Category: 2010-06-2

On August 31, 2022, Nasli Esfahani, Anita; Iraji, Aida; Alamir, Amir; Moradi, Shahram; Asgari, Mohammad Sadegh; Hosseini, Samanesadat; Mojtabavi, Somayeh; Nasli-Esfahani, Ensieh; Faramarzi, Mohammad Ali; Bandarian, Fatemeh; Larijani, Bagher; Hamedifar, Haleh; Hajimiri, Mir Hamed; Mahdavi, Mohammad published an article.Application of 2010-06-2 The title of the article was Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as α-glycosidase inhibitors. And the article contained the following:

A novel series of phenoxymethybenzimidazole derivatives I (R1 = H, 4-F, 4-Br, 4-CH3, 3-OCH3, 4-OCH3; R2 = H, CH3; R3 = H, OCH3) were rationally designed, synthesized, and evaluated for their α-glycosidase inhibitory activity. All tested compounds displayed promising α-glycosidase inhibitory potential with IC50 values in the range of 6.31 to 49.89μM compared to standard drug acarbose (IC50 = 750.0 ± 10.0μM). Enzyme kinetic studies on I (R1 = 4-Br, R2 = R3 = H; R1 = R2 = H, R3 = OCH3; R1 = 4-CH3, R2 = CH3, R3 = H) as the most potent compounds revealed that these compounds were uncompetitive inhibitors into α-glycosidase. Docking studies confirmed the important role of benzimidazole and triazole rings of the synthesized compounds I to fit properly into the α-glycosidase active site. This study showed that this scaffold can be considered as a highly potent α-glycosidase inhibitor. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Application of 2010-06-2

The Article related to phenoxymethybenzimidazole preparation glycosidase inhibitor docking study sar, benzimidazole, enzyme inhibition, synthesis, triazole-acetamide, α-glycosidase, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 25, 2022, Dass, Reuben; Singleton, Justin D.; Peterson, Matt A. published an article.Reference of 4-Phenylthiazol-2-amine The title of the article was An efficient synthesis of 4-Thiocyanato anilines using benzyltrimethylammonium dichloroiodate and ammonium thiocyanate in DMSO:H2O. And the article contained the following:

Treatment of a variety of 2(3)-mono-substituted anilines with benzyltrimethylammonium dichloroiodate (1.2 equiv) and ammonium thiocyanate (1.2 equiv) in DMSO:H2O (9:1) at 70°C gave the corresponding 4-thiocyanato-2(3)-substituted anilines ArSC≡N [Ar = 4-OH-3-MeC6H3, 4-NH2-3-BrC6H3, 3-isoquinolyl, etc.] in excellent isolated yields (60-99%; ave. yield for all anilines = 90%). The reaction worked well for substrates with 2-halo, 2-alkoxy, 2-aryloxy, 2-alkyl, 2-dialkylamino, 2-N-sulfonylamino, 2-alkyn-1-yl, 2-cyano, 2-acyl, 2-sulfonyl, and 2-heteroaryl substitution. 3-Substituted, 3,5- or 2,6-disubstituted anilines and substituted phenols were also well tolerated. 4-Substituted anilines gave the corresponding 2-aminobenzothiazole products ArSC≡N, whereas 4-, 5-, 6-, or 7-substituted indoles were not reactive. Regioselective thiocyanation of 2-quinoline, 3-amino-1-methylpyrazole, 2-amino-4-phenylthiazole, and 2-phenylimidazo[1,2-a] pyridine was achieved in 93-99% yield, thus demonstrating the broad-substrate scope for this thiocyanation reaction. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Reference of 4-Phenylthiazol-2-amine

The Article related to thiocyanatoaniline preparation, aniline ammonium thiocyanate thiocyanation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Reference of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 31, 2020, Shahrivari, Somaye; Kowsari, Elaheh; Shockravi, Abbas; Ehsani, Ali published an article.Safety of 4-Phenylthiazol-2-amine The title of the article was Synthesis and electrochemical capacitor characterization of new copolyimides containing thiazole ring and their composites with conductive polymer. And the article contained the following:

Abstract: In this research work, copolyimides (PIa,b) were synthesized by chem. routs. We used perylene-3,4,9,10-tetracarboxylic dianhydride and synthesized diamines (DAa,b) containing thiazole ring as monomers to obtain PIa,b which were characterized by 1HNMR and FTIR spectroscopies. We prepared POAP/PIa and POAP/PIb by depositing poly ortho amino phenol (POAP) as conductive polymer on the surface of PIa,b via in situ electropolymerization To evaluate the effect of the PIa,b in terms of the electrochem. performance of composites, we used galvanostatic charge/discharge, cyclic voltammetry, and electrochem. impedance spectroscopy. The specific capacitance of 207.2 and 322.4 F/g are obtained for POAP/PIa and POAP/PIb, resp. All these evidences prove that POAP/PI composites have long cycle life as well as high specific capacitance, which are indicative for being a good candidate in terms of application in supercapacitors. Graphic abstract: [Figure not available: see fulltext.]. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Safety of 4-Phenylthiazol-2-amine

The Article related to supercapacitor electrode polyimide thiazolamine ptcda, Electrochemical, Radiational, and Thermal Energy Technology: Energy-Conversion Devices and Their Components and other aspects.Safety of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 1, 2020, Zhang, Wenjuan; Wei, Zhao; Huang, Guozhi; Xie, Fei; Zheng, Zhibing; Li, Song published an article.Synthetic Route of 2010-06-2 The title of the article was Study of triaryl-based sulfamic acid derivatives as HPTPβ inhibitors. And the article contained the following:

A series of novel triaryl-based sulfamic acid analogs I [R = H, 3-FC6H4CH2C(O), 4-MeOC6H4SO2, etc.; Ar = Ph, 4-phenylthiazol-2-yl, 4-(2-thienyl)thiazol-2-yl] was designed, synthesized and evaluated as inhibitors of human protein tyrosine phosphatase beta (HPTPβ). A novel, easy and efficient synthetic method was developed for target compounds I, and the activity determination results showed that most of compounds were good HPTPβ inhibitors. Interestingly, the compounds I [R = 1-tert-butoxycarbonylpiperidine-4-carbonyl, Ar = Ph; R = H, Ar = 4-(2-thienyl)thiazol-2-yl] with simple structure not only showed potent inhibitory activity on HPTPβ but also had good inhibitory selectivity over other PTPs (PTP1B, SHP2, LAR and TC-PTP). The mol. docking simulation of compounds with the protein HPTPβ helped to understand the structure-activity relationship and clarified some confusing assay results. This research provided references for further drug design of HPTPβ and other PTPs inhibitors. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Synthetic Route of 2010-06-2

The Article related to triaryl based sulfamic acid preparation sar docking hptpbeta inhibitor, docking simulation, drug design, hptpβ inhibitor, synthesis, triaryl-based derivatives, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfenic, Sulfinic, and Sulfonic Acids and Derivatives and other aspects.Synthetic Route of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Koohgard, Mehdi; Hosseinpour, Zeinab; Sarvestani, Abdollah Masoudi; Hosseini-Sarvari, Mona published an article in 2020, the title of the article was ARS-TiO2 photocatalyzed direct functionalization of sp2 C-H bonds toward thiocyanation and cyclization reactions under visible light.Electric Literature of 2010-06-2 And the article contains the following content:

An ARS-TiO2 photocatalyst has been prepared by a simple method through stirring a mixture of ARS and TiO2 at room temperature in the dark to extend the photocatalytic response of titanium dioxide toward the visible light spectrum. The synergic effect of ARS and TiO2 in the photocatalyst system has catalyzed direct C-H functionalization of sp2 C-H bonds toward thiocyanation and cyclization reactions. Several aromatic and heteroaromatic scaffolds (2-phenylamino-thiazoles I (R = H, 2-Cl, 4-Ph, etc.), phenols R1OH (R1 = Ph, 3-ethylphenyl, 2-formylphenyl, etc.), anilines R2C6H4N(R3)(R4) (R2 = 2-Me, 3-Cl, 3-OMe, etc.; R3 = H, Me, Et, Ph; R4 = H, Me, Et), indoles II (R5 = H, Me; R6 = H, Me; R7 = H, 5-MeO, 6-methoxycarbonyl, 5-Br, 5-Me) and pyrroles such as 1H-pyrrole and 1-methyl-1H-pyrrole) were treated with the ammonium thiocyanate at room temperature Thiocyanation of phenol and synthesis of 2-aminobenzothiazole derivatives III (R8 = Me, I, prop-1-en-2-yl, etc.) under visible light are presented. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Electric Literature of 2010-06-2

The Article related to thiocyanation cyclization visible light ars photocatalyst regioselective, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.Electric Literature of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 31, 2021, Godugu, Kumar; Shaik, Sultana; Mohinuddin Pinjari, Mohammad Khaja; Gundala, Trivikram Reddy; Chellappa Subramanyam, Dwaraka Viswanath; Loka, Subramanyam Sarma; Divi, Haranath; Vemula, Venkatramu; Reddy Nallagondu, Chinna Gangi published an article.COA of Formula: C9H8N2S The title of the article was Solid state thiazole-based fluorophores: Promising materials for white organic light emitting devices. And the article contained the following:

A facile and more efficient solvent-free mechanochem. synthetic route has been developed for the synthesis of a series of solid state white light emissive thiazole-based donor-acceptor (D-A) type fluorophores, 2-(3-pyridyl)/2-aminothiazoles from ω-bromomethylketones and pyridine-3-carbothioamide/thiourea in the presence of silica-supported HClO4 as a reusable solid Bronsted acid catalyst at RT. The photophys. and electrochem. properties of these compounds have been derived. Most of the studied D-A type solid thiazole-based fluorophores emitted white light and it can be tuned from warm – ideal – cold white light by introduction of a variety of substituents at 4th position of 2-(3-pyridyl)/2-aminothiazoles. Further, HOMO and LUMO energy levels of the titled compounds are found to be in the range -5.52 eV to -5.72 eV and -1.84 eV to -2.45 eV, resp. The lifetimes of these levels of thiazole-based fluorophores have been determined through luminescence decay curves and are found to be in the range of 7.7-11μs. The photophys. and electrochem. properties of the synthesized thiazole-based fluorophores indicate that the compounds could be promising materials for white organic light emitting devices. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).COA of Formula: C9H8N2S

The Article related to solid state thiazole fluorophore organic light emitting device, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Structure Correlation With Physical Properties and other aspects.COA of Formula: C9H8N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Althagafi, Ismail; El-Metwaly, Nashwa M.; Farghaly, Thoraya published an article in 2019, the title of the article was Characterization of new Pt(IV)-thiazole complexes: Analytical, spectral, molecular modeling and molecular docking studies and applications in two opposing pathways.Application of 2010-06-2 And the article contains the following content:

New thiazole derivatives were synthesized and fully characterized, then coordinated with PtCl4 salt. Also, the newly synthesized Pt(IV) complexes were studied anal. (elemental and thermogravimetric analyses), spectrally (IR, UV-visible, mass, 1H NMR, 13C NMR, x-ray diffraction) as well as theor. (kinetics, modeling and docking). The data extracted led to the establishment of the best chem. and structural forms. Octahedral geometry was the only formula proposed for all complexes, which is favorable for d6 systems. The mol. ion peaks from mass spectral anal. coincide with all anal. data, confirming the mol. formula proposed. XRD and SEM allowed discrimination of features between crystalline particles and other amorphous morphol. By applying Gaussian09 as well as HyperChem 8.2 programs, the best structural forms were obtained, as well as computed significant parameters. Computed parameters such as softness, hardness, surface area and reactivity led the authors towards application in two opposing pathways: tumor inhibition and oxidation activation. The catalytic oxidation for CO was conducted over PtO2, which was yielded from calcination of the most reactive complex. The success of catalytic role for synthesized PtO2 was due to its particulate size and surface morphol., which were estimated from XRD patterns and SEM images, resp. The antitumor activity was tested vs. HCT-116 and HepG-2 cell lines. Mild toxicity was recorded for two of the derivatives and their corresponding complexes. This degree of toxicity is more favorable in most cases, due to exclusion of serious side effects, which is coherently attached with known antitumor drugs. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Application of 2010-06-2

The Article related to aminothiazole derivative platinum complexation electronic structure mol docking, platinum aminothiazole derivative preparation antitumor activity thermolysis kinetics qsar and other aspects.Application of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Abdallah, Amira E. M.; Mohareb, Rafat M.; Helal, Maher H. E.; Mofeed, Germeen J. published an article in 2021, the title of the article was Synthesis and anticancer evaluations of novel thiazole derivatives derived from 4-phenylthiazol-2-amine.Application of 2010-06-2 And the article contains the following content:

Many novel thiazole derivatives were designed and synthesized using 4-phenylthiazol-2-amine. The reactivity of the latter compound toward different chem. reagents was studied. The structure of the newly synthesized compounds was established based on elemental anal. and spectral data. Furthermore, twenty compounds of the synthesized systems were selected and evaluated in (μM) as significant anticancer agents towards three human cancer cell lines [MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer)] and normal fibroblasts human cell line (WI-38). The results showed that compounds displayed higher efficiency than the reference doxorubicin. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Application of 2010-06-2

The Article related to heteroaryl thiozole preparation antitumor cytotoxicity structure activity relationship, thiazolopyrimidine preparation antitumor cytotoxicity structure activity relationship and other aspects.Application of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Gari Divya, Kuppi Reddy; Lakshmi Teja, Gaddam; Yamini, Gudi; Padmaja, Adivireddy; Padmavathi, Venkatapuram published an article in 2019, the title of the article was Synthesis of amido sulfonamido heteroaromatics under ultrasonication and their antimicrobial activity.Related Products of 2010-06-2 And the article contains the following content:

A convenient and facile methodol. for N-sulfonylation of heteroaryl amines with Et chlorosulfonylacetate in the presence of dispersed sodium in THF under ultrasonication is reported. The corresponding heteroaryl sulfonamido esters are directly condensed with heteroaryl amines to get amido sulfonamido heteroaromatics in the presence of a mild base in THF under ultrasonication. Utilization of easy reaction conditions, shorter reaction times, and isolation of products in high yields under ultrasonication make this process as economically viable. The compounds 12c, 12d, 12f and 13f are potential antibacterial agents against B. subtilis and the compounds 12f, 13c and 13f are potential antifungal agents against A. niger. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Related Products of 2010-06-2

The Article related to antimicrobial amido sulfonamido heteroaromatic synthesis ultrasonication, n-sulfonylation, antimicrobial activity, azolyl pyrimidines, bispyrimidines, ultrasound irradiation and other aspects.Related Products of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 9, 2020, Maccallini, Cristina; Arias, Fabio; Gallorini, Marialucia; Amoia, Pasquale; Ammazzalorso, Alessandra; De Filippis, Barbara; Fantacuzzi, Marialuigia; Giampietro, Letizia; Cataldi, Amelia; Camacho, Maria Encarnacion; Amoroso, Rosa published an article.SDS of cas: 2010-06-2 The title of the article was Antiglioma Activity of Aryl and Amido-Aryl Acetamidine Derivatives Targeting iNOS: Synthesis and Biological Evaluation. And the article contained the following:

In the present work a set of aryl and amido-aryl acetamidine derivatives were synthesized to obtain new potent and selective inducible Nitric Oxide Synthase inhibitors with improved physicochem. parameters with respect to the previously published mols. Compound I emerged as the most promising inhibitor, and was evaluated on C6 rat glioma cell line, showing antiproliferative effects and high selectivity over astrocytes. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).SDS of cas: 2010-06-2

The Article related to aryl acetamidine hydrobromide preparation nitric oxide synthase inhibition sar, amidoaryl acetamidine preparation antitumor nitric oxide synthase inhibition sar, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.SDS of cas: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica