With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20358-06-9,4-Fluorobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.
General procedure: Compound 9 (0.1mmol) added to dry CH2Cl2 (15mL) was stirred at 0C and oxalyl chloride (2.0mmol) was dripped into the mixture and stirred at the same temperature for 12h. After the reaction, the solvent and excess oxalyl chloride was evaporated under the reduced pressure, then add CHCl3. Compounds 2 (0.1mmol) and triethylamine (0.15mmol) were added to the mixture and reflux at 65C for 5h. After the reaction, the solvent was evaporated under reduced pressure, and the crude product was purified by chromatography on silica gel eluted with petroleum CH2Cl2/CH3OH (V: V=60:1) to offer the target compounds 11a-11k in good yields., 20358-06-9
As the paragraph descriping shows that 20358-06-9 is playing an increasingly important role.
Reference£º
Article; Jin, Le; Huang, Rizhen; Huang, Xiaochao; Zhang, Bin; Ji, Min; Wang, Hengshan; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 1759 – 1775;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica