Category: 2010-06-2

On July 23, 2020, de Andrade, Vitor S. C.; de Mattos, Marcio C. S. published an article.Formula: C9H8N2S The title of the article was One-pot synthesis of 4-aryl-2-aminothiazoles from styrenes and thioureas promoted by tribromoisocyanuric acid. And the article contained the following:

A simple and efficient one-pot protocol has been developed for the conversion of styrenes into 4-aryl-2-aminothiazoles using readily available starting materials. Tribromoisocyanuric acid was successfully used for the co-bromination and oxidation of styrenes to give phenacyl bromides, which in the presence of thioureas produced the corresponding 4-aryl-2-aminothiazoles in 48-70% yield. The protocol involves three reactions in one process: a tandem (formation of phenacyl bromides from styrenes) followed by a telescoped (conversion to thiazole) reaction. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Formula: C9H8N2S

The Article related to aryl aminothiazole preparation tribromoisocyanuric acid promoter, styrene thiourea tandem reaction, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Formula: C9H8N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 30, 2021, Sanad, Sherif M. H.; Mekky, Ahmed E. M. published an article.Application In Synthesis of 4-Phenylthiazol-2-amine The title of the article was Synthesis and antibacterial evaluation of new pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one hybrids linked to different heteroarene units. And the article contained the following:

A three-component protocol involving the reaction of 3-aminothieno[2,3-b]pyridine-2-carboxylate, Me2NCH(OMe)2 and heteroaryl (bis)amines in dioxane under microwave irradiation yielded a new series of pyrimidinones. The target hybrids were formed by an initial formamidine formation, followed by cross-imidination and [5+1] heterocyclization. Pyrazole-linked pyrimidinones displayed the best antibacterial activity against all gram-pos. and neg. strains tested. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Application In Synthesis of 4-Phenylthiazol-2-amine

The Article related to pyridothienopyrimidinone preparation microwave antibacterial, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application In Synthesis of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 31, 2020, Borthakur, Susanta Kumar; Kalita, Pabitra Kumar; Borthakur, Sukanya published an article.Category: thiazole The title of the article was Synthesis and antifungal activities of 3,5-diphenyl-7-amino-[1,3]-thiazolo[3,2-a]pyrimidine-6-nitrile derivatives. And the article contained the following:

A series of novel 3,7-diphenyl-7-amino[1,3]thiazolo[3,2-a]pyrimidine-6-nitrile derivatives I [R = H, 4-Me, 4-OMe, etc.] was synthesized by refluxing 2-amino-4-phenyl-1,3-thiazole and arylidinemalononitriles in propanol using NaOH as catalyst. Antifungal activities of the synthesized compounds were done by testing against Rhizoctonia solani and Drechslera orazae, two fungal pathogens causing diseases on rice crops. Among the tested compounds, compounds I [R = 4-Cl, 4-NMe2, 4-OMe, 3-OMe-4-OH] showed good to moderate antifungal activity. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Category: thiazole

The Article related to diphenyl amino thiazolopyrimidine nitrile preparation antifungal, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 30, 2021, Abdel-Aziz, Salah A.; Taher, Ehab S.; Lan, Ping; Asaad, Gihan F.; Gomaa, Hesham A. M.; El-Koussi, Nawal A.; Youssif, Bahaa G. M. published an article.Safety of 4-Phenylthiazol-2-amine The title of the article was Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives bearing 1,3-thiazole moiety as novel anti-inflammatory EGFR inhibitors with cardiac safety profile. And the article contained the following:

A new series of pyrimidine-5-carbonitrile derivatives carrying the 1,3-thiazole moiety has been designed and synthesized as novel anti-inflammatory EGFR inhibitors with cardiac and gastric safety profiles and have been assessed for their inhibitory activity against COX-1/COX-2. Compounds 8h, 8n, and 8p (I – III, resp.) were found to be potent and selective COX-2 inhibitors (IC50 = 1.03-1.71μM) relative to celecoxib (IC50 = 0.88μM). The most potent COX-2 inhibitors have been further investigated for their in-vivo anti-inflammatory effect. Compounds 8h, 8n, and 8p showed anti-inflammatory activity up to 90%, 94% and 86% of meloxicam after 4 h interval. 8h, 8n, and 8p showed higher gastric safety profiles than meloxicam. A substantial reduction in serum concentrations of PGE2, TNF-α, IL-6, iNO and MDA and a significant induction of TAC was also observed In vivo experiments on heart rate and blood pressure established the cardiovascular safety profile of 8h, 8n, and 8p. Anti-proliferative and wild-type EGFR inhibitory assays displayed similar results to selective COX-2 inhibition where compounds 8h, 8n, and 8p had a superior inhibition than other tested ones. Mol. docking study demonstrated that these compounds revealed similar orientation and binding interactions as selective COX-2 inhibitors with a higher liability to enter the side pocket selectively. Also, they interacted with EGFR tyrosine kinase main amino acids similar to erlotinib with a strong binding energy score. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Safety of 4-Phenylthiazol-2-amine

The Article related to pyrimidinecarbonitrile thiazole antiinflammatory egfr inhibitor cardiac safety, cox, egfr, il-6, lox, pge(2), pyrimidine, thiazole, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Safety of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 31, 2020, Nizamuddin, N. D.; Abdul Ahad, Hindustan; Devanna, Nayakanti published an article.Application In Synthesis of 4-Phenylthiazol-2-amine The title of the article was Synthesis and molecular docking studies of some 1,2-dimethyl-3(4-substituted phenyl-1,3-thiazol-2-yl)2,3-dihydroquinazolin-4(1H)-ones as anticancer agents. And the article contained the following:

Synthesis of 1, 2-dimethyl-3(4-substituted phenyl-1,3-thiazol-2-yl)2,3-dihydro quinazolin-4(1H)-ones derivatives I [R = 4-Me, 2-OH, 4-Cl, etc.] was effected by refluxing 1,2-dimethylbenzoxazine-4-one with different 4-substituted phenyl-1,3-thiazol-2-amines. Synthesized compoundsI were characterized through elemental anal., IR, proton NMR, and Carbon-13 NMR. Mol. docking studies were carried out using Schrodinger Glide (version 2020_1) which was docked into selective P38alpha and Activin A Receptor Type 1 (ACVR1) Activin receptor-like kinase-2 (ALK2) kinase with Protein Data Bank (PDB) code 3GC7, 6GI6. Based on the docking score of synthesized quinazolin-4-one derivatives, I co-crystallized ligands interaction was evaluated with 5-fluorouracil (5-FU) as a reference drug. Compounds I [R = H, 4-MeO, 3-NH2, 2,4-OH] with P38alpha, I [R = 2-OH, 3-NH2, 4-Cl, 2,4-OH] with ACVR1 (ALK2) kinase score were -7.265, -7.078, -7.058 and -6.836; -8.929, -8.749, -8.735 and -8.464 Kcal/mol against enzymes responsible for cancer treatment. The results indicated that quinazolin-4-one derivatives I scored better than ligand and 5-FU. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Application In Synthesis of 4-Phenylthiazol-2-amine

The Article related to dimethyl phenyl thiazolyl dihydroquinazolinone preparation mol docking, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application In Synthesis of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Goswami, K. V.; Parajapati, S. N.; Goswami, T. K.; Chaudhari, H. D.; Parmar, Kokila A. published an article in 2019, the title of the article was Spectral and microbial screening of one-pot multicomponent synthesis of fused quinazolinone derivatives.Quality Control of 4-Phenylthiazol-2-amine And the article contains the following content:

Heterocyclic compounds containing 2-chloro-3-formyl pyridine and 2-amino thiazole quinqzolin-6(7H)-one I (R = H, Me, OMe; R1 = H, OMe, OH; R2 = H, Me) are reported to possess significant biol. activity. Synthesis of fused quinazolinone derivatives I have been described. The above synthesized compounds have been evaluated for their antimicrobial activity. Among the series containing some of the compounds showed promising results against standard drugs. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Quality Control of 4-Phenylthiazol-2-amine

The Article related to pyridinyl dihydro thiazoloquinazolinone preparation antibacterial antifungal activity, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Quality Control of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 30, 2021, Mohamed Teleb, Mohamed A.; Mekky, Ahmed E. M.; Sanad, Sherif M. H. published an article.Formula: C9H8N2S The title of the article was 3-Aminothieno [2,3-b]pyridine-2-carboxylate: Effective precursor for microwave-assisted three components synthesis of new pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4( 3H )-one hybrids. And the article contained the following:

In this study, Et 3-aminothieno[2,3-b]pyridine-2-carboxylate was taken as a versatile precursor for the one-pot three-component synthesis of related fused pyrimidine hybrids. The tandem protocol involved the reaction of 3-aminothieno[2,3-b]pyridine, dimethylformamide-dimethylacetal, and amines. The reaction afforded a new series of the target pyrimidine hybrids, linked to different arene units I (X = H, NO2, COOEt, etc.), in good to excellent yields. The prior reaction was evaluated in different solvents under traditional heating or microwave irradiation Moreover, the influence of reaction temperature was also examined The optimal conditions were obtained under microwave irradiation in dioxane at 110°C for 40 to 60 min. Addnl., by repeating the previous tandem reaction using the appropriate amines at reaction times of 20 to 60 min, a new series of pyrimidine hybrids linked to alkyl, arylthiazole, and benzo[d]thiazole units has been prepared in good to excellent yields. Furthermore, the utility of bis(amines) was examined to conduct the synthesis of new bis(pyrimidine) hybrids linked to aliphatic cores, in excellent yields, using the same protocol at 30 min reaction time. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Formula: C9H8N2S

The Article related to pyridothienopyrimidinone hybrid preparation microwave irradiation, aminothienopyridine dmf dimethylacetal amine three component reaction, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C9H8N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Mohanta, Prajna Parimita; Pati, Hari Narayan; Behera, Ajaya Kumar published an article in 2020, the title of the article was The construction of fluorophoric thiazolo-[2,3-b]quinazolinone derivatives: a multicomponent domino synthetic approach.Reference of 4-Phenylthiazol-2-amine And the article contains the following content:

Acid-mediated one-pot domino reactions of substituted 2-aminothiazoles, substituted benzaldehydes and cyclic diketones have been developed for the synthesis of novel and architecturally unique thiazolo[2,3-b]quinazolinone derivatives I (Ar = C6H5, 4-CH3OC6H4, 4-BrC6H4, etc.; Ar1 = C6H5, 4-H3CC6H4, 4-ClC6H4, etc.; R1 = R2 = H, CH3) under microwave irradiation In this protocol, a series of thiazolo[2,3-b]quinazolinone derivatives have been synthesized and the excellent fluorescence behaviors of some of the mols. have been reported based on the incorporation of different electron-donating and electron-withdrawing substituents on the aryl moieties of the target mols. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Reference of 4-Phenylthiazol-2-amine

The Article related to thiazoloquinazolinone preparation microwave irradiation fluorescence, aminothiazole benzaldehyde cyclic diketone domino multicomponent reaction, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Reference of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nagaladinne, Nizamuddin; Abdul Ahad, Hindustan; Nayakanti, Devanna published an article in 2020, the title of the article was Design, synthesis and molecular modelling studies of 1-methyl-3-(4-substituted phenyl-1,3- thiazol-2-yl)-2-(pyridin-3-yl)-2,3-dihydroquinazolin-4(1H)-ones as potent anticancer agents.Electric Literature of 2010-06-2 And the article contains the following content:

The present study involved the design, synthesis, characterization and mol. docking studies of biol. active 1-methyl-3-(4-substituted phenyl-1,3-thiazol-2-yl)-2-(pyridin-3-yl)-2,3-dihydroquinazoline-4-(1H)-ones I [R = 2-OH, 3-NH2, 4-Cl, etc.] which were synthesized by condensation of 2-amino-4-substituted phenylthiazoles with N-methylbenzoxazin-4-one. The N-methylbenzoxazin-4-one and 2-amino-4-substituted phenylthiazoles were synthesized from N-methylanthranilic acid with pyridine3-carboxylic acid and substituted aldehydes with thiourea, resp. The ADME properties determined the synthetic accessibility of compounds I by in silico Swiss ADME. The colorectal anticancer screening of compounds I was done by using cell HT-29 human colorectal adenocarcinoma based on mol. docking studies on 3GC7-the structure of p38alpha in complex with dihydroquinazolinone. Finally, compounds I [R = 4-Me, 3-NH2, 2,4-(OH)2, 2,4-(Cl)2] exhibited better activity at a concentration < 10μg/mL when compared to 5-fluorouracil. The ADME properties revealed that all the compounds I were within the range and docking studies showed the highest binding with glide score -7.19 and -7.027 Kcal/mol compared to the target protein -10.67 Kcal/mol. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Electric Literature of 2010-06-2

The Article related to methyl phenyl thiazolyl pyridinyl dihydroquinazolinone preparation antitumor sar admet, mol modeling methyl phenyl thiazolyl pyridinyl dihydroquinazolinone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Electric Literature of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 31, 2019, Rezania, Jafar; Hayatipour, Mohammad; Shockravi, Abbas; Ehsani, Morteza; Vatanpour, Vahid published an article.Product Details of 2010-06-2 The title of the article was Synthesis and characterization of soluble aromatic polyamides containing double sulfide bond and thiazole ring. And the article contained the following:

Novel diamine containing thiazole ring and double sulfide bond was synthesized, and the related polyamides were prepared by a direct polycondensation reaction of this diamine and various aromatic diacids. The polyamides were obtained in good yields and were characterized by differential scanning calorimetry, thermal gravimetric anal., Fourier transform IR, viscosity, solubility, and elemental anal. The glass transition temperatures of synthesized polyamides were in the range of 120-192 °C. The inherent viscosity of these polyamides was in the range of 0.4-0.62 dL/g. The solubility of these polyamides was investigated in some solvents such as DMSO, N-methyl-2-pyrrolidinone, and N,N-dimethylformamide. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Product Details of 2010-06-2

The Article related to aromatic polyamide sulfide bond thiazole ring, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Product Details of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica