Category: 20949-81-9

20949-81-9, 2-Phenylthiazole-4-carbaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

20949-81-9, COMPOUND 12.1. 38: 4-{6,7-DIMETHOXY-2-[(2-PHENYL-1,3-THIAZOL-5- YL) METHYLl-1, 2, 3, 4-TETRAHYDROISOOUINOLIN-1-YL- N- DIETHYLBENZAMIDE; INTERMEDIATE 5.1. 7 (50 mg, 0.14 mmol) and 2-phenyl-4-thiazolecarbaldehyde (51 mg, 0.27 mmol) were dissolved in 1,2-dichloroethane (2 mL) and sodium triacetoxyborohydride (115 mg, 0.54 mmol) was added. The reaction mixture was stirred at room temperature for 18 h. Resin-bound tosylhydrazine (0.27 g, 1.5 mmol/g) was added and the mixture was agitated for another 2 h. Dichloromethane and 2 M aqueous sodium hydroxide solution were added, the mixture was shaken and passed through a Whatman 1PS filter paper. The organic phase was evaporated to dryness and purified by flash chromatography to yield the product (74 mg, 0.136 mmol, quant.). 1H NMR (500 MHz, CDC13) : 1.09, 1.23 (2 brs, 6H), 2.80, 3.04, 3.28 (3 m, 6H), 3.52 (brs, 2H), 3.82, 3.90 (2 d, J 14 Hz, 2H), 3.61, 3.85 (2 s, 6H), 4.78 (s, 1H), 6.20, 6.63 (2 s, 2H), 7.35-7. 43 (m, 7H), 7.94 (d, J 7.5 Hz, 2H). (+) LRESIMS m/z 542 (100) [M+H] +.

The synthetic route of 20949-81-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; WO2005/61484; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20949-81-9,2-Phenylthiazole-4-carbaldehyde,as a common compound, the synthetic route is as follows.

A solution of aldehyde 5 (10 mmol), benzoylacetone 6(10 mmol), concentrated H2SO4 (0.1 mL), thiourea andmethanol (50 mL) was refluxed for 24 h. The mixture wascooled and the precipitates were collected and crystallizedfrom methanol to produce compound 7.Yield: 74%. mp:148-151C , 1HNMR (DMSO-d6) : 1.69(s,3H,CH3), 5.45 (s,1H,H4), 7.35 (s, 1H,H-thiazol), 7.45-7.82 (m, 10H, phenyl), 7.89 (bs,1H, NH), 9.20 (bs,1H, NH),13CNMR (DMSO-d6) : 16.3 (CH3-C6), 55.2 (C4-tetrahydropyrimidine), 110.3, 113.4, 127.1, 127.3, 128.1,128.2, 129.3, 129.5, 130.1, 130.3, 131.4, 133.4, 133.7, 137.8,155.2, 162.3, 170.1, 175.3, 188.4, IR (KBr) cm-1: 3317,3114, 2924, 1713, 1674, 1180. Anal. Calcd. for C21H17N3OS2: C, 64.42; H, 4.38; N, 10.73. Found: C, 64.39; H, 4.46;N,10.56.

20949-81-9, The synthetic route of 20949-81-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sharifzadeh, Mohammad; Khademi, Hamid Reza; Almasirad, Ali; Rezayan, Zahra; Ghayahbashi, Mohsen Rezayan; Amini, Mohsen; Letters in drug design and discovery; vol. 10; 9; (2013); p. 900 – 905;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica