Category: 19759-66-1

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 19759-66-1, C8H5N3S. A document type is Patent, introducing its new discovery., Formula: C8H5N3S

2-hydroxy-benzoic anilide compounds and derivatives, compositions thereof, and methods for treating metabolic diseases and cancer through uncoupling mitochondria.

2-hydroxy-benzoic anilide compounds and derivatives, compositions thereof, and methods for treating metabolic diseases and cancer through uncoupling mitochondria.

Interested yet? Keep reading other articles of 19759-66-1!, Formula: C8H5N3S

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Thiazole | C3H2272NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 19759-66-1. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 19759-66-1, Name is 2-Aminobenzothiazole-6-carbonitrile

Glycogen synthase kinase 3 (GSK-3)has become known for its multifactorial involvement in the pathogenesis of Alzheimer’s disease. In this study, a benzothiazole- and benzimidazole set of 1-aryl-3-(4-methoxybenzyl)ureas were synthesised as proposed Cys199-targeted covalent inhibitors of GSK-3beta, through the incorporation of an electrophilic warhead onto their ring scaffolds. The nitrile-substituted benzimidazolylurea 2b (IC50 = 0.086 ¡À 0.023 muM)and halomethylketone-substituted benzimidazolylurea 9b (IC50 = 0.13 ¡À 0.060 muM)displayed high GSK-3beta inhibitory activity, in comparison to reference inhibitor AR-A014418 (1, IC50 = 0.072 ¡À 0.043)in our assay. The results suggest further investigation of 2b and 9b as potential covalent inhibitors of GSK-3beta, since a targeted interaction might provide improved kinase-selectivity.

Glycogen synthase kinase 3 (GSK-3)has become known for its multifactorial involvement in the pathogenesis of Alzheimer’s disease. In this study, a benzothiazole- and benzimidazole set of 1-aryl-3-(4-methoxybenzyl)ureas were synthesised as proposed Cys199-targeted covalent inhibitors of GSK-3beta, through the incorporation of an electrophilic warhead onto their ring scaffolds. The nitrile-substituted benzimidazolylurea 2b (IC50 = 0.086 ¡À 0.023 muM)and halomethylketone-substituted benzimidazolylurea 9b (IC50 = 0.13 ¡À 0.060 muM)displayed high GSK-3beta inhibitory activity, in comparison to reference inhibitor AR-A014418 (1, IC50 = 0.072 ¡À 0.043)in our assay. The results suggest further investigation of 2b and 9b as potential covalent inhibitors of GSK-3beta, since a targeted interaction might provide improved kinase-selectivity.

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Thiazole | C3H2253NS – PubChem,
Thiazole | chemical compound | Britannica

19759-66-1, 2-Aminobenzothiazole-6-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of benzofurane-2-carbonyl chloride 1 in dry toluene, a solution of corresponding anilines and amino-pyridines 2a-j, 2-aminobenzothiazoles 4a, 4c and 5a and 2-aminobenzimidazoles 4b, 4d and 5b in dry toluene was added dropwise, followed by the addition of Et3N. The mixture was refluxed for several hours. After cooling, the resulting products were filtered off and recrystallized from methanol to obtain benzofurane-2-carboxamides 3a, 3b, 3d-j and 6a-f., 19759-66-1

As the paragraph descriping shows that 19759-66-1 is playing an increasingly important role.

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Article; Hranjec, Marijana; Sovic, Irena; Ratkaj, Ivana; Pavlovic, Gordana; Ilic, Natasa; Valjalo, Linda; Pavelic, Kresimir; Kraljevic Pavelic, Sandra; Karminski-Zamola, Grace; European Journal of Medicinal Chemistry; vol. 59; (2013); p. 111 – 119;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19759-66-1,2-Aminobenzothiazole-6-carbonitrile,as a common compound, the synthetic route is as follows.

General procedure: To a solution of thiophene-2-carbonyl chloride (2a) or3-chlorothiophene-2-carbonyl chloride (2b) in dry tolueneor DMF, corresponding anilines and amino-pyridines 1a-1f, 2-amino-6-subtituted-benzimidazoles 10a-10c, or2-amino-6-substituted-benzothiazoles 10d-10f were added,followed by the addition of Et3N. The mixture was refluxedfor several hours. After cooling, the resulting products werefiltered off and washed with diluted HCl and recrystallizatedfrom ethanol/DMF to obtain heteroaromaticcarboxamides 3a-3f and 11a-11h.

19759-66-1, The synthetic route of 19759-66-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sovi, Irena; Viski, Marko; Bertoa, Branimir; Ester, Katja; Kralj, Marijeta; Hranjec, Marijana; Karminski-Zamola, Grace; Monatshefte fur Chemie; vol. 146; 9; (2015); p. 1503 – 1517;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

19759-66-1, 2-Aminobenzothiazole-6-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0.88g (0.005 mol) 2-amino-6-cyanobenzothiazole was dissolved in 10 mL of N,N-dimethylformamide, 0.4 g (0.01 mol) of sodium hydroxide was added with stirring, After 10 minutes, 1.26 g (0.005 mol) of 2,6-dichloro-3,5-dinitrotoluene was added thereto, The reaction was continued at room temperature for 5 hours. After completion of the TLC monitoring reaction, the reaction solution was poured into 50 mL of saturated brine and extracted with ethyl acetate. The organic phase was extracted with anhydrous magnesium sulfate and evaporated under reduced pressure. The residue was subjected to column chromatography (eluent ethyl acetate and petroleum ether (Boiling range 60-90 C) in a volume ratio of 1:10) to give 0.40 g of compound 4405, Yellow solid. Melting point 229-231 C., 19759-66-1

The synthetic route of 19759-66-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SINOCHEM CORP; Shenyang Research Institute Of Chemical Industry Co., Ltd .; GUAN, AIYING; LI, HUICHAO; SUN, QIN; LIU, CHANGLING; WANG, JUNFENG; SUN, XUFENG; YANG, FAN; (21 pag.)CN104177310; (2016); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica