Category: 1747-60-0

Downstream synthetic route of 1747-60-0

1747-60-0, The synthetic route of 1747-60-0 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1747-60-0,2-Amino-6-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

To a black solution of Copper (II) bromide (149 mg, 0.666 mmol) in Acetonitrile(1 mL) was added t-Butyl nitrite (0.095 mL, 0.72 1 mmol) at room temperature followedby 6-methoxybenzo[d]thiazol-2-amine (100mg, 0.555 mmol). Immediate bubbling and amild exotherm was observed upon benzothiazole addition. After 3 hours, the reactionmixture was diluted with EtOAc and washed with 1.0 M HC1, saturated NaHCO3, andthen Brine. The organic phase was dried over Mg504, filtered and concentrated to areddish-brown solid. The crude material was purified by ISCO flash chromatography (0-15% EtOAc/Hex over 20 mm, 12 g silica gel cartridge, Product at 5%). The desiredfractions were combined and concentrated to yield Intermediate 253A (84 mg, 0.344mmol, 62.0 % yield) as an off-white solid. LC-MS. Method H, RT = 1.12 mm, MS (ESI)m/z: 244.0, 246.0 (M+H). ?H NMR (400MHz, CHLOROFORM-d) 7.89 (d, J9.0 Hz,1H), 7.28 (1H under CDC13), 7.09 (dd, J9.0, 2.6 Hz, 1H), 3.90 (s, 3H)

1747-60-0, The synthetic route of 1747-60-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; BATES, J. Alex; HALPERN, Oz Scott; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (1137 pag.)WO2018/13774; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Simple exploration of 1747-60-0

1747-60-0, As the paragraph descriping shows that 1747-60-0 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1747-60-0,2-Amino-6-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

The starting material 2-bromo-6-methoxy-benzothiazole is prepared by using a PEG- assisted Sandmeyer reaction of the commercially available 2-amino-6-methoxy- benzothiazole according to a literature procedure (N. Suzuki et al., Chemistry Express 1992, 7, 717).

1747-60-0, As the paragraph descriping shows that 1747-60-0 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; WO2008/89933; (2008); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica