Category: 20582-55-2

Zhu, Peng-Wei; Yang, Yan-Tong; Li, Yang; Zhu, Jie; Wu, Lei published the artcile< Electrochemical Oxidative C-H Phosphonylation of thiazole derivatives in ambient conditions>, HPLC of Formula: 20582-55-2, the main research area is electrochem oxidative phosphonylation thiazole green chem; organophosphorus phosphine oxide preparation green electrochem.

We herein report a direct electrochem. dehydrogenative C-H phosphonylation of thiazoles derivatives with H2 evolution. Employing electricity as the green and sole oxidant, cheap metal as electrode, the anodic oxidation together with cathodic hydrogen evolution process provides a green and efficient strategy for C-H phosphonylation. A diverse range of phosphorus products were constructed under external metal and oxidant-free conditions at ambient temperature, featuring atom economy, simple operation and wide reaction scope.

Molecular Catalysis published new progress about Electricity. 20582-55-2 belongs to class thiazole, and the molecular formula is C7H9NO2S, HPLC of Formula: 20582-55-2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Haake, Paul; Bausher, Larry P. published the artcile< Thiazolium ions and related heteroaromatic systems. II. The acidity constants of thiazolium, oxazolium, and imidazolium ions>, Product Details of C7H9NO2S, the main research area is thiazolium acidity constant; oxazolium acidity constant; imidazolium acidity constant.

The pKa’s of the protonated forms of several oxazoles, thiazoles, and imidazoles were determined Oxazoles are ∼106 less basic than imidazoles, and thiazoles are ∼104 less basic than imidazoles. The pK’s for azolium acids indicate that zwitterionic forms are favored for imidazole acids, but uncharged forms are favored for thiazole and oxazole acids.

Journal of Physical Chemistry published new progress about Ionization. 20582-55-2 belongs to class thiazole, and the molecular formula is C7H9NO2S, Product Details of C7H9NO2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Jeong, Siyeon; Kim, Eunmin; Kim, Minkyu; Hwang, Ye Ji; Padhi, Birakishore; Choi, Jonghoon; Lee, Yunho; Joo, Jung Min published the artcile< Divergent Strategies for the π-Extension of Heteroaryl Halides Using Norbornadiene as an Acetylene Synthon>, Category: thiazole, the main research area is three component reaction norbornadiene norbornene diheteroarylation cycloannulation.

Pd-catalyzed multicomponent coupling reactions of five-membered heteroaryl halides and norbornadiene (NBD) were developed. Either direct addition of (benzo)azoles or 2:1 annulation was achieved depending on the propensity of the intermediate complex to undergo palladacycle formation, determined by the nature and substitution pattern of the heteroarene. The obtained exo- and cis-diheteroaryl norbornenes underwent epimerization and retro-Diels-Alder reactions to afford the corresponding trans-isomers and π-extended heteroaromatic systems, resp., demonstrating the versatility of NBD as an acetylene synthon.

Organic Letters published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 20582-55-2 belongs to class thiazole, and the molecular formula is C7H9NO2S, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Doughty, Michael B.; Risinger, G. E.; Jungk, Steven J. published the artcile< Chemistry of the tricyclic form of thiamin with aldehydes in basic ethanol>, COA of Formula: C7H9NO2S, the main research area is thiamin aldehyde reaction; hydroxybenzylthiamin; pyrimidinylmethylfurothiazole; furothiazole pyrimidinylmethyl.

Upon the addition of PhCHO to basic thiamin solution gives an intermediate accumulates which gives rise to 2-(1-hydroxyphenylmethyl)thiamin-HCl upon acidification of the reaction mixture and high yields of both 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-benzoyl-3a-methylperhydrofuro[2,3-d]thiazole and benzoin when the reaction mixture is stirred for 5 h. Given that thiamin is unstable under these conditions such that it is converted completely to its tricyclic species, the 2-(1-hydroxyalkyl)thiamin salts, which have an increased base lability due to the addition of a C-2/N-3 torsional interaction to the base-labile thiazolium ring, would also not be expected to accumulate in appreciable concentrations under identical conditions. Based on product isolation and the synthesis of 2-benzoyl-3,4-dimethyl-5-ethoxycarbonyl-[2H]-thiazoline in the reaction of 3,4-dimethyl-5-ethyoxycarbonylthiazolium iodide with PhCHO in basic MeOH, the intermediate which accumulates during the reaction of the tricyclic form of thiam with PhCHO is a 2-benzoylthiazoline in equilibrium with a low concentration of its enol isomer. Reasons for the increased catalytic power of thiamin under these conditions, as well as the relevance of this chem. to the active site chem. of thiamin pyrophosphate, are discussed.

Bioorganic Chemistry published new progress about 20582-55-2. 20582-55-2 belongs to class thiazole, and the molecular formula is C7H9NO2S, COA of Formula: C7H9NO2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kikelj, D.; Urleb, U. published the artcile< Product class 17: thiazoles>, Formula: C7H9NO2S, the main research area is review thiazole preparation.

A review of synthetic methods to prepare thiazoles as well as reactive modifications of thiazole moieties.

Science of Synthesis published new progress about Cyclization. 20582-55-2 belongs to class thiazole, and the molecular formula is C7H9NO2S, Formula: C7H9NO2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Liu, Shihui; Pan, Peng; Fan, Huaqiang; Li, Hao; Wang, Wei; Zhang, Yongqiang published the artcile< Photocatalytic C-H silylation of heteroarenes by using trialkylhydrosilanes>, Formula: C7H9NO2S, the main research area is photocatalytic silylation heteroarene hydrosilane green chem.

The efficient and selective C-H silylation of heteroarenes, especially the pharmaceutically relevant electron-deficient heteroarenes, represents a great challenge in organic synthesis. Herein we wish to report a distinctive visible light-promoted photocatalytic C-H silylation approach that enables the direct coupling of trialkylhydrosilanes with both electron-deficient and -rich heteroarenes as well as with cyano-substituted arenes in moderate to high yields and with good regioselectivity. The protocol features operational simplicity, mild reaction conditions, and the use of safe and readily available Na2S2O8, bis(trimethylsilyl) peroxide (BTMSPO) or iPr3SiSH as the radical initiators. Notably, the challenging bulky and inert trialkylhydrosilanes, such as (t-butyldimethyl)silane (tBuMe2SiH) and (triisopropyl)silane (iPr3SiH), work smoothly with the protocol. Moreover, despite the higher stability of tBuMe2Si silylation products, our studies revealed their great reactivity and versatility in diverse C-Si-based chem. transformations, providing an operationally simple, low-cost, and environmentally benign synthetic technol. for mol. construction and elaboration.

Chemical Science published new progress about Green chemistry. 20582-55-2 belongs to class thiazole, and the molecular formula is C7H9NO2S, Formula: C7H9NO2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Miyamoto, Hidetoshi; Sakumoto, Chihiro; Takekoshi, Eriko; Maeda, Yukiko; Hiramoto, Narumi; Itoh, Takahiro; Kato, Yoshiaki published the artcile< Effective Method To Remove Metal Elements from Pharmaceutical Intermediates with Polychelated Resin Scavenger>, Recommanded Product: Ethyl 4-methylthiazole-5-carboxylate, the main research area is metal palladium catalyst removal pharmaceutical resin.

A catalytic reaction is an important methodol. for the production of pharmaceuticals from the viewpoint of green and sustainable chem. Since elemental impurity levels should be controlled within acceptable limits in API, the development of removal of element is also important as well. The technol. for removal of elements was developed using cost-effective polychelated resin scavenger. The precious elements were removed efficiently by passing through the packed cartridge filled with appropriate scavenger. The feasibility of the scavenger was evaluated, and the application for actual manufacturing process is described. In contrast to another type of immobilized scavengers, polychelated resin scavenger provides an inexpensive method to scavenge several elements.

Organic Process Research & Development published new progress about Activated charcoal Role: NUU (Other Use, Unclassified), USES (Uses). 20582-55-2 belongs to class thiazole, and the molecular formula is C7H9NO2S, Recommanded Product: Ethyl 4-methylthiazole-5-carboxylate.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Qin, Xurong; Feng, Boya; Dong, Jiaxing; Li, Xiaoyu; Xue, Ying; Lan, Jingbo; You, Jingsong published the artcile< Copper(II)-catalyzed dehydrogenative cross-coupling between two azoles>, Category: thiazole, the main research area is biazole preparation; azole dehydrogenative coupling copper catalyst.

The copper(II)-catalyzed dehydrogenative coupling between two different azoles for the preparation of unsym. biazoles e. g., I has been developed. The current catalytic system can effectively control the chemoselectivity for heterocoupling over homocoupling.

Journal of Organic Chemistry published new progress about Heterocyclic compounds, nitrogen-oxygen Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 20582-55-2 belongs to class thiazole, and the molecular formula is C7H9NO2S, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhou, Jiadi; Wang, Chaodong; Huang, Lei; Luo, Can; Ye, Shilu; Xu, Ning; Zhu, Yunsheng; Liu, Li; Ren, Quanlei; Chen, Zhi; Song, Shengjie; Li, Jianjun published the artcile< Self-photocatalyzed regulable alkylation of 2H-benzothiazoles with diverse aliphatic C-H donors>, Recommanded Product: Ethyl 4-methylthiazole-5-carboxylate, the main research area is benzothiazole alc photochem alkylation; alkyl hydroxy benzothiazole preparation; amide benzothiazole photochem alkylation; amido alkyl benzothiazole preparation; alc benzothiazole photochem alkylation; alkylbenzothiazole preparation.

Here, a mild and efficient method that combines self-photoredox catalysis and hydrogen atom transfer to achieve the alkylation of 2H-benzothiazoles with alcs., ethers, lactams, amides and alkane, which features broad substrate scope and excellent functional group compatibility was reported. Notably, alcs. can be used not only as hydroxyalkylating reagents, but also as dehydroxyalkylating reagents in this regulable alkylation protocol. The previous elusive self-photocatalytic mechanism was investigated and preliminary results on this catalytic alkylation were reported.

Green Chemistry published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 20582-55-2 belongs to class thiazole, and the molecular formula is C7H9NO2S, Recommanded Product: Ethyl 4-methylthiazole-5-carboxylate.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Doughty, Michael B.; Risinger, G. E. published the artcile< Studies on the aminopyrimidinyl group of thiamine>, HPLC of Formula: 20582-55-2, the main research area is aminopyrimidinyl group thiamine catalytic activity; catalyst thiamine benzoin condensation.

The thiazolium salt I, when refluxed with excess PhCHO in MeOH containing 2 equivalent Et3N yielded benzoin, as did the tricyclic form of thiamine II [R = (CH2)2OH], generated in basic EtOH from thiamine.HCl and NaOEt. In contrast, although the thiamine analog III underwent a rapid C-2 H/D exchange in acidic D2O, formation of its neutral tricyclic form II (R = CO2Et) (IV) in basic solution completely inhibited its ability to catalyze the benzoin condensation. These results are discussed in terms of the intramol. cyclization to form IV and the balance between the nucleophilicity of the aminopyrimidinyl group towards the C-2 position of the thiamine thiazolium ring, and the leaving group potential of the aminopyrimidinyl moiety.

Journal of the Chemical Society, Chemical Communications published new progress about Benzoin condensation reaction catalysts. 20582-55-2 belongs to class thiazole, and the molecular formula is C7H9NO2S, HPLC of Formula: 20582-55-2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica