 2.0 eq). Reaction mixture was degassed with argon for 10 min and Pd(PPh3)4 (0.037g, 0.034mmol, O. leq) was added. Reaction mixture was stirred at 100 C for 16 h. After completion of reaction was quenched with water and extracted with EtOAc. Organic layers were combined, washed with brine, dried over Na2S04 and concentrated under reduced pressure to obtain crude material. The crude was purified by column chromatography to furnish 1.4. (0.025 g, 23.0 %). MS(ES): m/z 314.4 [M]+

16629-15-5, The synthetic route of 16629-15-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NIMBUS LAKSHMI, INC.; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine C.; LEIT DE MORADEI, Silvana Marcel; MASSE, Craig E.; MCLEAN, Thomas H.; MONDAL, Sayan; (401 pag.)WO2018/71794; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

16629-15-5, 2-Bromo-5-chlorothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of Intermediate 2 (30.1 g, 50% purity, 54.2 mmo[), 2-bromo-5-ch[oro-1 ,3-thiazo[e (14.0 g, 70.4 mmo[), [1,1, -Bis-(dipheny[phosphino)-ferrocen]pa[[adium(II) dich[oride (6.63 g, 8.13 mmo[), and K2C03 (65 mL, 2.OM, 130 mmo[)in THF (890 mL) was stirred at ref[ux unti[ comp[ete conversion. The so[vent was evaporated under reduced pressure, water added and the mixture extracted with EtOAc. The combined organic [ayers were washed with saturated aqueous NaC[so[ution and evaporated to dryness under reduced pressure. Crude materia[ was purified by co[umn chromatography (si[ica ge[, hexane / EtOAc gradient) to give5.21 g (34% yie[d) of the tit[e compound.1H NMR (400 MHz, DMSO-d6): oe [ppm] 3.85 – 3.90 (m, 3 H) 7.44 (dd, 1 H) 7.51 (dd, 1 H) 7.84 (t, 1 H) 7.99 (5, 1 H) 10.35 (br. s., 1 H).

16629-15-5, 16629-15-5 2-Bromo-5-chlorothiazole 18519960, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; EVOTEC AG; DAVENPORT, Adam James; BRAEUER, Nico; FISCHER, Oliver Martin; ROTGERI, Andrea; ROTTMANN, Antje; NEAGOE, Ioana; NAGEL, Jens; GODINHO-COELHO, Anne-Marie; (703 pag.)WO2016/91776; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica