Category: 19952-47-7

Application of 19952-47-7. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 19952-47-7, Name is 2-Amino-4-chlorobenzothiazole

Methyl (Z)-2-[(benzyloxycarbonyl)amino]-3-dimethylaminopropenoate (1) was used as a reagent for preparation of 3-[(benzyloxycarbonyl)amino] substituted 4H-pyrido[1,2-a]pyrimidin-4-ones 17-21, 4H-pyrimido[1,2-b]pyridazin-4-ones 22 and 23, 5H-[1,2,4]triazolo[2,3-a]-pyrimidin-5-one 24, 5H-thiazolo[3,2-a]pyrimidin-5-one 25, and 4H-pyrazino[1,2-a]pyrimidin-4-one 26. Removal of the benzyloxycarbonyl group by catalytical transfer hydrogenation with Pd/C in the presence of cyclohexene is selective to give 3-amino-4H-pyrido[1,2-a]-pyrimidin-4-ones 27-30 in 85-92% yields, or with hydrogen bromide in acetic acid to give 3-amino-4H-pyrimido[1,2-b]pyridazin-4-one (31) and 6-amino-5H-thiazolo[3,2-a]pyrimidin-5-one (32) in 80% yields.

Methyl (Z)-2-[(benzyloxycarbonyl)amino]-3-dimethylaminopropenoate (1) was used as a reagent for preparation of 3-[(benzyloxycarbonyl)amino] substituted 4H-pyrido[1,2-a]pyrimidin-4-ones 17-21, 4H-pyrimido[1,2-b]pyridazin-4-ones 22 and 23, 5H-[1,2,4]triazolo[2,3-a]-pyrimidin-5-one 24, 5H-thiazolo[3,2-a]pyrimidin-5-one 25, and 4H-pyrazino[1,2-a]pyrimidin-4-one 26. Removal of the benzyloxycarbonyl group by catalytical transfer hydrogenation with Pd/C in the presence of cyclohexene is selective to give 3-amino-4H-pyrido[1,2-a]-pyrimidin-4-ones 27-30 in 85-92% yields, or with hydrogen bromide in acetic acid to give 3-amino-4H-pyrimido[1,2-b]pyridazin-4-one (31) and 6-amino-5H-thiazolo[3,2-a]pyrimidin-5-one (32) in 80% yields.

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Thiazole | C3H10023NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.19952-47-7, Name is 2-Amino-4-chlorobenzothiazole, molecular formula is C7H5ClN2S. In a Article£¬once mentioned of 19952-47-7, category: thiazole

A novel series of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) inhibitors has been identified. These inhibitors, based on a dibenzazocine core, exhibited picomolar to low nanomolar inhibition of 17beta-HSD3 in cell-free enzymatic as well as in cell-based transcriptional reporter assays.

A novel series of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) inhibitors has been identified. These inhibitors, based on a dibenzazocine core, exhibited picomolar to low nanomolar inhibition of 17beta-HSD3 in cell-free enzymatic as well as in cell-based transcriptional reporter assays.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 19952-47-7 is helpful to your research., category: thiazole

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Thiazole | C3H10076NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 19952-47-7. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 19952-47-7, Name is 2-Amino-4-chlorobenzothiazole

A series of new biologically active phenyl N,N ?-phenyl phosphorodiamidates were synthesized by reacting phenyl phenylphosphoramidochoridate with various amines. All the newly synthesized compounds 3a-j were tested for their antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide (H2O2) and nitric oxide (NO) methods. In all the three methods the compounds 3c (phenyl N-(6-methoxy-1,3-benzothiazol-2-yl)-N?-phenyl-phosphorodiamidate) and 3e (phenyl N-(5-ethyl-1,3,4-thiadiazol-2-yl)-N?-phenylphosphorodiamidate) showed good radical scavenging activity.

A series of new biologically active phenyl N,N ?-phenyl phosphorodiamidates were synthesized by reacting phenyl phenylphosphoramidochoridate with various amines. All the newly synthesized compounds 3a-j were tested for their antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide (H2O2) and nitric oxide (NO) methods. In all the three methods the compounds 3c (phenyl N-(6-methoxy-1,3-benzothiazol-2-yl)-N?-phenyl-phosphorodiamidate) and 3e (phenyl N-(5-ethyl-1,3,4-thiadiazol-2-yl)-N?-phenylphosphorodiamidate) showed good radical scavenging activity.

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Thiazole | C3H10062NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 19952-47-7. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 19952-47-7, Name is 2-Amino-4-chlorobenzothiazole

A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO2) and N-halosuccinimide (NXS) in DMF at room temperature under metal- and acid-free condition is described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide.

A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO2) and N-halosuccinimide (NXS) in DMF at room temperature under metal- and acid-free condition is described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide.

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Thiazole | C3H10072NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 19952-47-7. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 19952-47-7, Name is 2-Amino-4-chlorobenzothiazole

Reaction between substituted thiazolylamine or oxazolylamine, triethyl orthoformate and sodium azide in the presence of tributylmethylammonium chloride in DMSO furnishes 1-substituted 1H-1,2,3,4-tetrazole in high yield.

Reaction between substituted thiazolylamine or oxazolylamine, triethyl orthoformate and sodium azide in the presence of tributylmethylammonium chloride in DMSO furnishes 1-substituted 1H-1,2,3,4-tetrazole in high yield.

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Thiazole | C3H10003NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.19952-47-7, Name is 2-Amino-4-chlorobenzothiazole, molecular formula is C7H5ClN2S. In a Article£¬once mentioned of 19952-47-7, Product Details of 19952-47-7

A series of (<*>fifty) N-substituted 3,6-epoxyhexahydrophthalic acid amides have been prepared by the reaction of exo-cis-7-oxabicyclo<2.2.1>heptane-2,3-dicarboxylic anhydride with primary amines in benzene.Many of the compounds show anticonvulsant activity against electroshock, metrazol, strychnine and picrotoxin induced convulsions.Several compounds are found to be superior to ethosuximide and sodium valproate in anti-electroshock and antimetrazol test systems.

A series of (<*>fifty) N-substituted 3,6-epoxyhexahydrophthalic acid amides have been prepared by the reaction of exo-cis-7-oxabicyclo<2.2.1>heptane-2,3-dicarboxylic anhydride with primary amines in benzene.Many of the compounds show anticonvulsant activity against electroshock, metrazol, strychnine and picrotoxin induced convulsions.Several compounds are found to be superior to ethosuximide and sodium valproate in anti-electroshock and antimetrazol test systems.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Product Details of 19952-47-7, you can also check out more blogs about19952-47-7

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Thiazole | C3H10068NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 19952-47-7, Name is 2-Amino-4-chlorobenzothiazole,molecular formula is C7H5ClN2S, is a conventional compound. this article was the specific content is as follows.Application In Synthesis of 2-Amino-4-chlorobenzothiazole

2-(p-Acetylaminobenzenesulfonylamido)-substituted benzothiazoles were prepared from 2-amino-substituted benzothiazoles and p-acetamidobenzenesulfonyl chloride using a mixture of pyridine and Ac2O, which formed an electrophilic N-acetyl- pyridinium complex facilitating condensation to give the desired products by removal of HCl. 2-[4-(Substituted benzothiazol-2-yl) aminosulfonylanilino]pyridine-3-carboxylic acids (synthesized from 2-chloropyridine-3-carboxylic acid and the corresponding substituted 2-(p-aminobenzenesulfonylamido)benzothiazole in 2-ethoxyethanol using Cu-powder and K2CO3) were then converted to acid chlorides, which on further reaction with piperazine and 4-methoxyphenylpiperazine yielded the corresponding 2-[4-(substituted benzothiazol-2-yl)amino-sulfonyl]anilino-3- (piperazinocarbonyl) pyridine and 2-[4-(substituted benzothiazol-2-yl)amino- sulfonyl]anilino-3-[(4-methoxyphenyl)piperazin-1-yl-carbonyl]pyridine. The structures of the new compounds have been established on the basis of their elemental analyses as well as IR, 1H NMR, and mass-spectral data. All the compounds have been screened for antimicrobial activity and found to possess considerable antibacterial activity.

2-(p-Acetylaminobenzenesulfonylamido)-substituted benzothiazoles were prepared from 2-amino-substituted benzothiazoles and p-acetamidobenzenesulfonyl chloride using a mixture of pyridine and Ac2O, which formed an electrophilic N-acetyl- pyridinium complex facilitating condensation to give the desired products by removal of HCl. 2-[4-(Substituted benzothiazol-2-yl) aminosulfonylanilino]pyridine-3-carboxylic acids (synthesized from 2-chloropyridine-3-carboxylic acid and the corresponding substituted 2-(p-aminobenzenesulfonylamido)benzothiazole in 2-ethoxyethanol using Cu-powder and K2CO3) were then converted to acid chlorides, which on further reaction with piperazine and 4-methoxyphenylpiperazine yielded the corresponding 2-[4-(substituted benzothiazol-2-yl)amino-sulfonyl]anilino-3- (piperazinocarbonyl) pyridine and 2-[4-(substituted benzothiazol-2-yl)amino- sulfonyl]anilino-3-[(4-methoxyphenyl)piperazin-1-yl-carbonyl]pyridine. The structures of the new compounds have been established on the basis of their elemental analyses as well as IR, 1H NMR, and mass-spectral data. All the compounds have been screened for antimicrobial activity and found to possess considerable antibacterial activity.

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Thiazole | C3H10092NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 19952-47-7, Name is 2-Amino-4-chlorobenzothiazole, molecular formula is C7H5ClN2S. In a Article£¬once mentioned of 19952-47-7, Formula: C7H5ClN2S

In an attempt to improve the effectiveness and duration of the action of diltiazem (1), a 1,5-benzothiazepine calcium channel blocker, its derivatives (2) with halogen substituents on the fused benzene ring were synthesized.These compounds were evaluated for their effects on vertebral and coronary blood flows and antihypertensive activity.The structure-activity relationships are discussed.The 8-chloro derivative ((+)-2b), the most potent compound in this series, was selected for clinical evaluation as a cerebral vasodilating and antihypertensive agent.

In an attempt to improve the effectiveness and duration of the action of diltiazem (1), a 1,5-benzothiazepine calcium channel blocker, its derivatives (2) with halogen substituents on the fused benzene ring were synthesized.These compounds were evaluated for their effects on vertebral and coronary blood flows and antihypertensive activity.The structure-activity relationships are discussed.The 8-chloro derivative ((+)-2b), the most potent compound in this series, was selected for clinical evaluation as a cerebral vasodilating and antihypertensive agent.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Formula: C7H5ClN2S. In my other articles, you can also check out more blogs about 19952-47-7

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Thiazole | C3H10030NS – PubChem,
Thiazole | chemical compound | Britannica

19952-47-7, 2-Amino-4-chlorobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General Procedure: A mixture of 2-aminobenzothiazole (0.150g, 1mmol), phenyl isothiocyanate (0.135g, 1 mmol) and Dimethyl amino pyridine (5 mol%) in DMF (1 mL) was stirred at room temperature for 2.0 h and the progress of the reaction was followed by TLC. After completion of the reaction, water (5 mL) was added to reaction mixture and extracted with ethyl acetate (2×5 mL). The organic layer was separated and dried over anhy. Na2SO4, and solvent was removed under reduced pressure. The crude product was purified by column chromatography (60-120 mesh) using (ethyl acetate: n-hexane, 10:90) to obtain 3a (0.256g, 90%) as a white powder.

19952-47-7, As the paragraph descriping shows that 19952-47-7 is playing an increasingly important role.

Reference£º
Article; Kumbhare, Ravindra M.; Dadmal, Tulshiram; Kosurkar, Umesh; Sridhar; Rao, J. Venkateswara; Bioorganic and Medicinal Chemistry Letters; vol. 22; 1; (2012); p. 453 – 455;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

19952-47-7, 2-Amino-4-chlorobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

19952-47-7, General procedure: All microwave irradiation experiments were carried out in CEM-Discover monomode microwavedevice, operating at a frequency of 2.45 GHz. Substituted aminobenzothiazole, equimolar amount ofsubstituted benzaldehyde (1.5 mmol) and mercaptoacetic acid in absolut ethanol (3 mL) were placed ina 10 mL reaction vial containing a stirring bar. The vial was sealed with a Teflon septum and placedinto the microwave cavity. It was irradiated at 100 C using 100 W as maximum power for 30 min.at the end of the reaction the mixture was rapidly cooled with gas jet cooling to room temperature.The clean product was obtained after filter under reduced pressure.

The synthetic route of 19952-47-7 has been constantly updated, and we look forward to future research findings.

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Article; Petrou, Anthi; Eleftheriou, Phaedra; Geronikaki, Athina; Akrivou, Melpomeni G.; Vizirianakis, Ioannis; Molecules; vol. 24; 21; (2019);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica