Category: 19654-14-9

New learning discoveries about 19654-14-9

19654-14-9 2-(3-Bromophenyl)benzothiazole 6382460, athiazole compound, is more and more widely used in various fields.

19654-14-9, 2-(3-Bromophenyl)benzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 1,3,5-tris(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene (4) (500 mg, 1.14 mmol), 2-(3-bromophenyl)benzo[d]thiazole (7) (1.15 g, 3.98 mmol), tetrakis(triphenylphosphine)palladium (140 mg, 0.12 mmol), sodium carbonate (1.51 g, 14.2 mmol), THF (25 mL), and water (14 mL) was degassed for 25 minutes. The mixture was heated at reflux (80 C.) overnight under argon. After cooling, the mixture was poured into ethyl acetate (125 mL) then washed with saturated sodium bicarbonate solution (100 mL), water (100 mL), and brine (100 mL). A flash column (gradient of 5 to 10% acetone in hexanes) and precipitation from methylene chloride/methanol gave 611 mg of material (ET-3) in 76% yield., 19654-14-9

19654-14-9 2-(3-Bromophenyl)benzothiazole 6382460, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Zheng, Shijun; US2011/196158; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Brief introduction of 19654-14-9

As the paragraph descriping shows that 19654-14-9 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19654-14-9,2-(3-Bromophenyl)benzothiazole,as a common compound, the synthetic route is as follows.

Intermediate 6 (10.4 g, 35.8 mmol), intermediate 7 (9.20 g, 39.3 mmol), a mixed solution of toluene / ethanol (2: 1, 195 mL), aqueous tripotassium phosphate (2.0 M, ) Were sequentially added, and nitrogen bubbling was carried out for 30 minutes.Pd (PPh 3) 4 (1.00 g, 0.87 mmol) was added thereto, and the mixture was stirred for 3 hours while heating under reflux. After returning to room temperature, distilled water was added and extraction was carried out using toluene.The organic layer was washed with a saturated aqueous sodium chloride solution, dried over magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was subjected to silica gel column chromatography to give Intermediate 8 (13.6 g, yield 95%). Intermediate 6 was synthesized by referring to the method described in International Publication No. 2015/087961., 19654-14-9

As the paragraph descriping shows that 19654-14-9 is playing an increasingly important role.

Reference£º
Patent; MITSUBISHI CHEMICAL CORPORATION; KOMATSU, HIDEJI; ISHIBASHI, KOICHI; NAGAYAMA, KAZUHIRO; (41 pag.)JP2018/58797; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

New learning discoveries about 19654-14-9

19654-14-9 2-(3-Bromophenyl)benzothiazole 6382460, athiazole compound, is more and more widely used in various.

19654-14-9, 2-(3-Bromophenyl)benzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a two-neck 250 mL flask, 2.5 g (5.12 mmol) of Int.3,Intermediate (13) 1.63 g (5.63 mmol0.29 g (0.25 mmol) of Pd(PPh3)4,100 mL of toluene,50 mL of EtOH and 5.12 mL (10.2 mmol) of 2M K2CO3 were mixed, it was refluxed. After the reaction was completed, the reaction mixture was cooled at room temperature and the resulting solid was filtered with EtOH.The solid was dissolved in chloroform and purified by silica gel column chromatography (CHCl3: HEX). Ethyl acetate (EA) was solidified and filtered to obtain 1.62 g (yield: 55.7%) of a beige solid compound 4-415 (WS16-30-211).

19654-14-9 2-(3-Bromophenyl)benzothiazole 6382460, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Raepto Co., Ltd.; Kim Gyu-ri; Go Byeong-su; Kim Hye-jeong; Ryu Yong-jae; Im Cheol-su; Park Yong-pil; Yoon Jeong-hun; Han Gap-jong; Oh Yu-jin; (85 pag.)KR2017/142950; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica