Category: 2010-06-2

Shaik, Shaheen; Vasa, Sreeja published an article in 2022, the title of the article was Synthesis, characterization and evaluation of semisynthetic derivatives of lawsone.Name: 4-Phenylthiazol-2-amine And the article contains the following content:

Quinones are widely distributed in nature, and several of their synthetic and natural products are very important in many diverse areas of chem. and biochem. They play a fundamental role in several living cells as electron carriers in the respiratory chain, as well as in blood coagulation and carboxylation of glutamates. Due to the intimate relationship between quinones and the biochem. processes of cells, these compounds have been extensively explored in the synthesis 2 of several bioactive compounds with antitumor, molluscicidal, antiparasitic, leishmanicidal, antiinflammatory, antifungal, antimicrobial and trypanocidal activities. In the present work we have synthesized semisynthetic derivatives of lawsone 2(a-d) by Mannich base reaction. Four derivatives of Lawson were synthesized. All the compounds synthesized were obtained in good yields. Purity of compounds was confirmed by TLC and m.ps. and compounds were characterized by preliminary laboratory techniques like chem. tests, m.p., Rf. The synthesized compounds were screened for wound healing activity. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Name: 4-Phenylthiazol-2-amine

The Article related to lawsone semisynthetic derivative synthesis, Pharmaceuticals: Formulation and Compounding and other aspects.Name: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ma, Yu-Nan; Chen, Chuan-Jiao; Li, Qing-Qing; Xu, Fu-Rong; Cheng, Yong-Xian; Dong, Xian published an article in 2019, the title of the article was Monitoring antifungal agents of Artemisia annua against Fusarium oxysporum and Fusarium solani, associated with panax notoginseng root-rot disease.Product Details of 2010-06-2 And the article contains the following content:

Root rot of Panax notoginseng has received great attention due to its threat on the plantation and sustainable utilization of P. notoginseng. To suppress the root-rot disease, natural ingredients are of great importance because of their environment friendly properties. In this study, we found that the methanol extract from Artemisia annua leaves has strong antifungal effects on the growth of Fusarium oxysporum and Fusarium solani resulting into root-rot disease. Essential oil (EO) thereof was found to be the most active. GC-MS anal. revealed 58 ingredients and camphor, camphene, β-caryophyllene, and germacrene D were identified as the major ingredients. Further antifungal assays showed that the main compounds exhibit various degrees of inhibition against all the fungi tested. In addition, synergistic effects between A. annua EO and chem. fungicides were examined Finally, in vivo experiments were conducted and disclosed that P. notoginseng root rot could be largely inhibited by the petroleum ether extract from A. annua, indicating that A. annua could be a good source for controlling P. notoginseng root-rot. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Product Details of 2010-06-2

The Article related to panax fusarium artemisia root rot disease essential oil antifungal, artemisia annua, fusarium oxysporum, fusarium solani, panax notoginseng, essential oil, root rot, Placeholder for records without volume info and other aspects.Product Details of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 30, 2019, Prashanth, T.; Avin, B. R. Vijay; Thirusangu, Prabhu; Ranganatha, V. Lakshmi; Prabhakar, B. T.; Sharath Chandra, J. N. Narendra; Khanum, Shaukath Ara published an article.Recommanded Product: 2010-06-2 The title of the article was Synthesis of coumarin analogs appended with quinoline and thiazole moiety and their apoptogenic role against murine ascitic carcinoma. And the article contained the following:

The synthesis and antiproliferative effect of a series of quinoline and thiazole containing coumarin analogs 12a-d and 13a-f resp., on mice leukemic cells was performed. The chem. structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and mass spectral anal. The result indicates that, 7-methoxy-2-oxo-2H-chromene-3-carboxylic acid [4-(4-methoxy-phenyl)-thiazol-2-yl]-amide (13f) showed potent activity against EAC and DLA cells in MTT (15.3 μM), tryphan blue (15.6 μM) and LDH (14.2 μM) leak assay with 5-fluorouracil as a standard Further, the anti-neoplastic effect of the compound 13f was verified against Ehrlich ascites tumor by BrdU incorporation, TUNEL, FACS and DNA fragmentation assays. Exptl. data showed that compound 13f induces the apoptotic cell death by activating apoptotic factors such as caspase-8 &-3, CAD, Cleaved PARP, γ-H2AX and by degrading genomic DNA of cancer cells and thereby decreasing the ascitic tumor development in mice. Besides, compound 13f was also subjected for docking studies to approve the in vitro and in vivo studies. The data revealed that the compound 13f has very good interaction with caspase 3 protein by binding with amino acid Arg 207 through hydrogen bond. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 2010-06-2

The Article related to ascitic carcinoma coumarin analog quinoline thiazole apoptosis mol docking, antiproliferation, coumarin, in vitro, in vivo, quinoline, thiazole, Placeholder for records without volume info and other aspects.Recommanded Product: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 15, 2020, Hooshyari, Khadijeh; Rezania, Hamidreza; Vatanpour, Vahid; Salarizadeh, Parisa; Askari, Mohammad Bagher; Beydaghi, Hossein; Enhessari, Morteza published an article.Name: 4-Phenylthiazol-2-amine The title of the article was High temperature membranes based on PBI/sulfonated polyimide and doped-perovskite nanoparticles for PEM fuel cells. And the article contained the following:

A new sulfonated aromatic diamine monomer containing nitrogen heterocycles was synthesized and employed to prepare a novel sulfonated polyimide (SPI). To develop proton exchange membranes, new nanocomposite blend membranes consist of the prepared SPI and polybenzimidazole (PBI) were fabricated with incorporation of SrCe0.9Yb0.1O3-δ (SCYb) doped-perovskite nanoparticles with a solution-casting method. The goal of this work is to study the effect of SPI and SCYb doped-perovskite nanoparticles on the important parameters of the PBI membrane specially proton conductivity and fuel cell performance. The proton conductivity and phosphoric acid doping level of the PBI-SPI-SCYb nanocomposite blend membranes improved due to an interaction of -SO3H group and thiazole rings of SPI and N-H groups of PBI in the oxygen vacancies of SCYb doped-perovskite nanoparticles. Substitution of Ce4+ by Yb3+ in the SCYb doped-perovskite nanoparticles produce oxygen vacancies and decrease the columbic repulsion between protons and pos. ions. Furthermore at highest phosphoric acid doping level of 14 mol phosphoric acid per monomer unit, the nanocomposite blend membranes displayed proton conductivity of 131 mS/cm at 180 °C and 8% relative humidity. The increase in power d. from 0.31 W/cm2 in PBI-SPI blend membranes (SPI/PBI: 25 wt%) to 0.59 W/cm2 in PBI-SPI-SCYb nanocomposite blend membranes (SPI/PBI: 25 wt% and 7 wt% of SCYb) was achieved at 0.5 V, 8% RH and 180 °C, which demonstrates that these developed nanocomposite blend membranes have a high potential to be regarded as the most promising candidates for high-temperature fuel cell with improved proton conductivity The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Name: 4-Phenylthiazol-2-amine

The Article related to polybenzimidazole sulfonated polyimide doped perovskite nanoparticle proton exchange membrane, fuel cell, Placeholder for records without volume info and other aspects.Name: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sahni, Tanvi; Sharma, Sunita; Verma, Diksha; Kaur, Harleen; Kaur, Amanpreet published an article in 2022, the title of the article was Synthesis and in vitro Fungitoxic Evaluation of Syringaldehyde Schiff Bases and β-Lactams.Safety of 4-Phenylthiazol-2-amine And the article contains the following content:

Syringic Schiff bases I [R = Ph, Bn, 2-pyridyl, etc.] were synthesized by condensation of syringaldehyde with a number of amines, and in exploratory work two β-lactams II and III were further prepared from their progenitor 4-aminoantipyrene and 4-aminophenol imines. All the compounds were fully characterized and evaluated for their fungitoxicity against four principal phytopathogenic fungi of maize, namely R. solani, D. maydis, M. phaseolina and F. verticilloides. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Safety of 4-Phenylthiazol-2-amine

The Article related to syringaldehyde schiff base preparation antifungal, beta lactam preparation antifungal, General Organic Chemistry: Synthetic Methods and other aspects.Safety of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 31, 2022, Verma, Diksha; Sharma, Sunita; Sahni, Tanvi; Kaur, Harleen; Kaur, Sukhmanpreet published an article.Synthetic Route of 2010-06-2 The title of the article was Designing, antifungal and structure activity relationship studies of Azomethines and β-lactam derivatives of aza heterocyclic amines. And the article contained the following:

The present investigation deals with the synthesis of seven azomethine derivatives I [R1 = 1,2,4-triazol-4-yl, 2-pyridinyl, 4-phenyl-2-thiazolyl,etc.] of aza heterocyclic amines by carrying out condensation reaction of them with veratraldehyde followed by cyclizing the CH=N moiety in synthesized azomethines of 4-amino-1,2,4-triazole and 4-amino antipyrine to yield β lactam derivatives II [R2 = 1,2,4-triazol-4-yl, 1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl]. The chem. constituents in the synthesized compounds were confirmed by UV, IR, 1H NMR, 13C NMR, and elemental anal. In vitro antifungal activity of all the synthesized products was done against four pathogenic maize fungal strains i.e.Fusarium verticillioides, Macrophomina phaseolina, Rhizoctonia solani, and Dreschlera maydis. It was found that azomethine derivative having 4-amino-1,2,4-triazole ring was as effective as standard carbendazim 50 WP against R. solani and may be considered as promising antifungal agent; therefore further modifications may be done in its structure to get better drug candidate in future. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Synthetic Route of 2010-06-2

The Article related to dimethoxyphenyl methanimine preparation agrochem antifungal sar, dimethoxyphenylazetidinone preparation agrochem antifungal sar, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kumar, Ajeet; Joshi, Himanshu published an article in 2019, the title of the article was Lead optimization studies on novel thiazole derivatives as CYP-450 inhibitor by using in-silico modulation.Recommanded Product: 2010-06-2 And the article contains the following content:

The In-silico studies considered as complementary to in vivo and in vitro biol. studies are performed by using a computer and are playing increase larger and more important role in drug discovery and development. We describe here in In-silico study of various hypothetical Thiazole and their interactions with CYP450 enzymes by computational methods including chem draw ultra, Avogadro and ochem database software methods. We worked on a chem. reaction scheme of Thiazole and we prepared different 20 Thiazole derivatives The CYP450 super family of heme enzymes plays an important role in the metabolism of a large number of endogenous and exogenous compounds including most of the drugs currently on the market. Comprehensive studies of the quantum approaches on the Thiazole derivatives like TD1, and TD18 was found to be CYP450 enzymes inhibitors interactions. The quantum approaches by lead optimization will require further studies; the data reported in this work may be helpful guide for medicinal chemist who is working in this area. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 2010-06-2

The Article related to thiazole td1 td18 modulation, Pharmacology: Drug Interactions and General Pharmacology and other aspects.Recommanded Product: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Simic, Dejan; Zaric, Milan; Nikolic, Ivana; Zivkovic-Zaric, Radica; Canovic, Petar; Kocovic, Aleksandar; Radojevic, Ivana; Rakovic, Ivana; Jovicic Milic, Sandra; Petrovic, Djordje; Stojkovic, Danijela; Vukovic, Nenad; Kacaniova, Miroslava; Vukic, Milena; Jevtic, Verica published an article in 2022, the title of the article was Newly synthesized palladium(II) complexes with aminothiazole derivatives: in vitro study of antimicrobial activity and antitumor activity on the human prostate cancer cell line.SDS of cas: 2010-06-2 And the article contains the following content:

Five new complexes of the palladium(II) ion (C1-C5) having the general formula [(PdL2)]Cl2 with some 2-aminothiazoles (L1-L5), where L1 = 2-amino-4-(3,4-difluorophenyl)thiazole, L2 = 2-amino-5-methyl-4-phenylthiazole, L3 = 2-amino-4-phenylthiazole, L4 = 2-amino-4-(4-chlorophenyl)thiazole, and L5 = 2-amino-4-(2,4-difluorophenyl)thiazole, were synthesized and characterized by elemental microanal. and IR, 1H NMR and 13C NMR spectroscopy. The in vitro antimicrobial activity of the five ligands and the corresponding Pd(II) complexes was studied. Testing was performed by the microdilution method and the min. inhibitory concentration (MIC) and min. microbicidal concentration (MMC) were determined Testing is conducted against 11 microorganisms (nine strains of pathogenic bacteria and two yeast species). The tested ligands and palladium(II) complexes show selective, high and moderate activity. There is a difference in antimicrobial activity between the ligands and the corresponding palladium(II) complexes. The complexes have significant anti-staphylococcal activity and activity on Pseudomonas aeruginosa which is better than the pos. control. The interactions of newly synthesized palladium(II) complexes with calf thymus DNA (CT-DNA) were studied using UV-visible absorption and fluorescence spectroscopy. Anal. of UV-absorption and fluorescence spectra indicates the formation of a complex between the palladium(II) complexes and DNA. The high values of intrinsic binding constants, Kb, of the order 104 M-1 and Stern-Volmer quenching constants, KSV, of the order 105 M-1 indicated very good binding of all complexes to CT-DNA. Also, the new Pd(II) complexes show high cytotoxic activity towards the human prostate cancer cell line and insignificant activity towards non-cancerous human fibroblasts. Future research could addnl. explore the biol. activity of Pd(II) complexes presented in this paper and study the possibility of their implementation in clin. practice. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).SDS of cas: 2010-06-2

The Article related to palladium aminothiazole derivative complex preparation antimicrobial antitumor activity, dna interaction palladium aminothiazole derivative complex, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.SDS of cas: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Xing, Shuai; Zhang, Xue; Huang, Xia; Xie, Lin; Jiang, Fengchao; Zhou, Ping published an article in 2019, the title of the article was Modulating the conformation of the TIR domain by a neoteric MyD88 inhibitor leads to the separation of GVHD from GVT.Recommanded Product: 4-Phenylthiazol-2-amine And the article contains the following content:

Graft-vs.-host disease (GVHD) remains the least curable complication after allogeneic bone marrow transplantation (BMT). Myeloid differentiation factor 88 (MyD88) is an adaptor mol. critically involved in the toll-like receptor (TLR) signaling pathway. The Toll/IL-1 receptor (TIR) domains of MyD88 and TLR are interactional modules responsible for sorting and signaling via direct or indirect TIR-TIR interactions, which can contribute to all phases of GVHD progression. Here, we describe the mechanisms of the novel MyD88 inhibitor, TJ-M2010-5, and the discovery of its immunosuppressive properties in the context of GVHD and the graft-vs.-tumor (GVT) effect in a fully MHC-mismatched murine model. TJ-M2010-5 potentially interrupted the conformation of the TIR domain through its predicted DD loops, BB loops, and Poc site, and inhibited the homodimerization of MyD88, the LPS-stimulated activation of dendritic cells, and the priming of donor allogeneic T cell proliferation in a dose-dependent manner. Oral administration of TJ-M2010-5 ameliorated the inflammatory environment, decreased the number of apoptotic cells, increased tissue repair in GVHD target organs, and suppressed lethal GVHD. Further, protection against GVHD by TJ-M2010-5 did not abrogate a GVT effect against SP2/0, a myeloma cell line. Our data define the mechanisms of actions and provide novel insight into the potential clin. uses of TJ-M2010-5 for GVHD prevention. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 4-Phenylthiazol-2-amine

The Article related to tir domain neoteric inhibitor separation gvhd gvt modulating conformation, gvhd, gvt, myd88, tj-m2010-5, tlr, innate immunity, Immunochemistry: Other (Immunity, Immune Suppression, Tolerance, etc.) and other aspects.Recommanded Product: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 30, 2019, Joshi, Shrinivas D.; Kumar, S. R. Prem; Patil, Sonali; Vijayakumar, M.; Kulkarni, Venkatarao H.; Nadagouda, Mallikarjuna N.; Badiger, Aravind M.; Lherbet, Christian; Aminabhavi, Tejraj M. published an article.COA of Formula: C9H8N2S The title of the article was Chemical synthesis, molecular modeling and pharmacophore mapping of new pyrrole derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth. And the article contained the following:

Abstract: Substituted phenylthiazolyl benzamide and pyrrolyl benzamide derivatives were developed using mol. hybridization technique to create novel lead antimycobacterial mols. used to fight against Mycobacteriumtuberculosis. The newly synthesized mols. have inhibited InhA, the enoyl-ACP reductase enzyme from the mycobacterial type II fatty acid biosynthetic pathway. Of these, compound 3b showed H-bonding interactions with Tyr158 and co-factor NAD+ that binds the active site of InhA. All the mols. were screened for in vitro antitubercular activity against M. tuberculosis H37Rv, as well as some representative mols. as the inhibitors of InhA. Thirteen compounds exhibited good anti-TB activities (MIC = 1.6μg/mL), but only few representative mols. showed the moderate InhA enzyme inhibition activity. [Figure not available: see fulltext.]. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).COA of Formula: C9H8N2S

The Article related to pyrrole inhibitor enoylacp reductase, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.COA of Formula: C9H8N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica