Category: 170961-15-6

170961-15-6, tert-Butyl thiazol-2-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1; a) 2-(Tert-butoxycarbonylamino)-5-fluorothiazole; 2-(Tert-butoxycarbonylamino)thiazole (lOg, 0.050mol) in THF (0.2L) was cooled to -50C under argon. tBuLi solution in pentane (60mL of a 1.7M solution, 0.102mol, 2.05eq) was added over a period of 30min and the temperature kept below -40C. The suspension thus obtained was stirred at -50C for 30min. A solution of N-fluorobenzenesulfonimide (NFSi) was prepared (22. Og, 0.07mol in 70mL THF, 1.4eq) and 50mL of this solution (leq) was added over a 5min period and the temperature kept under -40C. The reaction was stirred for 20min at -50C. Then tBuLi (lOmL, 0.017mol, 0.35eq) and the NFSi solution (lOmL, 0.4eq) added. The solution thus obtained was stirred at -50C for 45min and then added to saturated NH4CI solution (300mL). The organic phase was separated and the aqueous phase further washed with diethylether (lOOmL). The combined organic fractions were washed with brine (20mL) solution and dried (Na2SO?}). The solvent was removed and the solid further dried to afford a brown solid. To this crude product was added trifluoroethanol (60mL) and formic acid (0.6mL). The suspension was heated to 85C until it gave a solution. The flask was then cooled to RT and the precipitate thus formed filtered off to afford, after drying under high vacuum, the title compound (6.4g, contains 2.3% of starting material according to HPLC at275nm). After a second crystallisation (trifluoroethanol (22mL) and formic acid (0.22mL),for 20min at 85C), the title compound was obtained as an off white solid (4.6g, contains 1% of starting material, 97.5% pure by HPLC). ‘HNMR (CDC13) 8: 6.90 (1H, d, CHCF), 1.60 (9H, s, Boc-H)., 170961-15-6

As the paragraph descriping shows that 170961-15-6 is playing an increasingly important role.

Reference£º
Patent; PROSIDION LIMITED; WO2006/16174; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

170961-15-6, tert-Butyl thiazol-2-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To tetrahydrofuran solution (100 ml) of 47 (10.0 g, 49.9 mmol), t-butoxy potassium (6.72 g, 59.9 mmol) was added at 0C while stirring, stirred for 10 min at the same temperature, added iodomethane (4.66 ml, 74.9 mmol), and stirred for 16 hours at room temperature. The insolubles were removed by filtering the reaction mixture, and the filtrate was evaporated to dryness under reduced pressure. The residue was purified by silica gel column chromatography (solvent: n-hexane/ethyl acetate = 9/1), to obtain 48 (6.53 g, 61%) of colorless solid substance. mp 51?52 C, 1H NMR(500MHz, DMSO-D6)delta 1.53(9H,s),3.47(3H,s),7.25(1H,d,J=3.5Hz),7.45(1H,d,J=3.5Hz) ,IR(Neat)1734cm-1, APCI-MS m/z 215[M+H]+, 170961-15-6

The synthetic route of 170961-15-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Tohoku University; EP2103611; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

170961-15-6, tert-Butyl thiazol-2-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: n-BuLi (2.5M in THF, 1.4equiv) was added drop wise to a mixture of compound 1a or 1b (1equiv) and aldehyde (1.2equiv) in THF (?20mL) at -78C for 2h. The reaction was quenched by adding a saturated aqueous solution of NH4Cl, extracted with EtOAc, washed with water and then brine. The organic phase was dried over anhydrous Na2SO4, evaporated, and the residue was purified by silica gel column chromatography

170961-15-6, As the paragraph descriping shows that 170961-15-6 is playing an increasingly important role.

Reference£º
Article; Khalil, Ahmed; Edwards, Jessica A.; Rappleye, Chad A.; Tjarks, Werner; Bioorganic and Medicinal Chemistry; vol. 23; 3; (2015); p. 532 – 547;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica