Category: 18903-18-9

18903-18-9, Ethyl 5-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-Amino-thiazole-4-carboxylic acid ethyl ester (460 mg) obtained in the same manner as in Chem. Pharm. Bull, 19(1) 119-123 (1971) was dissolved in ethanol (7 ml). Hydrazine monohydrate (1.3 ml) was added to this solution and the mixture was refluxed at 100C for 22 hr. The reaction mixture was cooled to room temperature and the obtained solid was collected by filtration and washed with ethanol. This solid was dried in vacuo to give the title compound (280 mg).1H-NMR(?, 300MHz, DMSO-d6) 4.26(2H,s),7.07(2H,s),8.00(1H,s),8.83(1H,s)., 18903-18-9

The synthetic route of 18903-18-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Japan Tobacco Inc.; EP1452526; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

18903-18-9, Ethyl 5-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 24 Intermediate 25 (1.12g, 5.84mmol) and 5-aminothiazole-4-carboxylic acid ethyl ester (0.9g, 5.84mmol) were combined in toluene (25ml_). The mixture was stirred under a nitrogen atmosphere at 60C for 1 hour and then at room temperature for 18 hours. The mixture was partitioned between 1 M hydrochloric acid and ethyl acetate and the layers separated. The aqueous layer was extracted with ethyl acetate and the combined organic layers dried with Na2S04, filtered and concentrated in vacuo to dryness. The residue was purified by chromatography on silica eluting with 0-70% ethyl acetate/cyclohexane. The fractions containing the desired product were combined and the solvents removed by evaporation in vacuo to give Intermediate 24 (298mg) as a cream solid. LCMS (Method 2) Rt 3.09 min; m/z(M+H)+ 328, 18903-18-9

As the paragraph descriping shows that 18903-18-9 is playing an increasingly important role.

Reference£º
Patent; ANTABIO SAS; LEMONNIER, Marc; DAVIES, David; PALLIN, David; WO2014/198849; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18903-18-9,Ethyl 5-aminothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

18903-18-9, To a solution of 2,4-dichloro-1,3,5-triazine (330.5 mg, 2.2 mmol) in dichloromethane (15 mL) at 0 C., ethyl 5-aminothiazole-4-carboxylate (345 mg, 2 mmol) was added, followed by N,N-Diisopropylethylamine (0.523 mL, 3 mmol). The reaction mixture was stirred at 0 C. for 30 minutes. Then more 2,4-dichloro-1,3,5-triazine (300 mg, 2 mmol) was added and the reaction mixture was stirred at room temperature overnight. After this time, the reaction was quenched with saturated sodium bicarbonate solution (PH?8) and extracted with dichloromethane for three times. The combined extracts were washed once with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The crude residue was purified by flash chromatography (silica gel) to give the desired product as white solid. LCMS-ESI+ (m/z): [M+H]+ calcd for C9H9ClN5O2S: 286.7. found: 286.1.

As the paragraph descriping shows that 18903-18-9 is playing an increasingly important role.

Reference£º
Patent; Gilead Sciences, Inc.; Du, Zhimin; Guerrero, Juan A.; Kaplan, Joshua A.; Knox, JR., John E.; Lo, Jennifer R.; Mitchell, Scott A.; Naduthambi, Devan; Phillips, Barton W.; Venkataramani, Chandrasekar; Wang, Peiyuan; Watkins, William J.; Zhao, Zhongdong; (593 pag.)US2016/96827; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18903-18-9,Ethyl 5-aminothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

18903-18-9, Intermediate 4 5-Amino-thiazole-4-carboxylic acid ethyl ester (250mg, 1.453mmol) and triethylamine (1 .02ml_, 7.265mmol) were dissolved in 1 ,4-dioxan (6ml_). To this, 2- chloro-5-(trifluoromethyl)benzene-1 -sulfonyl chloride (0.3mL, 1 .744mmol) was added at room temperature and stirred for 16 hours. The mixture was concentrated in vacuo and extracted with ethyl acetate. The organic layer was washed with 1 N hydrochloric acid solution and water. The organic layer was dried with Na2S04, filtered and concentrated in vacuo. The residue was triturated with n-pentane, the product collected by filtration and dried under vacuum to give Intermediate 4 (340mg). LCMS (Method 26) Rt 2.63 min; m/z(M+H)+ 415

18903-18-9 Ethyl 5-aminothiazole-4-carboxylate 12620181, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ANTABIO SAS; LEMONNIER, Marc; DAVIES, David; PALLIN, David; WO2014/198849; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica