Category: 20358-00-3

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 20358-00-3, Name is 2-Amino-5-chlorobenzothiazole, molecular formula is C7H5ClN2S. In a Article，once mentioned of 20358-00-3, Formula: C7H5ClN2S

Acylaminobenzothiazole hits were identified as potential inhibitors of Trypanosoma cruzi replication, a parasite responsible for Chagas disease. We selected compound 1 for lead optimization, aiming to improve in parallel its anti-T. cruzi activity (IC50 = 0.63 muM) and its human metabolic stability (human clearance = 9.57 mL/min/g). A total of 39 analogues of 1 were synthesized and tested in vitro. We established a multiparametric structure-activity relationship, allowing optimization of antiparasite activity, physicochemical parameters, and ADME properties. We identified compound 50 as an advanced lead with an improved anti-T. cruzi activity in vitro (IC50 = 0.079 muM) and an enhanced metabolic stability (human clearance = 0.41 mL/min/g) and opportunity for the oral route of administration. After tolerability assessment, 50 demonstrated a promising in vivo efficacy.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Formula: C7H5ClN2S, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 20358-00-3, in my other articles.

Reference：
Thiazole | C3H2163NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.20358-00-3, Name is 2-Amino-5-chlorobenzothiazole, molecular formula is C7H5ClN2S. In a Article，once mentioned of 20358-00-3, Application In Synthesis of 2-Amino-5-chlorobenzothiazole

VILSMEIER-HAACK REACTION OF 2-AMINO-X-BENZOTHIAZOLES WITH N-PHENYLFORMAMIDE IN THE PRESENCE OF BENZENESULFONYL CHLORIDE

2-Amino-X-benzothiazoles (X = H, 4-Cl, 6-Cl, 6-NO2, 6-CH3, 6-OCH3, 6-Br) react with N-phenylformamide and two equivalents of benzenesulfonyl chloride in pyridine, affording different products in dependence on the substituent X: N-(X-2-benzothiazolyl)formamidines, N-phenyl-N’-(X-2-benzothiazolyl)formamidines, N-phenyl-N’,N”-bis(X-2-benzothiazolyl)triaminomethanes, N-(X-2-benzothiazolyl)benzenesulfonamides and N-2-((X-3-phenyliminomethyl)benzothiazolylidene)benzenesulfonamides.In the presence of one equivalent of benzenesulfonyl chloride, benzothiazoles I either do not react or are partially benzenesulfonated.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of 2-Amino-5-chlorobenzothiazole, you can also check out more blogs about20358-00-3

Reference：
Thiazole | C3H2183NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.20358-00-3, Name is 2-Amino-5-chlorobenzothiazole, molecular formula is C7H5ClN2S. In a Article，once mentioned of 20358-00-3, Application In Synthesis of 2-Amino-5-chlorobenzothiazole

VILSMEIER-HAACK REACTION OF 2-AMINO-X-BENZOTHIAZOLES WITH N-PHENYLFORMAMIDE IN THE PRESENCE OF BENZENESULFONYL CHLORIDE

2-Amino-X-benzothiazoles (X = H, 4-Cl, 6-Cl, 6-NO2, 6-CH3, 6-OCH3, 6-Br) react with N-phenylformamide and two equivalents of benzenesulfonyl chloride in pyridine, affording different products in dependence on the substituent X: N-(X-2-benzothiazolyl)formamidines, N-phenyl-N’-(X-2-benzothiazolyl)formamidines, N-phenyl-N’,N”-bis(X-2-benzothiazolyl)triaminomethanes, N-(X-2-benzothiazolyl)benzenesulfonamides and N-2-((X-3-phenyliminomethyl)benzothiazolylidene)benzenesulfonamides.In the presence of one equivalent of benzenesulfonyl chloride, benzothiazoles I either do not react or are partially benzenesulfonated.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of 2-Amino-5-chlorobenzothiazole, you can also check out more blogs about20358-00-3

Reference：
Thiazole | C3H2183NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 20358-00-3, Name is 2-Amino-5-chlorobenzothiazole, molecular formula is C7H5ClN2S. In a Article£¬once mentioned of 20358-00-3, Recommanded Product: 2-Amino-5-chlorobenzothiazole

2-Amino substituted benzothiazoles 2a-l and 2-chloropyridine-3-carboxylic acid 3 were used to prepare 2-[N-(substitutedbenzothiazolyl)amino]pyridine-3- carboxylic acids (4a-l) in 2-ethoxy ethanol. Acid chlorides (5a-l) were condensed with 2-hydroxyethyl piperazine (6) and 2,3-dichloropiperazine (7) to prepare amide derivatives 2-[N-(substituted benzothiazolyl)amino]pyridin-3-yl (4-(2-hydroxyethyl)piperazin-1-yl)methanones (8a-l) and 2-[N-(substituted benzothiazolyl) amino]pyridin-3-yl(2,3- dichloropiperazine-1-yl)methanones (9a-l), respectively. The structures of new compounds have been established on the basis of elemental analysis and spectral (IR, 1H NMR, and Mass spectra) studies. The in vitro antimicrobial activity was screened for all the synthesized compounds. Variable and modest activity were observed against the investigated strains of bacteria and fungi. Springer Science+Business Media, LLC 2010.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: 2-Amino-5-chlorobenzothiazole. In my other articles, you can also check out more blogs about 20358-00-3

Reference£º
Thiazole | C3H2185NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 20358-00-3, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 20358-00-3, Name is 2-Amino-5-chlorobenzothiazole, molecular formula is C7H5ClN2S. In a Patent£¬once mentioned of 20358-00-3

Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, (4) disorders associated with viral infections, and/or (5) non-proliferative metabolic disorders such as type II diabetes where inhibition of translation initiation is beneficial using the compounds disclosed herein.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 20358-00-3 is helpful to your research., Electric Literature of 20358-00-3

Reference£º
Thiazole | C3H2161NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 20358-00-3. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 20358-00-3, Name is 2-Amino-5-chlorobenzothiazole

In the presence of a nickel(0) complex, 1,2-aminoiodoarenes underwent the reaction with thioureas to provide a facile, site-specific, and general synthetic procedure of 2-benzothiazolamine and its derivatives under non-oxidative conditions.

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Reference£º
Thiazole | C3H2154NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 20358-00-3, Name is 2-Amino-5-chlorobenzothiazole,molecular formula is C7H5ClN2S, is a conventional compound. this article was the specific content is as follows.SDS of cas: 20358-00-3

In this study, a novel benzothiazol- and benzooxazol-2-amine scaffold with antibacterial activity was designed and synthesized. Preliminary structure-activity relationship analysis displayed that compound 8t with a 5,6-difluorosubstituted benzothiazole was found to be a potent inhibitor of Gram-positive pathogens, and exhibited some potential against drug-resistant bacteria and without cytotoxicity in therapeutic concentrations. In addition, molecular docking studies indicated that Staphylococcus aureus methionyl-tRNA synthetase might be the possible target of these compounds. Taken together, the present study provides an effective entry to the synthesis of a good lead for subsequent optimization and a new small molecule candidate drug for antibacterial therapeutics.

In this study, a novel benzothiazol- and benzooxazol-2-amine scaffold with antibacterial activity was designed and synthesized. Preliminary structure-activity relationship analysis displayed that compound 8t with a 5,6-difluorosubstituted benzothiazole was found to be a potent inhibitor of Gram-positive pathogens, and exhibited some potential against drug-resistant bacteria and without cytotoxicity in therapeutic concentrations. In addition, molecular docking studies indicated that Staphylococcus aureus methionyl-tRNA synthetase might be the possible target of these compounds. Taken together, the present study provides an effective entry to the synthesis of a good lead for subsequent optimization and a new small molecule candidate drug for antibacterial therapeutics.

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Reference£º
Thiazole | C3H2152NS – PubChem,
Thiazole | chemical compound | Britannica