Category: 2010-06-2

On June 22, 2022, Liang, Xiao-Ping; Luo, Min; Kang, Li; Tang, Long-Xing; Liang, Qing; Liu, Yuan-Lin; Yang, Zi; Zhang, Chun-Tao; Peng, Cai-Yun; Fu, Rong-Geng published an article.Reference of 4-Phenylthiazol-2-amine The title of the article was Facile one-pot three-component strategy for the synthesis of 2-amino-4-arylthiazoles via elemental sulfur source. And the article contained the following:

A novel and facile metal-free method for the green synthesis of 2-amino-4-arylthiazole derivatives I (Ar = 3-nitrophenyl, 2-naphthyl, pyridin-4-yl, etc.) through the three-component cascade reaction of aromatic Me ketones ArC(O)Me, elemental sulfur and cyanamide is reported. One C-N bond and two C-S bonds were formed in one-pot protocol without using catalysts. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Reference of 4-Phenylthiazol-2-amine

The Article related to amino arylthiazole preparation green chem, aryl methyl ketone sulfur cyanamide three component cascade, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Reference of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 31, 2021, Chen, Yuncan; Lv, Shan; Lai, Ruizhi; Xu, Yingying; Huang, Xin; Li, Jianglian; Lv, Guanghui; Wu, Yong published an article.HPLC of Formula: 2010-06-2 The title of the article was Synthesis of 2-aminothiazoles via rhodium-catalyzed carbenoid insertion/annulation of sulfoxonium ylides with thioureas. And the article contained the following:

Sulfoxonium ylides as carbene precursors couple smoothly with thioureas in the presence of 5 mol% of rhodium(II) acetate dimmer via carbenoid insertion to afford the corresponding 2-aminothiazoles with high chemoselectivity, provided a facile and efficient approach to access a variety of 2-aminothiazole derivatives with good functional groups tolerance. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).HPLC of Formula: 2010-06-2

The Article related to sulfonium ylide thiourea rhodium catalyst chemoselective carbenoid insertion heterocyclization, aminothizaole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.HPLC of Formula: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shaikh, Majid; Shaikh, Mujahed; Sheikh, Anis Ahmed; Kasim, Sayyad Sultan published an article in 2021, the title of the article was Synthesis of 4-aryl-2-aminothiazole using onion extract:a green chemistry approach.Formula: C9H8N2S And the article contains the following content:

The novel green and cost effective protocol was described for the synthesis of most important thiazole moiety by using onion extract as efficient solvent. The synthesis was performed by reaction between acetophenones and N-bromosuccinamide in onion juice medium followed by addition of thiourea. The easy work up ,shorter reaction time , environmentally benign and good to excellent yield of product were some specific features of this protocol. The results obtained were tabulated. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Formula: C9H8N2S

The Article related to acetophenone bromosuccinimide thiourea cyclocondensation ultrasonication green chem, amino phenylthiazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Formula: C9H8N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 27, 2022, Wang, Xingyi; Zhu, Yue; Zhou, Tingting; Yang, Weiqing; Fu, Haiyan; Chen, Hua; Ma, Menglin published an article.Computed Properties of 2010-06-2 The title of the article was Bromine-Mediated C-S Bond Formation: Synthesis of Thiazoles from α-Methylene Ketones by Using Oxone Oxidative System. And the article contained the following:

A novel method for the synthesis of various 2,4,5-trisubstituted thiazoles from methylketones and thiourea/thioacetamide/amidinothiourea using NaBr/Oxone oxidative system was developed. The three intimately connected advantages of this method, which form a whole, are that the reaction underwent a one-pot α-bromination/cyclization process, the use of more common methylene ketones as the raw material rather than α-halomethylene ketones and a cheap and easily available catalytic amount sodium bromide as the bromine source instead of stoichiometric bromine or NBS. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Computed Properties of 2010-06-2

The Article related to ethanone methanethioamide sodium bromide catalyst one pot bromination heterocyclization, thiazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Computed Properties of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 28, 2021, Ujwaldev, Sankuviruthiyil M.; Harry, Nissy Ann; Neetha, Mohan; Anilkumar, Gopinathan published an article.Recommanded Product: 4-Phenylthiazol-2-amine The title of the article was Novel synthesis of 2-Aminothiazoles via Fe(III)-Iodine-catalyzed Hantzsch-type condensation. And the article contained the following:

A novel iron-iodine catalyzed one pot synthesis of 2-aminothiazoles I (Ar = Ph, 4-bromophenyl, furan-2-yl, etc.; R = H, Ph) from Me aryl ketones ArC(O)Me and thioureas RNHC(S)NH2 is demonstrated. This protocol can be considered as a catalyzed version of the classical Hantzsch aminothiazole synthesis I as it enables the in situ generation of α-iodoketones in the reaction medium using catalytic amount of iodine leading to Hantzsch condensation with thiourea. The supply of iodine for multiple catalytic cycles is ensured by using catalytic amounts of iron as it enables iodide to iodine oxidation The generality of this protocol is also well established in this manuscript by synthesizing a variety of 2-aminothiazoles I from different ketones and thiourea. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 4-Phenylthiazol-2-amine

The Article related to aminothiazole preparation green chem, methyl aryl ketone thiourea hantzsch condensation iron iodine catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Recommanded Product: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 5, 2021, Gorji, Samareh; Ghorbani-Vaghei, Ramin; Alavinia, Sedigheh published an article.Related Products of 2010-06-2 The title of the article was Sodium alginate: Biopolymeric catalyst for the synthesis of 2-amino-4-arylthiazole derivatives in aqueous medium. And the article contained the following:

An efficient and recoverable bifunctional heterogeneous organocatalyst for the synthesis of 2-amino-4-arylthiazole derivatives was carried out by the reaction of substituted Ph acetylene and thiourea in an eco-friendly condition in the presence of TBBDA. Mild reaction conditions, simple reaction procedure, easy purification, high yields of products, eco-friendly catalyst usage and convenient reusability were the highlighted points of this protocol. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Related Products of 2010-06-2

The Article related to aryl alkyne thiourea sodium alginate catalyst heterocyclization, amino arylthiazole preparation green chem, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shibasaki, Kaho; Togo, Hideo published an article in 2019, the title of the article was 2-Amino-4-arylthiazoles through One-Pot Transformation of Alkylarenes with NBS and Thioureas.Computed Properties of 2010-06-2 And the article contains the following content:

Treatment of alkylarenes with N-bromosuccinimide in a mixture of Et acetate and water at 60 °C, a mixture of acetonitrile and water at 80 °C, or a mixture of di-Et carbonate and water under irradiation with a tungsten lamp, followed by a reaction with thioureas or arenethioamides provided the corresponding 2-amino-4-arylthiazoles or 2,4-diarylthiazoles in good to moderate yields, resp., in one pot [e.g., ethylbenzene + thiourea → 2-amino-4-phenylthiazole (84%)]. The present reaction is an efficient one-pot transformation method of alkylarenes into 2-amino-4-arylthiazoles and 2,4-diarylthiazoles directly under mild and transition-metal-free conditions. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Computed Properties of 2010-06-2

The Article related to aminoarylthiazole synthesis alkylarene nbs thiourea, arylthiazole synthesis alkylarene nbs arenethioamide, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Computed Properties of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 30, 2022, Li, Pei; Yang, Shang-Feng; Fang, Zi-Lin; Cui, Hao-Ran; Liang, Sen; Tian, Hong-Yu; Sun, Bao-Guo; Zeng, Cheng-Chu published an article.Synthetic Route of 2010-06-2 The title of the article was An efficient one-pot synthesis of 2-aminothiazoles via electrochemically oxidative α-C-H functionalization of ketones with thioureas. And the article contained the following:

An efficient one-pot electrochem. protocol for the synthesis of 2-aminothiazoles was described from electrolysis of ketones with thioureas mediated by iodide ion. The electrochem. synthesis was conducted in an undivided cell equipped with graphite plates electrodes under constant current conditions. A diversity of aromatic and aliphatic ketones were suitable for the reaction, yielding the corresponding 2-aminothiazoles in satisfactory yields. Mechanistically, the in-situ generated α-iodoketone was proposed to be a key active species. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Synthetic Route of 2010-06-2

The Article related to ketone thiourea ammonium iodide tandem electrooxidative cyclization green chem, aminothiazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Synthetic Route of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Safari, Javad; Shokrani, Zahra; Zarnegar, Zohre published an article in 2020, the title of the article was Asparagine as a Green Organocatalyst for the Synthesis of 2-Aminothiazoles.Synthetic Route of 2010-06-2 And the article contains the following content:

In this research, an efficient method for the one-pot synthesis of 2-aminothiazoles via reaction of thiourea with methylcarbonyls in the presence of iodine as an oxidant reagent has been developed using asparagine as a green organocatalyst at 80° in DMSO solvent. Advantages of this efficient method include greener and cleaner conditions, easy isolation of products, higher purity and excellent yield of products, and convenient manipulation. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Synthetic Route of 2010-06-2

The Article related to aminothiazole preparation green chem, methylcarbonyl thiourea cyclocondensation asparagine organocatalyst, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Synthetic Route of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Poola, Sreelakshmi; Gundluru, Mohan; Nadiveedhi, Maheshwara Reddy; Saddala, Madhu Sudhana; P. T. S. R. K., Prasada Rao; Cirandur, Suresh Reddy published an article in 2020, the title of the article was Nano silver particles catalyzed synthesis, molecular docking and bioactivity of α-thiazolyl aminomethylene bisphosphonates.Recommanded Product: 4-Phenylthiazol-2-amine And the article contains the following content:

A new series of α-thiazolyl aminomethylene bisphosphonates I (R1 = H, OCH3, F, Br; R2 = OMe, OEt, OBu, OPh)were synthesized by a three component reaction of 4-aryl substituted thiazol-2-amine with different dialkyl/aryl phosphites and tri-Et orthoformate in the presence of Ag NPs (nano particles) as a catalyst under solvent free conditions. The target compounds were screened for their in vitro antioxidant, antibacterial and antifungal activity. Mol. docking studies were also performed. The results revealed that among the synthesized compounds I (R1 = OCH3, F, Br; R2 = Me) showed remarkably higher antioxidant activity by DPPH and H2O2 than the standard ascorbic acid. Compounds I (R1 = H, OCH3, F; R2 = Me) showed good antibacterial activity and also showed rather higher antifungal activity than the standard flucanozole. Computational docking methods have been used to predict how several aminomethylene bisphosphonate derivatives compete against the inhibitor BPH-1330 at the crystal enzyme structure of the 4H3A protein active site and how substituents influence their binding ability. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 4-Phenylthiazol-2-amine

The Article related to thiazolyl aminomethylene bisphosphonate preparation mol docking antioxidant antibacterial antifungal, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Recommanded Product: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica