Category: 20358-00-3

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 20358-00-3, Name is 2-Amino-5-chlorobenzothiazole, molecular formula is C7H5ClN2S. In a Article，once mentioned of 20358-00-3, Product Details of 20358-00-3

Present communication elicits the designing and synthesis of 3-(1,3-benzothiazol-2-yl) 2-phenyl quinazolin-4(3H)-ones as potential antibacterial agents. A number of substituted 2-amino benzothiazoles, 2-amino-5-[(E)-phenyl diazenyl] benzoic acid, and 2-phenyl-4H benzo[d] [1,3] oxazin-4-one were synthesized as the precursor substrates. The compounds were synthesized in excellent yields and the structures were corroborated on the basis of IR, 1H NMR, Mass, and elemental analysis data. These compounds were screened in vitro for their antibacterial activity against a representative panel of Gram positive and Gram negative bacteria and models were generated through quantitative structure-activity relationship (QSAR).The activity contributions due to structural and substituent effects were determined using sequential regression procedure. The antimicrobial assay data show that the synthesized compounds are found to manifest profound antimicrobial activity. Springer Science+Business Media, LLC 2011.

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Reference：
Thiazole | C3H2146NS – PubChem,
Thiazole | chemical compound | Britannica

20358-00-3, Name is 2-Amino-5-chlorobenzothiazole, molecular formula is C7H5ClN2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 20358-00-3, name: 2-Amino-5-chlorobenzothiazole

The present invention discloses a two-fluoro C2 – spiro-indoline compound, is a series of novel compounds, it has better anti-virus activity, is expected to become a kind of novel antiviral drugs. The invention also discloses this kind of indoline compound preparation method. The invention relates to a preparation method of the catalyst and the raw material is cheap; mild reaction conditions, the operation is convenient; wide substrate range, functional group compatibility is good, to a series of two fluoro C2 – spiro indoline product can be achieved good to excellent yield and the like. (by machine translation)

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Reference：
Thiazole | C3H2139NS – PubChem,
Thiazole | chemical compound | Britannica

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A series of 1-hepta-O-benzoyl- beta-D-lactosyl-3-(2) substituted benzothiazolyl carbamides was synthesized by the interaction of hepta-O-benzoyl- beta-D-lactosyl isocyanate with substituted 2-amino benzothiazoles. The identities of these newly synthesized N-lactosylated benzothiazolyl carbamides have been established on the basis of usual chemical transformations and IR, 1H NMR and Mass spectral studies. These compounds were screened for their antibacterial activity and antifungal activity against some selected pathogenic micro-organisms to get potent bioactive molecule.

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Reference：
Thiazole | C3H2173NS – PubChem,
Thiazole | chemical compound | Britannica

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 20358-00-3, C7H5ClN2S. A document type is Article, introducing its new discovery., Computed Properties of C7H5ClN2S

Polarographic and cyclic voltammetric behaviour of twelve titled compounds have been studied in the pH range 2.0-11.2 at dropping mercury electrode, pyrolytic graphite electrode and platinum electrode.The effect of substituents, covering wide range of Hammett substituents constant values, has been evaluated quantitatively.

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Reference：
Thiazole | C3H2148NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 20358-00-3. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 20358-00-3, Name is 2-Amino-5-chlorobenzothiazole. In a document type is Article, introducing its new discovery.

Several N-lactosylated aryl thioureas and benzothiazolyl thioureas have been prepared by the condensation of hepta-O-acetyl-beta-D-lactosyl isothiocyanate with aryl amines and 2-aminobenzothiazole/substituted benzothiazoles. Hepta-O-acetyl-beta-D-lactosyl isothiocyanate was prepared by the interaction of hepta-O-acetyl-alpha-D-lactosyl bromide and lead thiocyanate. The structures of these new N-lactosides have been established on the basis of IR, NMR, and mass spectral studies.

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Reference：
Thiazole | C3H2144NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 20358-00-3, Name is 2-Amino-5-chlorobenzothiazole, molecular formula is C7H5ClN2S. In a Article，once mentioned of 20358-00-3, Safety of 2-Amino-5-chlorobenzothiazole

In continuation of our previous research, several new thiazolyl/thiazolinyl/benzothiazolyl Schiff bases have been designed, synthesized and identified. The referred compounds are reported to act as lipoxygenase inhibitors affecting inflammation and/or psoriasis. The compounds were screened for their reducing activity (with the stable free radical 1,1-diphenyl-2-picryl-hydrazyl, DPPH) and for inhibition of soybean lipoxygenase (LOX). Anti-inflammatory activity was examined in vivo using the carrageenin induced mice paw edema (32.6-75%). The results are discussed in terms of structural and physicochemical characteristics of the compounds. Compound 2d possessed the highest inhibition 75%.

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Reference：
Thiazole | C3H2155NS – PubChem,
Thiazole | chemical compound | Britannica

20358-00-3, Name is 2-Amino-5-chlorobenzothiazole, molecular formula is C7H5ClN2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 20358-00-3, Recommanded Product: 2-Amino-5-chlorobenzothiazole

In a project to find novel neutral P1 fragments for the synthesis of thrombin inhibitors with improved pharmacokinetic properties, fragments containing a benzothiazole guanidine scaffold were identified as weak thrombin inhibitors. WaterLOGSY (Water-Ligand Observed via Gradient SpectroscopY) NMR was used to detect fragments binding to thrombin and these fragments were followed up by Biacore A100 affinity measurements and enzyme assays. A crystal structure of the most potent compound with thrombin was obtained and revealed an unexpected binding mode as well as the key interactions of the fragment with the protein. Based on these results, the structure-based design and synthesis of a small series of optimized novel substituted benzothiazole guanidines with comparatively low pKa values was accomplished. Testing of these compounds against human trypsin I and human trypsin IV revealed unexpected inhibitory activity and selectivity of some of the compounds, making them attractive starting points for selective trypsin inhibitors.

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Reference：
Thiazole | C3H2156NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 20358-00-3, Name is 2-Amino-5-chlorobenzothiazole, molecular formula is C7H5ClN2S. In a Article，once mentioned of 20358-00-3, Recommanded Product: 2-Amino-5-chlorobenzothiazole

2-(p-Acetylaminobenzenesulfonylamido)-substituted benzothiazoles were prepared from 2-amino-substituted benzothiazoles and p-acetamidobenzenesulfonyl chloride using a mixture of pyridine and Ac2O, which formed an electrophilic N-acetyl- pyridinium complex facilitating condensation to give the desired products by removal of HCl. 2-[4-(Substituted benzothiazol-2-yl) aminosulfonylanilino]pyridine-3-carboxylic acids (synthesized from 2-chloropyridine-3-carboxylic acid and the corresponding substituted 2-(p-aminobenzenesulfonylamido)benzothiazole in 2-ethoxyethanol using Cu-powder and K2CO3) were then converted to acid chlorides, which on further reaction with piperazine and 4-methoxyphenylpiperazine yielded the corresponding 2-[4-(substituted benzothiazol-2-yl)amino-sulfonyl]anilino-3- (piperazinocarbonyl) pyridine and 2-[4-(substituted benzothiazol-2-yl)amino- sulfonyl]anilino-3-[(4-methoxyphenyl)piperazin-1-yl-carbonyl]pyridine. The structures of the new compounds have been established on the basis of their elemental analyses as well as IR, 1H NMR, and mass-spectral data. All the compounds have been screened for antimicrobial activity and found to possess considerable antibacterial activity.

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Reference：
Thiazole | C3H2187NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 20358-00-3, Name is 2-Amino-5-chlorobenzothiazole, molecular formula is C7H5ClN2S. In a Article，once mentioned of 20358-00-3, SDS of cas: 20358-00-3

1-Hepta-O-acetyl-beta-D-lactosyl-3-aryl 2/substituted benzothiazolyl carbamides 3 and N-hepta-O-acetyl-beta-D-lactosyl-O-alkyl carbamates 4 have been prepared by the interaction of hepta-O-acetyl-beta-D-lactosyl isocyanate and aryl amines/substituted benzothiazoles and various alcohols respectively. The identities of these newly synthesized compounds are established on the basis of elemental analysis, IR, NMR and mass spectral analysis.

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Reference：
Thiazole | C3H2189NS – PubChem,
Thiazole | chemical compound | Britannica

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2-Amino[1,3]benzothiazoles can be efficiently used as substrates for the Groebke-Blackburn (GB) reaction using equimolar trimethylsilyl chloride (TMSCl) as a promoter. This finding extends the utility of TMSCl in isocyanide-based multicomponent reactions (MCRs) and expands the scope of reactive 2-aminoazole participants for the GBMCR.

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Reference：
Thiazole | C3H2184NS – PubChem,
Thiazole | chemical compound | Britannica