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The present invention discloses novel conjugates of benzothiazole derivatives with cystine and glucosamine and their method of synthesis. Their method of synthesis is easy and eco-friendly, avoiding the use of hazardous materials or reactions, The compounds offer technical advantages of increased solubility, potency, selectivity and biological activity. The novel compounds show antibacterial, antifungal and anticancer activities. Formula, physico-chemical data and biological activity of the novel derivatives are as given in Tables 1 to 9.

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Reference:
Thiazole | C3H9980NS – PubChem,
Thiazole | chemical compound | Britannica

9-Sep-2021 News Final Thoughts on Chemistry for 2-Amino-4-chlorobenzothiazole

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A regioselective [2+3] cyclocondensation between chlorocarbonylsulfenyl chloride (3) and 2-aminobenzothiazoles gave 3H-1,2,4-thiadiazolo[3,4-b]benzothiazol-3-ones (1). Some heterocycles (1) and their isosteric known 5-substituted 2-methyl-imidazo[2,1-b]benzothiazoles (2) which were prepared from 2-aminobenzothiazoles via two steps, showed significant fungicidal activities.

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Reference:
Thiazole | C3H10070NS – PubChem,
Thiazole | chemical compound | Britannica

Extended knowledge of 19952-47-7

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.category: thiazole. In my other articles, you can also check out more blogs about 19952-47-7

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 19952-47-7, Name is 2-Amino-4-chlorobenzothiazole, category: thiazole.

The condensation of alpha,beta-unsaturated ketones with substituted o-aminothiophenols, obtained by reductive cleavage of the corresponding disulfides in the presence of triphenylphosphine, is an effective method for the synthesis of 2,4-diaryl-2,3-dihydro-1,5-benzothiazepines under neutral conditions.

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Reference:
Thiazole | C3H9989NS – PubChem,
Thiazole | chemical compound | Britannica

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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 19952-47-7, Name is 2-Amino-4-chlorobenzothiazole, Product Details of 19952-47-7.

A number of new pyrrolobenzothiazepine derivatives and a pyrrolobenzothiazocine derivative have been synthesized and evaluated for their affinity towards the ‘peripheral-type’ benzodiazepine receptor (PBR). The new compounds were tested in rat cortex, a tissue expressing a high density of mitochondrial PBR. Some of the pyrrolobenzothiazepines exhibited IC50 values in the low nanomolar range as measured by the displacement of [3H]PK 11195 binding. Compound 4i was found to be the most potent ligand for this receptor in the pyrrolobenzothiazepine subgroup with an IC50 practically identical to that determined for PK 11195. Structure-affinity relationships (SARs) have been developed to elucidate the topology of the PBR binding site.

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Reference:
Thiazole | C3H10073NS – PubChem,
Thiazole | chemical compound | Britannica

Properties and Exciting Facts About 2-Amino-4-chlorobenzothiazole

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Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 19952-47-7, C7H5ClN2S. A document type is Patent, introducing its new discovery., Product Details of 19952-47-7

Provided is a method of decreasing intraocular pressure or improving ocular accommodation in an animal, including a human, comprising administering an intraocular pressure decreasing amount or ocular accommodation improving amount of a compound of the formula I or IA, 1wherein J is oxygen, sulfur, or N?Rd.

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Reference:
Thiazole | C3H10004NS – PubChem,
Thiazole | chemical compound | Britannica

Awesome Chemistry Experiments For 19952-47-7

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.COA of Formula: C7H5ClN2S, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 19952-47-7, in my other articles.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 19952-47-7, Name is 2-Amino-4-chlorobenzothiazole, molecular formula is C7H5ClN2S. In a Article,once mentioned of 19952-47-7, COA of Formula: C7H5ClN2S

Structurally diverse annulated benzothiazoloquinazolines have been synthesized by an environmentally benign, efficient, and convenient synthesis involving three-component domino reaction of 2-aminobenzothiazoles, alpha-tetralone, and furan-2-carbaldehyde/p-methoxybenzaldehyde using an SO3H-functionalized halogen-free ionic liquid ([MIM(CH2)4SO3H][HSO4]) as a catalyst and a reaction medium.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.COA of Formula: C7H5ClN2S, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 19952-47-7, in my other articles.

Reference:
Thiazole | C3H9994NS – PubChem,
Thiazole | chemical compound | Britannica

Brief introduction of 2-Amino-4-chlorobenzothiazole

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 19952-47-7 is helpful to your research., Electric Literature of 19952-47-7

Synthetic Route of 19952-47-7, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 19952-47-7, Name is 2-Amino-4-chlorobenzothiazole, molecular formula is C7H5ClN2S. In a Patent,once mentioned of 19952-47-7

The invention discloses a catalytic process for the preparation of thiazole quinazoline derivatives, which belongs to the technical field of the ionic liquid catalyst. The preparation in the reaction of 2 – amino benzothiazole derivatives, alpha – tetrahydronaphthalene aldehyde molar ratio of 1:1: (1 – 1.1), double-sulfonic acid root acidity of the ionic liquid catalyst is used for the molar amount of 2 – amino benzothiazole derivatives the molar amount of 5 – 8%, in order to millilitres of reaction solvent water is of unwinding to long and fine hair mole of idea 2 – amino benzothiazole derivatives the molar amount of 5 – 7 times, the reaction temperature is 65 – 78 C, the reaction time is 24 – 57 minutes; after the reaction cooled to room temperature, filtered, the filter residue is washed with ethanol, vacuum drying to obtain benzothiazole quinazoline derivatives. This invention compared with the prior preparation method, with little consumption of the catalyst, the catalytic activity is stable, easy to biological degradation and the whole preparation process operation is simple and convenient, a higher degree of green, easy to realize industrial large-scale production. (by machine translation)

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Reference:
Thiazole | C3H9986NS – PubChem,
Thiazole | chemical compound | Britannica

Extended knowledge of 2-Amino-4-chlorobenzothiazole

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 19952-47-7 is helpful to your research., HPLC of Formula: C7H5ClN2S

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.19952-47-7, Name is 2-Amino-4-chlorobenzothiazole, molecular formula is C7H5ClN2S. In a Article,once mentioned of 19952-47-7, HPLC of Formula: C7H5ClN2S

A new series of N,O-acetals were prepared via a simple one-pot reaction by the condensation of 2-amino-methybenzothiazole with aldehydes and alcohols. The title compounds were obtained in moderate to good yields in the presence of acid catalyst. Bioassay results indicated that some synthesized compounds had good herbicidal activity against both dicotyledon and monocotyledon weeds. This investigation provided a new type of herbicidal lead compounds, as well as its facile preparation method.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 19952-47-7 is helpful to your research., HPLC of Formula: C7H5ClN2S

Reference:
Thiazole | C3H10078NS – PubChem,
Thiazole | chemical compound | Britannica

Final Thoughts on Chemistry for 2-Amino-4-chlorobenzothiazole

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Synthesis and ability to displace [3H]diazepam binding from rat brain membranes of the 3-(alkoxycarbonyl)-4H-pyrimido[2,1-b]benzothiazol-4-ones 3a-p and related compounds 10-12 are described. It has been found that some compounds bind to the benzodiazepine receptor (BZR) with potency greater than chlordiazepoxide. From a structure-affinity point of view the substitution at 6-position of pyrimido[2,1-b]benzothiazole nucleus was found conductive to higher affinity. In vitro data (GABA ratio) lend support to the fact that the most active compounds 3j, 1 might possess agonist properties at BZR.

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Reference:
Thiazole | C3H9991NS – PubChem,
Thiazole | chemical compound | Britannica

Extended knowledge of 2-Amino-4-chlorobenzothiazole

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A series of N-substituted 2-(2-chloroacetamido)-3-(furan-2-yl)propanamides (16-18) was prepared through the reaction of chloroacetyl chloride with N-substituted 2-amino-3-(furan-2-yl)propanamides (15), which were obtained via condensation of 2-(tert-butoxycarbonylamido)-3-(furan-2-yl)propanoic acid (Boc-furylalanine) (8) with amines (9, 11, 13), followed by hydrolysis of the resultant N-substituted Boc-furylalanine acid amides (10, 12, 14) in the presence of HCl/dioxane. The biological activity of the prepared 16, 17 and 18 as root growth inhibitors was examined by germination assay using rape seed. At the concentration of 5.0×10-5M, the most active compound, 2-(2-chloroacetamido)-N-(2,6-diethylphenyl)-3-(furan-2-yl)propanamide (16n), showed potent root growth-inhibitory activity of 76% towards rape seedlings.

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Reference:
Thiazole | C3H10057NS – PubChem,
Thiazole | chemical compound | Britannica