Category: 1843-21-6

β-Anilinovinyl derivatives of heterocyclic bases. III. Synthesis and absorption spectra of new anilinovinyl derivatives was written by van Dormael, A. E.;Nys, J.. And the article was included in Bulletin des Societes Chimiques Belges in 1952.Synthetic Route of C13H10N2S This article mentions the following:

Compounds of type I were prepared by refluxing 0.01 mole I (R = H, X = I) with 0.02 mole of the aniline with the desired substituent 10 min. in 25 ml. EtOH, adding 15 ml. concentrated HCl, and refluxing a further 2 hrs.; cooling, dilution with 75 ml. H₂O, filtering, and recrystallizing from alc. gave the following desired I [X^–, R, m.p. (crystallization solvent), λ_maximum (mμ), and log ε given]: I^–, CO₂H, 26-2° (EtOH), 423, 4.93; I^–, CO₂Et, 236-7° (EtOH), 425, 4.92; I^–, Ac, 220-1° (aqueous EtOH), 429, 4.80; Cl^–, NO₂, 200-1° (PrOH), 442, 4.56. The I were considered to be analogous to the monomethine cyanine (II) of the ethiodide of benzothiazole (C.A. 36, 467.1) and to the substituted anils (III) of PhNHCH:CHCHO. Since the III series could not be made, a number of the dianils (IV) of glutaconaldehyde, [R’C₆H₄NHCH:CHCH:CHCH:NHC₆H₄R’-p]⁺X^–, were prepared, the first 4 by the method of Zincke [via 1-(2,4-dinitrophenyl)pyridinium salts and ArNH₂], the last 3 by the method of König (via 1-cyanopyridinium bromide and ArNH₂) [R’, X, m.p., λ_maximum (mμ) given]: H, Cl, 165-7° (from Me₂CO by concentrated HCl, with repeated recrystallizations giving a lower m.p.), 485; Cl, Cl, 143° (MeOH), 494; MeO, Cl, 168-70° (3 EtOH crystallizations gave m. 127-9°), 509; Me₂N, Cl, 164-6°, 548; CO₂H, Cl, 177-9°, 498; CO₂Et, Br, 175-8°, 506; Ac, Br, 174-6°, 513; NO₂, Br, 149-50°, 524. λ_maximum for III were calculated on the assumption that they were 102.5 mμ less than for IV (C.A. 36, 467.1; 43, 1653⁺). An average of λ_maximum for II (423 mμ) and for III (calculated) was compared with λ_maximum for I exptl., with good agreement (neg. deviation contrary to expectation); results compared with similar ones for unsym. substituted trimethinic cyanines (C.A. 40, 5922.7). In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Synthetic Route of C13H10N2S).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Synthetic Route of C13H10N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Copper-catalyzed synthesis of 2-aminobenzothiazoles from carbodiimide and sodium hydrosulfide was written by Zeng, Weilan;Dang, Pan;Zhang, Xiaoyun;Liang, Yun;Peng, Caiyun. And the article was included in RSC Advances in 2014.Recommanded Product: 1843-21-6 This article mentions the following:

An efficient copper-catalyzed method for the synthesis of a variety of 2-aminobenzothiazoles was developed. The reaction proceeded from carbodiimide and sodium hydrosulfide via a tandem reaction in the presence of copper(II) trifluoromethanesulfonate affording the corresponding 2-aminobenzothiazole derivatives in good to perfect yields. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Recommanded Product: 1843-21-6).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Recommanded Product: 1843-21-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Heteroaromatic N-oxide. X. Synthesis and reactions of benzothiazole 3-oxide was written by Takahashi, Shiro;Hashimoto, Shinichiro;Kano, Hideo. And the article was included in Chemical & Pharmaceutical Bulletin in 1970.Name: N-Phenylbenzo[d]thiazol-2-amine This article mentions the following:

Benzothiazole 3-oxide (I) was synthesized from its 2-Me derivative, via the corresponding aldoxime, carbonitrile, imido ester and carboxylic acid. The reactions of I: deoxygenation, reactions with various nucleophilic agents (tosyl chloride, Ac2O, PhMgBr, NaHSO3, N2H4.H2O and KCN-BzCl) involving some 1,3-dipolarophiles (benzyne, PhNCO and tetracyanoethylene), and quaternizations were investigated and compared with those of the corresponding imidazole N-oxide. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Name: N-Phenylbenzo[d]thiazol-2-amine).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Name: N-Phenylbenzo[d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Reactions of new nitroethane derivatives; formation of new 1,5-benzothiazepines and benzothiazoles III was written by Bercin, Erdogan;Uysal-Gokce, Mehtap;Noyanalpan, Ningur. And the article was included in Journal of Faculty of Pharmacy of Gazi University in 1996.SDS of cas: 1843-21-6 This article mentions the following:

The reactions of [(aminophenyl)thio]phenylnitroethane derivatives, 2-NH₂C₆H₄SCH(CH₂NO₂)C₆H₄R (2; R = H, Me) with isothiocyanates and benzaldehydes were studied. The reaction of 2 with isothiocyanates, R¹NCS (R¹ = Ph, 4-ClC₆H₄) gave 2-anilinobenzothiazoles I. Depending on the reaction temperature, 2 reacted with benzaldehydes (4-R¹C₆H₄CHO, R¹ = H, Cl, OMe, OEt) to give either 2-phenylbenzothiazole derivative II or 1,5-benzothiazepines III (R = H, Me, R¹ = H). In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6SDS of cas: 1843-21-6).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.SDS of cas: 1843-21-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Reaction between o-aminothiophenol and aryl isothiocyanates. II. The influence of the reactant ratio was written by Nicolaescu, Tatiana;Arventiev, Boris. And the article was included in Buletinul Institutului Politehnic din Iasi, Sectia 2: Chimie in 1978.Category: thiazole This article mentions the following:

The reaction of o-H₂NC₆H₄SH with RNCS (R = Ph, m-tolyl) (1:2 molar ratio) gave mixtures of benzothiazoyl I (same R) and RNHC(S)NHR (same R). In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Category: thiazole).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Complexation of copper(II), cobalt(II), nickel(II) and chromium(III) with 2-hydroxy-, 2-hydrazo- and 2-phenylaminobenzothiazole in water-ethanol solutions was written by Manolov, S.;Davarski, K.;Auatai, I.. And the article was included in Koordinatsionnaya Khimiya in 1987.Safety of N-Phenylbenzo[d]thiazol-2-amine This article mentions the following:

Ligand acid dissociation and metal complexation constants were determined pH-metrically at 293 K in flowing N atm. Stability constants (log β) for 1:1 and 1:2 metal:ligand complexes decrease in the order Cr (III) > Cu(II) > Ni(II) ∼ Co(II). In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Safety of N-Phenylbenzo[d]thiazol-2-amine).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Safety of N-Phenylbenzo[d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Action of chlorine on aryl thiocarbimides and the reactions of aryl isocyanodichlorides was written by Dyson, G. Malcolm;Harrington, Thomas. And the article was included in Journal of the Chemical Society in 1940.Recommanded Product: 1843-21-6 This article mentions the following:

PhNCS (20 g.) in 64 g. CHCl₃, treated with Cl without cooling until the increase in weight is 2 g., gives bis(phenylthiocarbimide) oxide, yellow, m. 118°; p-tolyl analog, m. 139°; m-isomer, m. 128°; p-bromophenyl analog; no oxides were obtained from o-MeC₆H₄NCS or from o-, m- and p-O₂NC₆H₄NCS. PhNCS (20 g.) in 10 g. CHCl₃, treated with Cl until the increase in weight is 7 g., gives 1-anilinobenzothiazole (I), m. 159° (picrate, yellow, m. 221°). CS(NHPh)₂ and Br in CHCl₃, boiled 0.5 h., give red needles of a Br addition product; reduction with SO₂ in H₂SO₃ and treatment with hot 2 N NaOH give I. PhNCS (318 g.) in 289 g. PhN:CCl₂ (II), treated with Cl with cooling for 8 h. (increase in weight of 363 g.) gives 256 g. of II, b. 209-11°, d¹⁵ 1.285; the following isocyanodichlorides were prepared by treatment with Cl in 2-3 times their weight of CS₂; they are colorless or pale yellow lachrymatory oils with unpleasant odors: p-bromophenyl, b₁₅ 122-4°, d¹⁵ 1.5; p-anisyl, b₁₅ 155-60°, d¹⁵ 1.5; p-tolyl, b₂₀ 121-4°, d¹⁵ 1.2; m-tolyl, b₁₀ 130°, d¹⁵ 1.35; o-tolyl, b₁₅ 125-30°, d¹⁵ 1.3; m-nitrophenyl, prepared in warm CHCl₃, pale yellow, b₁₅ 165-70°, m. 68°; m-isomer, m. 80°; the o-isomer could not be prepared II (5 g.) and 3.5 g. AcOH in 20 cc. C₆H₆, refluxed 2 h., give CO(NHPh)₂ (III); the o- and p-tolyl analogs were similarly obtained; however, boiling 10 g. II with 25 cc. AcOH in 50 cc. C₆H₆ for 10 h. gives PhNHAc (IV); o-, m- and p-MeC₆H₄NHAc were similarly prepared Thus the reaction with AcOH proceeds as follows: 2II + 3AcOH → III + CO₂ + HCl + 3AcCl; III + AcCl + AcOH → 2IV + CO₂ + HCl. III is only very slowly hydrolyzed to IV by AcOH alone whereas in the presence of AcCl the reaction is rapid and proceeds to completion. The m-tolyl analog yields an unidentified N compound m. 278°. p-BrC₆H₄N:CCl₂ and AcOH in C₆H₆ give (p-BrC₆H₄NH)₂CO on refluxing 5 h. and p-BrC₆H₄NHAc on further boiling; m-O₂NC₆H₄N:CCl₂ behaves similarly. II, PhNH₂ and C₆H₆, refluxed 5 h., give triphenylguanidine-HCl; analogs were prepared as follows, the m. p. of the HCl salt and the free base being given: phenyldi-p-tolyl 222-3°, 109°; m-isomer 206, 93°; o-isomer 205°, 100°; phenyldi-p-bromophenyl 257-62°, oil; p-tolyldiphenyl 230°, 128°; tri-p-tolyl 231°, 125°; p-tolyldi-p-bromophenyl 262-6°, 178°; tri-m-tolyl 221°, 107°; m-tolyldi-p-tolyl 218°, 105°; tri-o-tolyl 213-15°, 129°; o-tolyldi-p-tolyl 205-8°, 87°; tri-p-bromophenyl 270-6° (decomposition), 126°; p-bromophenyldi-p-tolyl 251°, 123°; m-nitrophenyldi-p-tolyl 201-5°, 179°; m-tolyl isomer 218-25°, 139°. The method constitutes a simple approach to the unsym. guanidines. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Recommanded Product: 1843-21-6).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Recommanded Product: 1843-21-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Reactions of 2-(arylamino)benzothiazoles with methyl acrylate was written by Ambartsumova, R. F.. And the article was included in Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) in 2000.Application of 1843-21-6 This article mentions the following:

Addition of 2-(arylamino)benzothiazoles to the C:C bond of CH₂:CHCO₂Me gives a mixture of isomeric 2-(arylimino)-3-[2-(methoxycarbonyl)ethyl]benzothiazolines and 2-{aryl-[2-(methoxycarbonyl)ethyl]amino}benzothiazoles. Their thermal stability was studied. HPLC anal. was used to follow the dynamics of the accumulation of the compounds formed in the reaction mixtures In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Application of 1843-21-6).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Application of 1843-21-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Polymer-Supported Tribromide as a New Solid Phase and Recyclable Catalyst for the Synthesis of 2-(N-Arylamino)benzothiazoles Under Solvent-Free Microwave Irradiation Conditions was written by Nahakpam, Lokendrajit;Chingakham, Brajakishor S.;Laitonjam, Warjeet S.. And the article was included in Journal of Heterocyclic Chemistry in 2015.Name: N-Phenylbenzo[d]thiazol-2-amine This article mentions the following:

The solid-phase synthesis of 2-(N-arylamino)benzothiazoles I (R¹ = H, 4-CH₃, 5-CH₃, 4-OCH₃; R² = H, 2-CH₃, 4-Cl, etc.) was achieved by reacting substituted thioureas with polymer-supported tribromide in high yield under microwave irradiation The method has several advantages such as short reaction time, good yields, and environmentally benign procedure. The catalyst could be recovered conventionally and reused at least four times without loss of its activity. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Name: N-Phenylbenzo[d]thiazol-2-amine).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Name: N-Phenylbenzo[d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ligand-Free Copper-Catalyzed Synthesis of Substituted Benzimidazoles, 2-Aminobenzimidazoles, 2-Aminobenzothiazoles, and Benzoxazoles was written by Saha, Prasenjit;Ramana, Tamminana;Purkait, Nibadita;Ali, Ashif Md;Paul, Rajesh;Punniyamurthy, Tharmalingam. And the article was included in Journal of Organic Chemistry in 2009.Computed Properties of C13H10N2S This article mentions the following:

The synthesis of substituted benzimidazoles, 2-aminobenzimidazoles, 2-aminobenzothiazoles, and benzoxazoles is described via intramol. cyclization of o-bromoaryl derivatives using copper(II) oxide nanoparticles in DMSO under air. E.g., cyclization of o-bromoaryl amidine I gave 95% benzimidazoles II. The procedure is exptl. simple, general, efficient, and free from addition of external chelating ligands. It is a heterogeneous process and the copper(II) oxide nanoparticles can be recovered and recycled without loss of activity. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Computed Properties of C13H10N2S).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Computed Properties of C13H10N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica