Category: 182692-69-9

Reference of 182692-69-9, An article , which mentions 182692-69-9, molecular formula is C3HBrN2O2S. The compound – 5-Bromo-2-nitrothiazole played an important role in people’s production and life.

High-throughput screening with cyclin-dependent kinase 5 (cdk5)/p25 led to the discovery of N-(5-isopropyl-thiazol-2-yl)isobutyramide (1). This compound is an equipotent inhibitor of cdk5 and cyclin-dependent kinase 2 (cdk2)/cyclin E (IC50 = ca. 320 nM). Parallel and directed synthesis techniques were utilized to explore the SAR of this series. Up to 60-fold improvements in potency at cdk5 and 12-fold selectivity over cdk2 were achieved.

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Reference：
Thiazole | C3H6067NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 182692-69-9, Name is 5-Bromo-2-nitrothiazole, molecular formula is C3HBrN2O2S. In a Article，once mentioned of 182692-69-9, Recommanded Product: 182692-69-9

While reaction of 2-bromo-5-nitrothiazole (2) with weakly basic secondary aliphatic amines gives the expected 2-amino products from nucleophilic displacement of the bromine, reaction of the isomeric 5-bromo-2-nitrothiazole (3) with such amines gives mixtures of the expected 5-amino products together with 2-aminated 5-nitrothiazole rearrangement products. The identity of the latter were detemined by alternative synthesis, and by X-ray crystallographic determination of a derivative. The mechanism proposed is a slow thermal isomerization of 5-bromo-2-nitrothiazole (3) to the much more reactive 2-bromo-5-nitro isomer 2 which competes, in the case of relatively weak amine nucleophiles, with the direct (but slow) nucleophilic displacement of the 5-bromo group to form the normal displacement products.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: 182692-69-9. In my other articles, you can also check out more blogs about 182692-69-9

Reference：
Thiazole | C3H6066NS – PubChem,
Thiazole | chemical compound | Britannica