Synthesis and study of 2-substituted alkyl or aryl amino benzothiazoles as antituberculosis agents was written by Khadse, B. G.;Patel, Madhuben R.;Lokhande, S. R.. And the article was included in Bulletin of Haffkine Institute in 1979.Related Products of 1843-21-6 This article mentions the following:
2-Aminothiophenol condensed with substituted aryl or alkyl isothiocynanates in a nonpolar solvent at higher temperature to obtain 2-alkyl or substituted aryl aminobenzoles. These were screened for in vitro antituberculosis activity. Eight out of 24 compounds inhibited the growth of H 37 Rv strain of Mycobacterium tuberculosis at concentration 3.12 μg/mL. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Related Products of 1843-21-6).
N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Related Products of 1843-21-6
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica