Category: 1849-73-6

1849-73-6, 7-Chlorobenzo[d]thiazole-2(3H)-thione is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 3-necked round bottomed flask, containing a magnetic stirrer, 32 mg (0.7 mmol) of [3-(5-amino-2-bromo-4-carbamoyl-imidazol-1 -yl)-propyl]-isopropyl- carbamic acid tert-butyl ester, 34 mg (0.4 mmol) of LiBr, 22 mg (0.17 mmol) of potassium te/t-butoxide and 28 mg (0.14 mmol) of 7-chloro-benzothiazole-2- thiol were weighted. The flask was purged with argon and 6 ml_ of distilled DMF were added by syringe. The resulting suspension was stirred overnight at 13O0C. After this, the solvent was removed under high vacuum and the crude was purified through flash chromatography (SiO2, CH2CbZMeOH: 96/4) affording the 3-[5-amino-4-carbamoyl-2-(7-chloro-benzothiazol-2-ylsulfanyl)- imidazol-1-yl]-propyl}-isopropyl-carbamic acid tert-butyl ester compound (14 mg, 34percent) as a foam. 1H-NMR [ CD3OD, delta, ppm]: 7.77 (m, 1 H), 7.38 (m, 1 H), 7.28 (m, 1 H), 4.00 (m, 2H), 3.10 (m, 1 H), 1.90 (m, 4H), 1.42 (s, 9H), 1.01-1.04 (2s, 6H)., 1849-73-6

The synthetic route of 1849-73-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; CRYSTAX PHARMACEUTICALS, S.L.; WO2009/7399; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1849-73-6,7-Chlorobenzo[d]thiazole-2(3H)-thione,as a common compound, the synthetic route is as follows.

A solution of 5-amino-2-bromo-1 -butyl-1 H-imidazole-4- carboxamide (46 mg, 0.17 mmol), potassium te/t-butoxide (64 mg, 0.52 mmol), lithium bromide (76 mg, 0.8 mmol) and 7-chloro-benzothiazole-2-thiol (86 mg, 0.4 mmol) in 7 ml_ of DMF was stirred at 12O0C for 16 h. Removal of the solvent and purification by chromatography on silica (CHCI3/MeOH, 10percent) yielded 5-amino-1 -butyl-2- (7-chloro-benzothiazol-2-ylsulfanyl)-1 H-imidazole-4-carboxamide (33 mg, 49percent) as a foam. 1H-NMR [CDCI3, delta, ppm]: 7.73 (m, 1 H), 7.33 (m, 1 H), 7.26 (m, 1 H), 3.89 (m, 2H, CH2N), 1.54 (m, 2H, CH2), 1.37 (m, 2H, CH2), .0.92 (m, 3H, CH3). MS (El, m/z) 382 (M++1 ).

1849-73-6, 1849-73-6 7-Chlorobenzo[d]thiazole-2(3H)-thione 11171663, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; CRYSTAX PHARMACEUTICALS, S.L.; WO2009/7399; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1849-73-6,7-Chlorobenzo[d]thiazole-2(3H)-thione,as a common compound, the synthetic route is as follows.

In a 3-necked round bottomed flask, containing a magnetic stirrer, 80 mg (0.36mmol) of delta-amino^-bromo-i -methyl-I H-imidazole^- carboxamide, 0.16 g (1.83 mmol) of LiBr, 98 mg (0.80 mmol) of potassium te/t-butoxide and 8.85g (64mmol) of 7-chloro-benzothiazole-2-thiol were weighted. The flask was purged with argon and 6ml of distilled DMF were added by syringe. The resulting suspension was stirred overnight at 13O0C. After this, the solvent was removed under high vacuum and the crude was purified through flash chromatography (SiO2, CH2CI2/MeOH : 96/4 affording the 5-amino-2-(7- chloro-benzothiazol-2-ylsulfanyl)-1 -methyl-1 H-imidazole-4-carboxamide compound (38 mg, 31 percent) as a foam. 1H-NMR [CD3OD, delta, ppm]: 7.81 (m, 1 H), 7.48 (m, 1 H), 7.42 (m, 1 H), 3.56 (s, 3H, CH3). MS (El, m/z) 340 (M++1 )., 1849-73-6

As the paragraph descriping shows that 1849-73-6 is playing an increasingly important role.

Reference：
Patent; CRYSTAX PHARMACEUTICALS, S.L.; WO2009/7399; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1849-73-6, 7-Chlorobenzo[d]thiazole-2(3H)-thione is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,1849-73-6

General procedure: A mixture of the 2-mercaptobenzo[d]thiazole (>1 g, 1 equiv) and sul-furyl chloride (10 equiv) was stirred at 20-25 C for 15 min. Next, H 2 O(2 equiv) was added and the mixture was stirred at 20-25 C for anadditional 3 h. A sample was taken, quenched with MeCN/H 2 O (2:1)and analyzed by HPLC. After completion of the reaction, the mixturewas diluted with MeCN (5 volumes) and slowly quenched with H 2 O(20 volumes). The product precipitated from the aqueous solution.The solid was collected and washed with H 2 O. Drying under vacuumafforded the pure product. In the case of the liquid product 2-chloro-benzo[d]thiazole (13), the reaction mixture was extracted withEtOAc. The organic layer was then dried and concentrated to affordthe product as an oil.

The synthetic route of 1849-73-6 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Wimmer, Laurin; Parmentier, Michael; Riss, Bernard; Kapferer, Tobias; Ye, Chao; Li, Lei; Kim, Hongyong; Li, Jialiang; Synthesis; vol. 50; 10; (2018); p. 2027 – 2032;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1849-73-6, 7-Chlorobenzo[d]thiazole-2(3H)-thione is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of the 2-mercaptobenzo[d]thiazole (>1 g, 1 equiv) and sul-furyl chloride (10 equiv) was stirred at 20?25 °C for 15 min. Next, H 2 O(2 equiv) was added and the mixture was stirred at 20?25 °C for anadditional 3 h. A sample was taken, quenched with MeCN/H 2 O (2:1)and analyzed by HPLC. After completion of the reaction, the mixturewas diluted with MeCN (5 volumes) and slowly quenched with H 2 O(20 volumes). The product precipitated from the aqueous solution.The solid was collected and washed with H 2 O. Drying under vacuumafforded the pure product. In the case of the liquid product 2-chloro-benzo[d]thiazole (13), the reaction mixture was extracted withEtOAc. The organic layer was then dried and concentrated to affordthe product as an oil., 1849-73-6

1849-73-6 7-Chlorobenzo[d]thiazole-2(3H)-thione 11171663, athiazole compound, is more and more widely used in various fields.

Reference：
Article; Wimmer, Laurin; Parmentier, Michael; Riss, Bernard; Kapferer, Tobias; Ye, Chao; Li, Lei; Kim, Hongyong; Li, Jialiang; Synthesis; vol. 50; 10; (2018); p. 2027 – 2032;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica