Category: 2010-06-2

Rezania, Hamidreza published an article in 2020, the title of the article was Synthesis and characterization of novel functional hyperbranched polyamides from AB2 units: effect of extra functional groups.Category: thiazole And the article contains the following content:

Hyperbranched polymers (HPs), which in terms of structure may be compared to the branching structure of trees, are referred to as tree-like materials, but role of leave in these tree-like polymers is neglected and much attention has only been paid to their branches. In fact, functional groups in these polymers play a vital role the same as the role of leaves in trees. Therefore, in this paper, an attempt has been made to design and synthesize three AB2 monomers containing extra hydroxyl and nitro groups. The benefits of their presence in the structure of produced hyperbranched polyamides (HPs) are investigated. The polymer structure was characterized by FT-IR and 1 H NMR. The solubility of synthesized HPs was studied in different protic and aprotic solvents. The thermal stability of the prepared HPs was investigated by thermogravimetric and differential scanning calorimetric analyses. The photoluminescent properties of the HPs were also investigated. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Category: thiazole

The Article related to hyperbranched polyamide preparation thermal property, novel ab2 monomers, functional groups, hyperbranched polymers, polyamide, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 31, 2019, Igidov, N. M.; Rubtsov, A. E. published an article.Quality Control of 4-Phenylthiazol-2-amine The title of the article was Ring Opening of 4-Arylamino-2-tert-butyl-5-oxo-2,5-dihydrofuran-2-yl Acetates with Aromatic and Heterocyclic Amines. And the article contained the following:

Reactions of 4-arylamino-2-tert-butyl-5-oxo-2,5-dihydrofuran-2-yl acetates I [Ar = 2,4-dichlorophenyl, 2,4-dimethylphenyl, 4-(ethoxy(oxo)methyl)phenyl, etc.] with an equimolar amount of aromatic/heterocyclic amines RNH2 (R =phenyl, 2-bromophenyl, pyridin-2-yl, etc.) in toluene involves initial attack of the amine on the C2 atom of the furan ring, followed by opening of the furan ring and elimination of acetic acid to give N-aryl(hetaryl)-2-arylamino-5,5-dimethyl-4-oxohex-2-enamides RNHC(O)C(=CHC(O)C(CH3)3)NHAr. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Quality Control of 4-Phenylthiazol-2-amine

The Article related to aryl arylamino dimethyl oxo hexenamide preparation diastereoselective, arylamine arylamino tertbutyl oxo dihydrofuranyl acetate ring opening reaction, Aliphatic Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Quality Control of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 31, 2021, Boyarskii, V. P.; Mikherdov, A. S.; Baikov, S. V.; Savko, P. Yu.; Suezov, R. V.; Trifonov, R. E. published an article.Electric Literature of 2010-06-2 The title of the article was Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents. And the article contained the following:

A new diaminocarbene cis-palladium(II) complex containing a 2-aminobenzoxazole ligand was synthesized by reacting cis-[PdCl2(CNCy)2] and 2-aminobenzoxazole. The structure and composition of the obtained complex were proven by NMR spectroscopy and high-resolution mass spectrometry. The cytotoxicities of the obtained complex and structurally similar palladium(II) complexes containing a 2-aminothiazole ligand were tested against human cancer cells of various histogenesis (MCF-7, HL60, HeLa, DLD1, A431). The activities of several complexes against cancer cells were higher than those of the reference drug cisplatin and the free ligands, i.e., 2-aminooxazole and substituted 2-aminothiazoles. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Electric Literature of 2010-06-2

The Article related to diaminocarbene palladium complex aminooxazole aminothiazole preparation human antitumor, Organometallic and Organometalloidal Compounds: Group Viii – Co, Ni, Ru, Rh, Pd, Os, Ir, Pt and other aspects.Electric Literature of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 28, 2022, Daud, Saima; Abid, Obaid-ur-Rahman; Sardar, Asma; Shah, Basit Ali; Rafiq, Muhammad; Wadood, Abdul; Ghufran, Mehreen; Rehman, Wajid; Zain-ul-Wahab; Iftikhar, Fatima; Sultana, Rifhat; Daud, Habiba; Niaz, Basit published an article.Related Products of 2010-06-2 The title of the article was Design, synthesis, in vitro evaluation, and docking studies on ibuprofen derived 1,3,4-oxadiazole derivatives as dual α-glucosidase and urease inhibitors. And the article contained the following:

Present study aimed at the discovery of new non-sugar α-glucosidase inhibitors included synthesis of a series of 1,3,4-oxadiazole based Schiff base derivatives of ibuprofen. Initially oxadiazoles from ibuprofen were synthesized by treating ibuprofen hydrazide with carbon disulfide. Oxadiazoles upon treatment with different substituted phenacyl bromides gave acylated 1,3,4-oxadizole derivatives I [R1 = 2-MeC6H4, 3-MeC6H4, 4-MeC6H4, 4-PhC6H4, 2-O2NC6H4] which further react with amines to gave 1,3,4-oxadiazole based Schiff base derivatives of ibuprofen II [R1 = 2-MeC6H4, 3-MeC6H4, 4-MeC6H4, 4-PhC6H4, 2-O2NC6H4; R2 = Ph, 2-MeC6H4, 2-(4-Ph)thiazolyl]. Synthesized ibuprofen derivatives were characterized by 1H NMR, 13C NMR and HRMS (EI). These derivatives were evaluated in vitro for their α-glucosidase and urease inhibitory activity. In case of α-glucosidase enzyme, all the synthesized derivatives showed potent inhibition in comparison to standard acarbose and the most potent amongst these was the compoundsII [R1 = 4-PhC6H4, R2 = 2-(4-Ph)thiazolyl; R1 = 3-H3CC6H4, R2 = Ph] having IC50 value 16.01 ± 1.27μM and 39.06 ± 0.27μM, resp. In case of urease enzyme, the synthesized derivatives showed varying degree of inhibitory potential, however, potent inhibition was shown by I [R1 = 2-O2NC6H4] (IC50 = 9.36 ± 1.02μM), I [R1 = 4-MeC6H4] (IC50 = 17.65 ± 1.03μM), II [R1 = 4-PhC6H4, R2 = 2-(4-Ph)thiazolyl] (IC50 = 18.29 ± 1.26μM), I [R1 = 2-MeC6H4] (IC50 = 19.52 ± 1.25μM) and II [R1 = 4-PhC6H4, R2 = 2-H3CC6H4] (IC50 = 19.63 ± 1.08μM). The mol. docking was performed in order to check binding interactions between the synthesized derivatives and the enzymes. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Related Products of 2010-06-2

The Article related to oxadiazole schiff base preparation alpha glucosidase inhibitor urease docking, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Related Products of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Chopra, Rakesh; Singh, Lovepreet; Chibale, Kelly; Singh, Kamaljit published an article in 2019, the title of the article was Synthesis, In Silico Molecular Docking, ADME Evaluation and In Vitro Antiplasmodial Activity of Pyrimidine-Based Hybrid Molecules.Category: thiazole And the article contains the following content:

Synthesis of new pyrimidine based mol. hybrids comprising of pyrimidine and aryl/heteroaryl groups linked, conveniently through 1,2,3-triazole. In vitro antiplasdmodial activity of this series of compounds against chloroquine sensitive NF54 strain of the human malaria parasite Plasmodium falciparum, revealed interesting trends and correlation with the physicochem. properties of the hybrids. In silico docking of the most active (IC50 4.40±1.00 μM) (more active than reference artesunate) member 16a in the active binding sites of wild type PfDHFR-TS (P. falciparum Dihydrofolate Reductase-Thymidylate Synthase) and PfDHFR-TS Quadruple mutant showed interactions suggesting their role as PfDHFR inhibitors. Further, all the members of the series showed favorable in silico ADME (Adsorption Distribution, Metabolism, Excretion) profile. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Category: thiazole

The Article related to pyrimidine based hybrid triazoles preparation mol docking antiplasmodial human, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 31, 2022, Peplowski, Lukasz; Szczesny, Robert; Skowronski, Lukasz; Krupka, Anastasiia; Smokal, Vitaliy; Derkowska-Zielinska, Beata published an article.Application of 2010-06-2 The title of the article was Vibrational spectroscopy studies of methacrylic polymers containing heterocyclic azo dyes. And the article contained the following:

This paper presents the IR characterization of methacrylic polymers containing heterocyclic azo dyes thin films using FTIR and Raman spectroscopies. The observed FTIR vibrational frequencies were analyzed and compared with theor. predicted IR spectra. The hybrid-type exchange-correlation potential of Becke, Lee, Yang and Paar (B3LYP) method and 6-311++G(d,p) basis set was applied to calculate polymers spectra. The computed IR spectra showed appreciable agreement with the exptl. results. One can notice that the IR properties of azo dyes polymers strongly depend on the type of substitution in the azobenzene moiety. Different substitution pattern in azobenzene moiety leads to significant changes in the spectrum. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Application of 2010-06-2

The Article related to methacrylic polymer heterocyclic azo dye thin film vibrational spectroscopy, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Azo Dyes and Pigments and other aspects.Application of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lemir, Ignacio D.; Castro-Godoy, Willber D.; Heredia, Adrian A.; Schmidt, Luciana C.; Arguello, Juan E. published an article in 2019, the title of the article was Metal- and photocatalyst-free synthesis of 3-selenylindoles and asymmetric diarylselenides promoted by visible light.Quality Control of 4-Phenylthiazol-2-amine And the article contains the following content:

A novel and sustainable procedure was developed for the synthesis of 3-selenylindoles I = [R1 = H, Me, H2CCH2CH=CH2; R2 = H, Me; R3 = Me, Ph, Bn, etc.] employing diorganyl diselenides and indoles as starting materials. The methodol. was extended to electron-rich arenes to produce diarylselenides. Visible blue light was used to promote the reaction without employing transition metal complexes or organic photocatalysts as sensitizers. Additives such as strong oxidants or bases were not required. Moreover, ethanol was employed as a benign solvent under mild reaction conditions. Through this easy and eco-friendly approach, several 3-selenylindoles I and a number of asym. diarylselenides Ar1SeR4 [Ar1 = Ph; R4 = 4-N(Me)2C6H4, 2,4,6-(HO)3C6H2, etc.] were obtained in good to excellent isolated yields. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Quality Control of 4-Phenylthiazol-2-amine

The Article related to diselenide indole visible light aerobic photochem, selenylindole regioselective green preparation photochem, diaryl selenide regioselective green preparation photochem, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 31, 2021, Masih, Anup; Agnihotri, Amol K.; Srivastava, Jitendra K.; Pandey, Nidhi; Bhat, Hans R.; Singh, Udaya P. published an article.Recommanded Product: 4-Phenylthiazol-2-amine The title of the article was Discovery of novel 1,3,5-triazine as adenosine A2A receptor antagonist for benefit in Parkinson’s disease. And the article contained the following:

Parkinson’s disease (PD) is a chronic neuro-degenerative ailment characterized by impairment in various motor and nonmotor functions of the body. In the past few years, adenosine A2A receptor (A2AR) antagonists have attracted much attention due to significant relief in PD. Therefore, in the current study, we intend to disclose the development of novel 1,3,5-triazines as A2AR antagonist. The radioligand binding and selectivity of analogs were tested in HEK293 (human embryonic kidney) and the cells were transfected with pcDNA 3.1(+) containing full-length human A2AR cDNA and pcDNA 3.1(+) containing full-length human A1R cDNA, where they exhibit selective affinity for A2AR. Mol. docking anal. was also conducted to rationalize the probable mode of action, binding affinity, and orientation of the most potent mol. (7c) at the active site of A2AR. It has been shown that compound 7c form numerous nonbonded interactions in the active site of A2AR by interacting with Ala59, Ala63, Ile80, Val84 Glu169, Phe168, Met270, and Ile274. The study revealed 1,3,5-triazines as a novel class of A2AR antagonists. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 4-Phenylthiazol-2-amine

The Article related to parkinson disease 123 triazine adenosine a2a receptor antagonist, 1,3,5-triazine, parkinson’s disease, adenosine a2a receptor, antagonist, docking, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Recommanded Product: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Eko, Ishegbe Joyce; Ademola, Bello Kasali; Obinna, Nkeonye Peter; Kogo, A. A. published an article in 2019, the title of the article was Synthesis and structural-reactivity studies of bifunctional MCT/SES (monochlorotriazine/sulphatoethylsulphone) azo reactive disperse dyes applied to wool and polyester fabric.Quality Control of 4-Phenylthiazol-2-amine And the article contains the following content:

Reactive disperse dyes containing monochlorotriazine/sulphatoethylsulfone reactive moieties were synthesized by condensing aniline with cyanuric chloride and further reacting it with a series of monoazo dyes obtained by diazotising 1-aminobenzene-4-β-sulphatoethylsulfone and coupling with various substituted 2-amino-4-phenylthiazole derivatives The dyeing performance of the dyes was evaluated on polyester and wool fabrics. The dyes obtained gave various shades ranging from reddish to bright red colors. They had good depth and good leveling properties. They dyed fabrics showed moderate to good light fastness properties and very good to excellent fastness to washing and perspiration. The dye bath exhaustion on the polyester and wool fabrics were found to be very good and their fixation values were moderate. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Quality Control of 4-Phenylthiazol-2-amine

The Article related to monochlorotriazine sulfatoethylsulfone azo reactive disperse dye wool polyester fabric, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Azo Dyes and Pigments and other aspects.Quality Control of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 30, 2022, Elmaaty, Tarek Abou; El-Taweel, Fathy; El-Farh, Abeer Abou; Ramadan, Shaimaa M. published an article.Electric Literature of 2010-06-2 The title of the article was Dyeing Nylon-6 Fabric with New 2-Chloro-N-(4-Aryl-5-Arylazo-Thiazol-2-Yl)-Acetamide Dyes in Supercritical Carbon Dioxide. And the article contained the following:

Abstract: A number of new reactive disperse dyes were synthesized from 2-chloro-N-(4-aryl-5-arylazo-thiazol-2-yl)-acetamide derivatives (5a-d). The new dyestuffs were applied to dye the nylon-6 fabric in supercritical carbon dioxide (scCO2). The chem. structures of these new dyes were explained by elemental and spectroscopic analyses. Then, the suitability of dyestuffs under study for textile dyeing as disperse reactive dyes was reported. All four dyes (5a-5d) exhibited strong color strength, which may be attributed to excellent dye penetration in the fabric afforded by scCO2. The color fastness of dyed samples was measured, and the results demonstrated excellent values and extremely satisfactory washing durability. The dyed samples showed excellent antibacterial activity against Bacillus cereus, Staphylococcus aureus (G+ bacteria), and Escherichia coli (G- bacteria) compared with selected antibiotics as a reference standard; the retention of this excellent antibacterial activity was still satisfactory even after five washing cycles. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Electric Literature of 2010-06-2

The Article related to dyeing nylon fabric chloroarylarylazothiazolylacetamide dye supercritical carbon dioxide, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Azo Dyes and Pigments and other aspects.Electric Literature of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica