Category: 1759-28-0

In an article, published in an article,authors is Arisawa, Mieko, once mentioned the application of 1759-28-0, Name is 4-Methyl-5-vinylthiazole,molecular formula is C6H7NS, is a conventional compound. this article was the specific content is as follows.1759-28-0

RhH(PPh3)4 and 1,3-bis(dicyclohexyl)phosphinopropane (dcypp) catalyze the 2-methylthiolation of oxazoles and thiazoles using 2-(methylthio)thiazole as a thiolating reagent. The methylthio transfer reaction is under equilibrium, and various 2-methylthiolated thiazoles and oxazoles were obtained in moderate to good yields by removing thiazole under refluxing o-dichlorobenzene.

RhH(PPh3)4 and 1,3-bis(dicyclohexyl)phosphinopropane (dcypp) catalyze the 2-methylthiolation of oxazoles and thiazoles using 2-(methylthio)thiazole as a thiolating reagent. The methylthio transfer reaction is under equilibrium, and various 2-methylthiolated thiazoles and oxazoles were obtained in moderate to good yields by removing thiazole under refluxing o-dichlorobenzene.

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Reference£º
Thiazole | C3H5636NS – PubChem,
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1759-28-0,4-Methyl-5-vinylthiazole,as a common compound, the synthetic route is as follows.

At room temperature, (Rs) imine 2 (0.3 mmol) and the additive (0.315 mmol) was dissolved in 3 mL THF with vigorous stirring for about half an hour. The resulted clear solution was added to the priorly prepared benzothiazol-2-yl metallic reagent (0.45 mmol in 3 mL THF) at -78 C. The reaction was accomplished rapidly within 10 min (monitored by TLC). Then the reaction was quenched with aqueous saturated NH4Cl, extracted with DCM (10 mL ¡Á 3), washed by brine (10 mL), dried over Na2SO4, and concentrated under vacuum. The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate 3:1-1:1). The diastereoselectivity was determined by 1H NMR analysis of the crude product., 1759-28-0

The synthetic route of 1759-28-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Jinlong; Yang, Yuhong; Wang, Mei; Lin, Li; Wang, Rui; Tetrahedron Letters; vol. 53; 51; (2012); p. 6893 – 6896;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica